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Gene: VWA3A |
Gene summary for VWA3A |
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Gene information | Species | Human | Gene symbol | VWA3A | Gene ID | 146177 |
Gene name | von Willebrand factor A domain containing 3A | |
Gene Alias | VWA3A | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A6NCI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146177 | VWA3A | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 5.87e-01 | -0.0238 |
146177 | VWA3A | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 5.54e-03 | 5.01e-01 | -0.0263 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VWA3A | SNV | Missense_Mutation | c.830C>T | p.Ser277Phe | p.S277F | A6NCI4 | protein_coding | tolerated(0.73) | benign(0.2) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
VWA3A | SNV | Missense_Mutation | c.241N>A | p.Glu81Lys | p.E81K | A6NCI4 | protein_coding | tolerated(0.69) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
VWA3A | SNV | Missense_Mutation | c.242N>T | p.Glu81Val | p.E81V | A6NCI4 | protein_coding | deleterious(0.03) | benign(0.235) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
VWA3A | SNV | Missense_Mutation | novel | c.3263C>A | p.Ser1088Tyr | p.S1088Y | A6NCI4 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VWA3A | SNV | Missense_Mutation | c.1451N>C | p.Arg484Thr | p.R484T | A6NCI4 | protein_coding | tolerated(0.07) | benign(0.05) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
VWA3A | SNV | Missense_Mutation | c.915N>T | p.Gln305His | p.Q305H | A6NCI4 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
VWA3A | SNV | Missense_Mutation | rs200655453 | c.2863N>A | p.Val955Ile | p.V955I | A6NCI4 | protein_coding | tolerated(1) | benign(0.003) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
VWA3A | SNV | Missense_Mutation | c.3035N>G | p.Leu1012Arg | p.L1012R | A6NCI4 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-E2-A14R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
VWA3A | SNV | Missense_Mutation | c.2458C>T | p.Leu820Phe | p.L820F | A6NCI4 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-E9-A228-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
VWA3A | SNV | Missense_Mutation | c.2107N>A | p.Glu703Lys | p.E703K | A6NCI4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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