|
Gene: WDR25 |
Gene summary for WDR25 |
Gene summary. |
Gene information | Species | Human | Gene symbol | WDR25 | Gene ID | 79446 |
Gene name | WD repeat domain 25 | |
Gene Alias | C14orf67 | |
Cytomap | 14q32.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q64LD2 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79446 | WDR25 | LZE24T | Human | Esophagus | ESCC | 6.28e-11 | 2.92e-01 | 0.0596 |
79446 | WDR25 | P2T-E | Human | Esophagus | ESCC | 3.21e-05 | 1.32e-01 | 0.1177 |
79446 | WDR25 | P4T-E | Human | Esophagus | ESCC | 7.93e-07 | 1.77e-01 | 0.1323 |
79446 | WDR25 | P5T-E | Human | Esophagus | ESCC | 7.90e-03 | 8.72e-02 | 0.1327 |
79446 | WDR25 | P8T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.53e-01 | 0.0889 |
79446 | WDR25 | P10T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.01e-01 | 0.116 |
79446 | WDR25 | P12T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.29e-01 | 0.1122 |
79446 | WDR25 | P15T-E | Human | Esophagus | ESCC | 5.83e-12 | 2.94e-01 | 0.1149 |
79446 | WDR25 | P16T-E | Human | Esophagus | ESCC | 7.47e-07 | 1.87e-01 | 0.1153 |
79446 | WDR25 | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 1.84e-01 | 0.1278 |
79446 | WDR25 | P20T-E | Human | Esophagus | ESCC | 3.11e-04 | 1.21e-01 | 0.1124 |
79446 | WDR25 | P21T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.37e-01 | 0.1617 |
79446 | WDR25 | P23T-E | Human | Esophagus | ESCC | 1.99e-08 | 2.01e-01 | 0.108 |
79446 | WDR25 | P24T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.63e-01 | 0.1287 |
79446 | WDR25 | P26T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.91e-01 | 0.1276 |
79446 | WDR25 | P27T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.64e-01 | 0.1055 |
79446 | WDR25 | P28T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.49e-01 | 0.1149 |
79446 | WDR25 | P30T-E | Human | Esophagus | ESCC | 1.89e-05 | 1.96e-01 | 0.137 |
79446 | WDR25 | P31T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.26e-01 | 0.1251 |
79446 | WDR25 | P32T-E | Human | Esophagus | ESCC | 2.03e-09 | 1.93e-01 | 0.1666 |
Page: 1 2 3 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR25 | SNV | Missense_Mutation | novel | c.685N>C | p.Tyr229His | p.Y229H | Q64LD2 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-AR-A2LL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
WDR25 | SNV | Missense_Mutation | c.214N>A | p.Asp72Asn | p.D72N | Q64LD2 | protein_coding | tolerated(0.16) | benign(0.058) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
WDR25 | SNV | Missense_Mutation | novel | c.1379G>A | p.Arg460Gln | p.R460Q | Q64LD2 | protein_coding | tolerated(0.06) | benign(0.01) | TCGA-LL-A441-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
WDR25 | insertion | Nonsense_Mutation | novel | c.158_159insAAGGTAGAGATGCATTCCAACAATCCCCAGGGCTGCTTCTGTGGTCT | p.Thr54ArgfsTer2 | p.T54Rfs*2 | Q64LD2 | protein_coding | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD | ||
WDR25 | SNV | Missense_Mutation | rs767532450 | c.100N>A | p.Gly34Ser | p.G34S | Q64LD2 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR25 | SNV | Missense_Mutation | novel | c.1310N>A | p.Arg437Lys | p.R437K | Q64LD2 | protein_coding | tolerated(0.69) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR25 | SNV | Missense_Mutation | novel | c.444N>A | p.Phe148Leu | p.F148L | Q64LD2 | protein_coding | tolerated(0.75) | benign(0) | TCGA-EK-A2RM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WDR25 | SNV | Missense_Mutation | novel | c.1230N>T | p.Trp410Cys | p.W410C | Q64LD2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MA-AA43-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
WDR25 | SNV | Missense_Mutation | rs529381627 | c.886N>T | p.Arg296Trp | p.R296W | Q64LD2 | protein_coding | deleterious(0) | benign(0.111) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR25 | SNV | Missense_Mutation | c.371N>T | p.Ala124Val | p.A124V | Q64LD2 | protein_coding | tolerated_low_confidence(0.13) | benign(0.003) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |