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Gene: VMO1 |
Gene summary for VMO1 |
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Gene information | Species | Human | Gene symbol | VMO1 | Gene ID | 284013 |
Gene name | vitelline membrane outer layer 1 homolog | |
Gene Alias | ERGA6350 | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q7Z5L0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284013 | VMO1 | LZE5T | Human | Esophagus | ESCC | 4.24e-14 | 1.50e+00 | 0.0514 |
284013 | VMO1 | P36T-E | Human | Esophagus | ESCC | 5.48e-08 | 6.05e-01 | 0.1187 |
284013 | VMO1 | P57T-E | Human | Esophagus | ESCC | 2.96e-08 | 5.78e-01 | 0.0926 |
284013 | VMO1 | P62T-E | Human | Esophagus | ESCC | 5.60e-04 | 1.14e-01 | 0.1302 |
284013 | VMO1 | P65T-E | Human | Esophagus | ESCC | 9.55e-23 | 9.47e-01 | 0.0978 |
284013 | VMO1 | P74T-E | Human | Esophagus | ESCC | 7.24e-03 | 2.04e-01 | 0.1479 |
284013 | VMO1 | P75T-E | Human | Esophagus | ESCC | 2.77e-10 | 5.63e-01 | 0.1125 |
284013 | VMO1 | P82T-E | Human | Esophagus | ESCC | 2.70e-02 | 3.30e-01 | 0.1072 |
284013 | VMO1 | P130T-E | Human | Esophagus | ESCC | 1.48e-12 | 7.06e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VMO1 | SNV | Missense_Mutation | c.295N>C | p.Glu99Gln | p.E99Q | Q7Z5L0 | protein_coding | tolerated(0.1) | benign(0.02) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
VMO1 | insertion | Frame_Shift_Ins | novel | c.522_523insCCGGCTGGTCTCGCCTGTTTAAG | p.Gly175ProfsTer26 | p.G175Pfs*26 | Q7Z5L0 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
VMO1 | insertion | Nonsense_Mutation | novel | c.151_152insGGCTGGGCTG | p.Glu51GlyfsTer4 | p.E51Gfs*4 | Q7Z5L0 | protein_coding | TCGA-C8-A12O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
VMO1 | SNV | Missense_Mutation | novel | c.344N>A | p.Arg115His | p.R115H | Q7Z5L0 | protein_coding | deleterious(0.04) | possibly_damaging(0.671) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
VMO1 | SNV | Missense_Mutation | novel | c.376C>T | p.Arg126Cys | p.R126C | Q7Z5L0 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
VMO1 | SNV | Missense_Mutation | c.226G>A | p.Asp76Asn | p.D76N | Q7Z5L0 | protein_coding | tolerated(0.08) | possibly_damaging(0.866) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
VMO1 | SNV | Missense_Mutation | novel | c.553G>T | p.Gly185Cys | p.G185C | Q7Z5L0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VMO1 | SNV | Missense_Mutation | novel | c.586C>T | p.Arg196Cys | p.R196C | Q7Z5L0 | protein_coding | deleterious(0) | possibly_damaging(0.865) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VMO1 | SNV | Missense_Mutation | rs749330135 | c.109N>A | p.Glu37Lys | p.E37K | Q7Z5L0 | protein_coding | tolerated(0.42) | benign(0.143) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VMO1 | SNV | Missense_Mutation | c.211N>T | p.Gly71Cys | p.G71C | Q7Z5L0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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