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Gene: WBSCR22 |
Gene summary for WBSCR22 |
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Gene information | Species | Human | Gene symbol | WBSCR22 | Gene ID | 114049 |
Gene name | BUD23 rRNA methyltransferase and ribosome maturation factor | |
Gene Alias | HASJ4442 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | O43709 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114049 | WBSCR22 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.02e-18 | 3.21e-01 | 0.294 |
114049 | WBSCR22 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.91e-08 | 8.07e-01 | 0.3487 |
114049 | WBSCR22 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.13e-20 | 4.93e-01 | 0.281 |
114049 | WBSCR22 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.12e-43 | 7.23e-01 | 0.3859 |
114049 | WBSCR22 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.62e-32 | 9.24e-01 | 0.2585 |
114049 | WBSCR22 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.12e-29 | 5.52e-01 | 0.3005 |
114049 | WBSCR22 | P1T-E | Human | Esophagus | ESCC | 4.83e-18 | 1.05e+00 | 0.0875 |
114049 | WBSCR22 | P2T-E | Human | Esophagus | ESCC | 1.02e-31 | 7.55e-01 | 0.1177 |
114049 | WBSCR22 | P4T-E | Human | Esophagus | ESCC | 3.15e-53 | 1.45e+00 | 0.1323 |
114049 | WBSCR22 | P5T-E | Human | Esophagus | ESCC | 8.95e-55 | 1.22e+00 | 0.1327 |
114049 | WBSCR22 | P8T-E | Human | Esophagus | ESCC | 1.94e-46 | 9.33e-01 | 0.0889 |
114049 | WBSCR22 | P9T-E | Human | Esophagus | ESCC | 1.30e-31 | 7.78e-01 | 0.1131 |
114049 | WBSCR22 | P10T-E | Human | Esophagus | ESCC | 6.74e-60 | 1.06e+00 | 0.116 |
114049 | WBSCR22 | P11T-E | Human | Esophagus | ESCC | 6.62e-20 | 1.02e+00 | 0.1426 |
114049 | WBSCR22 | P12T-E | Human | Esophagus | ESCC | 1.15e-74 | 1.45e+00 | 0.1122 |
114049 | WBSCR22 | P15T-E | Human | Esophagus | ESCC | 1.77e-70 | 1.61e+00 | 0.1149 |
114049 | WBSCR22 | P16T-E | Human | Esophagus | ESCC | 6.02e-87 | 1.97e+00 | 0.1153 |
114049 | WBSCR22 | P17T-E | Human | Esophagus | ESCC | 2.50e-09 | 6.87e-01 | 0.1278 |
114049 | WBSCR22 | P19T-E | Human | Esophagus | ESCC | 5.87e-12 | 9.55e-01 | 0.1662 |
114049 | WBSCR22 | P20T-E | Human | Esophagus | ESCC | 6.97e-37 | 7.84e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WBSCR22 | SNV | Missense_Mutation | c.349N>A | p.Asp117Asn | p.D117N | O43709 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WBSCR22 | SNV | Missense_Mutation | c.261N>C | p.Met87Ile | p.M87I | O43709 | protein_coding | deleterious(0) | possibly_damaging(0.861) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WBSCR22 | SNV | Missense_Mutation | novel | c.271N>T | p.Ala91Ser | p.A91S | O43709 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
WBSCR22 | SNV | Missense_Mutation | novel | c.265G>A | p.Asp89Asn | p.D89N | O43709 | protein_coding | tolerated(0.42) | benign(0.163) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
WBSCR22 | SNV | Missense_Mutation | c.626C>T | p.Ser209Leu | p.S209L | O43709 | protein_coding | tolerated(0.07) | benign(0.16) | TCGA-BH-A0HL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
WBSCR22 | insertion | Nonsense_Mutation | novel | c.874_875insTGGTCTAGCCCACCCCTAGTTTTCCTGG | p.Arg292LeufsTer3 | p.R292Lfs*3 | O43709 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
WBSCR22 | SNV | Missense_Mutation | novel | c.382C>T | p.Leu128Phe | p.L128F | O43709 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WBSCR22 | SNV | Missense_Mutation | novel | c.41N>A | p.Pro14Gln | p.P14Q | O43709 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
WBSCR22 | SNV | Missense_Mutation | c.533N>T | p.Ala178Val | p.A178V | O43709 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-DM-A28A-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
WBSCR22 | SNV | Missense_Mutation | novel | c.92G>A | p.Arg31Gln | p.R31Q | O43709 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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