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Gene: WDR47 |
Gene summary for WDR47 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | WDR47 | Gene ID | 22911 |
| Gene name | WD repeat domain 47 | |
| Gene Alias | WDR47 | |
| Cytomap | 1p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O94967 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 22911 | WDR47 | LZE4T | Human | Esophagus | ESCC | 8.12e-13 | 4.12e-01 | 0.0811 |
| 22911 | WDR47 | LZE24T | Human | Esophagus | ESCC | 9.16e-06 | 2.24e-01 | 0.0596 |
| 22911 | WDR47 | P1T-E | Human | Esophagus | ESCC | 1.20e-02 | 1.17e-01 | 0.0875 |
| 22911 | WDR47 | P2T-E | Human | Esophagus | ESCC | 5.91e-10 | 1.86e-01 | 0.1177 |
| 22911 | WDR47 | P4T-E | Human | Esophagus | ESCC | 4.90e-17 | 1.42e-01 | 0.1323 |
| 22911 | WDR47 | P5T-E | Human | Esophagus | ESCC | 1.01e-19 | 2.53e-01 | 0.1327 |
| 22911 | WDR47 | P8T-E | Human | Esophagus | ESCC | 4.28e-04 | 6.88e-02 | 0.0889 |
| 22911 | WDR47 | P9T-E | Human | Esophagus | ESCC | 3.68e-13 | 1.60e-01 | 0.1131 |
| 22911 | WDR47 | P10T-E | Human | Esophagus | ESCC | 9.86e-09 | 1.91e-01 | 0.116 |
| 22911 | WDR47 | P11T-E | Human | Esophagus | ESCC | 4.86e-10 | 3.92e-01 | 0.1426 |
| 22911 | WDR47 | P12T-E | Human | Esophagus | ESCC | 4.91e-20 | 4.89e-01 | 0.1122 |
| 22911 | WDR47 | P15T-E | Human | Esophagus | ESCC | 6.70e-11 | 7.14e-02 | 0.1149 |
| 22911 | WDR47 | P16T-E | Human | Esophagus | ESCC | 9.80e-11 | 4.72e-02 | 0.1153 |
| 22911 | WDR47 | P20T-E | Human | Esophagus | ESCC | 2.84e-08 | 2.21e-01 | 0.1124 |
| 22911 | WDR47 | P21T-E | Human | Esophagus | ESCC | 8.60e-03 | 7.22e-02 | 0.1617 |
| 22911 | WDR47 | P22T-E | Human | Esophagus | ESCC | 1.39e-07 | 1.86e-01 | 0.1236 |
| 22911 | WDR47 | P23T-E | Human | Esophagus | ESCC | 3.10e-15 | 2.76e-01 | 0.108 |
| 22911 | WDR47 | P24T-E | Human | Esophagus | ESCC | 8.03e-06 | 3.97e-02 | 0.1287 |
| 22911 | WDR47 | P26T-E | Human | Esophagus | ESCC | 2.76e-11 | 1.90e-01 | 0.1276 |
| 22911 | WDR47 | P27T-E | Human | Esophagus | ESCC | 1.17e-09 | 2.02e-01 | 0.1055 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| WDR47 | SNV | Missense_Mutation | rs752274935 | c.1646N>A | p.Ser549Asn | p.S549N | O94967 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD |
| WDR47 | SNV | Missense_Mutation | c.556N>T | p.Asp186Tyr | p.D186Y | O94967 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| WDR47 | SNV | Missense_Mutation | novel | c.2396T>C | p.Val799Ala | p.V799A | O94967 | protein_coding | deleterious(0) | possibly_damaging(0.608) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| WDR47 | SNV | Missense_Mutation | c.871N>G | p.Leu291Val | p.L291V | O94967 | protein_coding | tolerated(0.47) | probably_damaging(0.991) | TCGA-BH-A1FG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| WDR47 | SNV | Missense_Mutation | c.2216N>A | p.Gly739Glu | p.G739E | O94967 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A15P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
| WDR47 | insertion | Nonsense_Mutation | novel | c.2460_2461insAACAGGCTCTTATGATATGAAAATAAAG | p.Arg821AsnfsTer5 | p.R821Nfs*5 | O94967 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
| WDR47 | deletion | In_Frame_Del | c.739_744delTTGGAT | p.Asp248_Leu249del | p.D248_L249del | O94967 | protein_coding | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
| WDR47 | deletion | Frame_Shift_Del | novel | c.1495delG | p.Asp499MetfsTer27 | p.D499Mfs*27 | O94967 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| WDR47 | SNV | Missense_Mutation | novel | c.2342C>T | p.Ser781Phe | p.S781F | O94967 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| WDR47 | SNV | Missense_Mutation | novel | c.1976T>C | p.Val659Ala | p.V659A | O94967 | protein_coding | tolerated(0.69) | benign(0) | TCGA-GH-A9DA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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