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Gene: VNN3 |
Gene summary for VNN3 |
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Gene information | Species | Human | Gene symbol | VNN3 | Gene ID | 55350 |
Gene name | vanin 3, pseudogene | |
Gene Alias | HSA238982 | |
Cytomap | 6q23.2 | |
Gene Type | pseudo | GO ID | GO:0006082 | UniProtAcc | B2RBK8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55350 | VNN3 | C57 | Human | Oral cavity | OSCC | 5.53e-14 | 6.20e-01 | 0.1679 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00065756 | Oral cavity | OSCC | cellular modified amino acid metabolic process | 91/7305 | 188/18723 | 5.33e-03 | 2.07e-02 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VNN3 | SNV | Missense_Mutation | novel | c.652N>T | p.His218Tyr | p.H218Y | Q9NY84 | protein_coding | tolerated(0.34) | benign(0.007) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
VNN3 | SNV | Missense_Mutation | c.739N>T | p.Arg247Trp | p.R247W | Q9NY84 | protein_coding | deleterious_low_confidence(0.01) | benign(0.003) | TCGA-DM-A28C-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
VNN3 | insertion | Frame_Shift_Ins | novel | c.39dupT | p.Ala14CysfsTer19 | p.A14Cfs*19 | Q9NY84 | protein_coding | TCGA-CM-6167-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
VNN3 | SNV | Missense_Mutation | novel | c.650N>A | p.Ser217Tyr | p.S217Y | Q9NY84 | protein_coding | tolerated(0.13) | benign(0.063) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
VNN3 | SNV | Missense_Mutation | c.175N>T | p.Asp59Tyr | p.D59Y | Q9NY84 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
VNN3 | SNV | Missense_Mutation | novel | c.544N>A | p.Leu182Ile | p.L182I | Q9NY84 | protein_coding | deleterious(0.05) | possibly_damaging(0.594) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VNN3 | SNV | Missense_Mutation | c.175N>T | p.Asp59Tyr | p.D59Y | Q9NY84 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
VNN3 | SNV | Missense_Mutation | novel | c.385N>A | p.Ala129Thr | p.A129T | Q9NY84 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VNN3 | SNV | Missense_Mutation | rs113007523 | c.101N>T | p.Ala34Val | p.A34V | Q9NY84 | protein_coding | tolerated(0.07) | possibly_damaging(0.599) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
VNN3 | SNV | Missense_Mutation | novel | c.50C>T | p.Ala17Val | p.A17V | Q9NY84 | protein_coding | tolerated(0.88) | benign(0.005) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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