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Gene: WDR49 |
Gene summary for WDR49 |
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Gene information | Species | Human | Gene symbol | WDR49 | Gene ID | 151790 |
Gene name | WD repeat domain 49 | |
Gene Alias | WDR49 | |
Cytomap | 3q26.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
151790 | WDR49 | LZE21D1 | Human | Esophagus | HGIN | 5.38e-03 | 5.71e-01 | 0.0632 |
151790 | WDR49 | LZE24T | Human | Esophagus | ESCC | 1.80e-03 | 1.50e-01 | 0.0596 |
151790 | WDR49 | LZE21T | Human | Esophagus | ESCC | 2.27e-11 | 6.03e-01 | 0.0655 |
151790 | WDR49 | P2T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.07e-01 | 0.1177 |
151790 | WDR49 | P8T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.59e-01 | 0.0889 |
151790 | WDR49 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.38e-01 | 0.1055 |
151790 | WDR49 | P48T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.33e-01 | 0.0959 |
151790 | WDR49 | P62T-E | Human | Esophagus | ESCC | 7.83e-12 | 2.59e-01 | 0.1302 |
151790 | WDR49 | P74T-E | Human | Esophagus | ESCC | 2.66e-02 | 1.19e-01 | 0.1479 |
151790 | WDR49 | P128T-E | Human | Esophagus | ESCC | 2.93e-10 | 3.01e-01 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR49 | SNV | Missense_Mutation | rs199677479 | c.1079G>A | p.Arg360His | p.R360H | Q8IV35 | protein_coding | tolerated(0.56) | benign(0) | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
WDR49 | SNV | Missense_Mutation | c.549N>G | p.Ile183Met | p.I183M | Q8IV35 | protein_coding | deleterious(0) | possibly_damaging(0.854) | TCGA-A8-A08P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
WDR49 | SNV | Missense_Mutation | novel | c.646G>C | p.Val216Leu | p.V216L | Q8IV35 | protein_coding | deleterious(0.01) | benign(0.217) | TCGA-AC-A4ZE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR49 | SNV | Missense_Mutation | c.620N>G | p.Leu207Arg | p.L207R | Q8IV35 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
WDR49 | SNV | Missense_Mutation | c.1736N>G | p.Asp579Gly | p.D579G | Q8IV35 | protein_coding | tolerated(0.34) | benign(0.026) | TCGA-C8-A12W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
WDR49 | SNV | Missense_Mutation | c.124N>C | p.Lys42Gln | p.K42Q | Q8IV35 | protein_coding | tolerated(0.25) | benign(0.034) | TCGA-E2-A14W-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
WDR49 | SNV | Missense_Mutation | c.1930N>A | p.Glu644Lys | p.E644K | Q8IV35 | protein_coding | tolerated(0.16) | benign(0.081) | TCGA-OL-A66L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WDR49 | deletion | Frame_Shift_Del | c.598delN | p.Asp201MetfsTer8 | p.D201Mfs*8 | Q8IV35 | protein_coding | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |||
WDR49 | deletion | Frame_Shift_Del | novel | c.679delN | p.His227IlefsTer3 | p.H227Ifs*3 | Q8IV35 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
WDR49 | SNV | Missense_Mutation | c.2041N>T | p.Ala681Ser | p.A681S | Q8IV35 | protein_coding | tolerated(0.28) | benign(0.115) | TCGA-C5-A0TN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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