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Gene: VNN2 |
Gene summary for VNN2 |
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Gene information | Species | Human | Gene symbol | VNN2 | Gene ID | 8875 |
Gene name | vanin 2 | |
Gene Alias | FOAP-4 | |
Cytomap | 6q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | O95498 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8875 | VNN2 | LZE24T | Human | Esophagus | ESCC | 8.03e-05 | 7.51e-01 | 0.0596 |
8875 | VNN2 | P82T-E | Human | Esophagus | ESCC | 2.90e-08 | 1.11e+00 | 0.1072 |
8875 | VNN2 | P128T-E | Human | Esophagus | ESCC | 4.10e-02 | 3.35e-01 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:00067671 | Esophagus | ESCC | water-soluble vitamin metabolic process | 41/8552 | 59/18723 | 1.84e-04 | 1.17e-03 | 41 |
GO:00067661 | Esophagus | ESCC | vitamin metabolic process | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VNN2 | SNV | Missense_Mutation | novel | c.1521A>G | p.Ile507Met | p.I507M | O95498 | protein_coding | tolerated_low_confidence(0.14) | benign(0.135) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VNN2 | SNV | Missense_Mutation | c.385N>C | p.Ala129Pro | p.A129P | O95498 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
VNN2 | SNV | Missense_Mutation | c.1094N>A | p.Leu365His | p.L365H | O95498 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A0FZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
VNN2 | SNV | Missense_Mutation | c.165N>G | p.Asn55Lys | p.N55K | O95498 | protein_coding | tolerated(0.08) | possibly_damaging(0.775) | TCGA-AR-A1AH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | PD | ||
VNN2 | SNV | Missense_Mutation | novel | c.1025N>T | p.Ser342Phe | p.S342F | O95498 | protein_coding | tolerated(0.92) | benign(0) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VNN2 | SNV | Missense_Mutation | c.302C>T | p.Pro101Leu | p.P101L | O95498 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
VNN2 | SNV | Missense_Mutation | c.241G>A | p.Asp81Asn | p.D81N | O95498 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
VNN2 | insertion | Frame_Shift_Ins | novel | c.125_126insGTTGCTTCTTAGGCAGAAAGACTTCACCATGTATTTTCAAGTG | p.Thr43LeufsTer42 | p.T43Lfs*42 | O95498 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
VNN2 | deletion | Frame_Shift_Del | novel | c.67delC | p.Gln23ArgfsTer5 | p.Q23Rfs*5 | O95498 | protein_coding | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR | ||
VNN2 | insertion | In_Frame_Ins | novel | c.368_369insTGTTACCAACTTAGAGGGTTTTTATGAGTCATTTCTTCAACA | p.Ala123_Arg124insValThrAsnLeuGluGlyPheTyrGluSerPheLeuGlnGln | p.A123_R124insVTNLEGFYESFLQQ | O95498 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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