Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/VBP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/VBP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/VBP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/VBP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/VBP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000645720 | Esophagus | HGIN | protein folding | 75/2587 | 212/18723 | 1.61e-15 | 3.86e-13 | 75 |
GO:190290327 | Esophagus | HGIN | regulation of supramolecular fiber organization | 79/2587 | 383/18723 | 1.40e-04 | 2.81e-03 | 79 |
GO:199000010 | Esophagus | HGIN | amyloid fibril formation | 13/2587 | 34/18723 | 3.51e-04 | 5.65e-03 | 13 |
GO:19059068 | Esophagus | HGIN | regulation of amyloid fibril formation | 8/2587 | 16/18723 | 6.00e-04 | 8.41e-03 | 8 |
GO:19059078 | Esophagus | HGIN | negative regulation of amyloid fibril formation | 6/2587 | 13/18723 | 4.97e-03 | 4.18e-02 | 6 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:190590616 | Esophagus | ESCC | regulation of amyloid fibril formation | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:190590716 | Esophagus | ESCC | negative regulation of amyloid fibril formation | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:190290312 | Liver | Cirrhotic | regulation of supramolecular fiber organization | 148/4634 | 383/18723 | 8.85e-10 | 4.08e-08 | 148 |
GO:19900003 | Liver | Cirrhotic | amyloid fibril formation | 19/4634 | 34/18723 | 1.01e-04 | 1.05e-03 | 19 |
GO:1905907 | Liver | Cirrhotic | negative regulation of amyloid fibril formation | 10/4634 | 13/18723 | 1.14e-04 | 1.14e-03 | 10 |
GO:19029046 | Liver | Cirrhotic | negative regulation of supramolecular fiber organization | 63/4634 | 167/18723 | 1.29e-04 | 1.26e-03 | 63 |
GO:1905906 | Liver | Cirrhotic | regulation of amyloid fibril formation | 11/4634 | 16/18723 | 2.58e-04 | 2.30e-03 | 11 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:190290322 | Liver | HCC | regulation of supramolecular fiber organization | 224/7958 | 383/18723 | 1.54e-10 | 5.33e-09 | 224 |
GO:199000011 | Liver | HCC | amyloid fibril formation | 24/7958 | 34/18723 | 8.62e-04 | 5.13e-03 | 24 |
GO:190290412 | Liver | HCC | negative regulation of supramolecular fiber organization | 90/7958 | 167/18723 | 1.90e-03 | 9.69e-03 | 90 |
GO:19059071 | Liver | HCC | negative regulation of amyloid fibril formation | 11/7958 | 13/18723 | 2.38e-03 | 1.16e-02 | 11 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VBP1 | SNV | Missense_Mutation | | c.85G>A | p.Val29Met | p.V29M | P61758 | protein_coding | tolerated(0.17) | possibly_damaging(0.499) | TCGA-B6-A0RL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VBP1 | insertion | Nonsense_Mutation | novel | c.548_549insGTAAATATATTCTTTAACCAAGGGGTCAGCAAACTTTC | p.Asp183GlufsTer2 | p.D183Efs*2 | P61758 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
VBP1 | SNV | Missense_Mutation | novel | c.315N>A | p.Phe105Leu | p.F105L | P61758 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
VBP1 | SNV | Missense_Mutation | | c.120N>T | p.Gln40His | p.Q40H | P61758 | protein_coding | deleterious(0.02) | possibly_damaging(0.556) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
VBP1 | SNV | Missense_Mutation | novel | c.207A>C | p.Gln69His | p.Q69H | P61758 | protein_coding | deleterious(0.02) | possibly_damaging(0.905) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VBP1 | SNV | Missense_Mutation | | c.164N>G | p.Glu55Gly | p.E55G | P61758 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
VBP1 | SNV | Missense_Mutation | | c.438N>T | p.Lys146Asn | p.K146N | P61758 | protein_coding | tolerated(0.1) | benign(0.146) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
VBP1 | SNV | Missense_Mutation | novel | c.446C>T | p.Ser149Leu | p.S149L | P61758 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VBP1 | SNV | Missense_Mutation | novel | c.311N>T | p.Arg104Ile | p.R104I | P61758 | protein_coding | deleterious(0.02) | possibly_damaging(0.767) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
VBP1 | SNV | Missense_Mutation | | c.197N>G | p.Asn66Ser | p.N66S | P61758 | protein_coding | tolerated(0.1) | benign(0.106) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |