Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: UXT

Gene summary for UXT

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

UXT

Gene ID

8409

Gene nameubiquitously expressed prefoldin like chaperone
Gene AliasART-27
CytomapXp11.23
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

Q9UBK9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8409UXTGSM4909285HumanBreastIDC1.44e-04-2.18e-010.21
8409UXTGSM4909286HumanBreastIDC2.35e-02-3.69e-020.1081
8409UXTGSM4909287HumanBreastIDC7.17e-04-2.57e-010.2057
8409UXTGSM4909294HumanBreastIDC1.76e-04-6.03e-020.2022
8409UXTGSM4909296HumanBreastIDC5.31e-17-2.63e-010.1524
8409UXTGSM4909297HumanBreastIDC1.27e-22-3.38e-010.1517
8409UXTGSM4909302HumanBreastIDC1.04e-03-1.61e-010.1545
8409UXTGSM4909309HumanBreastIDC5.86e-03-1.05e-010.0483
8409UXTGSM4909311HumanBreastIDC8.84e-47-3.79e-010.1534
8409UXTGSM4909312HumanBreastIDC1.46e-19-2.83e-010.1552
8409UXTGSM4909313HumanBreastIDC2.43e-05-1.97e-010.0391
8409UXTGSM4909316HumanBreastIDC1.13e-03-1.13e-010.21
8409UXTGSM4909319HumanBreastIDC1.33e-50-5.53e-010.1563
8409UXTGSM4909320HumanBreastIDC2.42e-10-1.17e-010.1575
8409UXTGSM4909321HumanBreastIDC1.24e-18-1.27e-010.1559
8409UXTM2HumanBreastIDC1.75e-02-3.73e-010.21
8409UXTNCCBC14HumanBreastDCIS1.12e-16-3.72e-010.2021
8409UXTNCCBC2HumanBreastDCIS3.03e-06-3.73e-010.1554
8409UXTNCCBC3HumanBreastDCIS5.03e-03-7.40e-020.1198
8409UXTNCCBC5HumanBreastDCIS9.68e-23-9.30e-020.2046
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00516567CervixCCestablishment of organelle localization76/2311390/187233.17e-055.21e-0476
GO:00307057CervixCCcytoskeleton-dependent intracellular transport40/2311195/187237.92e-046.99e-0340
GO:00516541CervixCCestablishment of mitochondrion localization10/231129/187231.74e-031.31e-0210
GO:00516461CervixCCmitochondrion localization13/231150/187236.42e-033.58e-0213
GO:003070513CervixN_HPVcytoskeleton-dependent intracellular transport13/534195/187234.03e-033.16e-0213
GO:0051656ColorectumADestablishment of organelle localization131/3918390/187233.00e-092.06e-07131
GO:0030705ColorectumADcytoskeleton-dependent intracellular transport60/3918195/187237.56e-047.59e-0360
GO:0072384ColorectumADorganelle transport along microtubule28/391885/187236.55e-034.07e-0228
GO:00516561ColorectumSERestablishment of organelle localization100/2897390/187231.11e-076.79e-06100
GO:00307051ColorectumSERcytoskeleton-dependent intracellular transport44/2897195/187235.53e-034.09e-0244
GO:00516562ColorectumMSSestablishment of organelle localization115/3467390/187237.30e-083.67e-06115
GO:00307052ColorectumMSScytoskeleton-dependent intracellular transport52/3467195/187233.07e-032.34e-0252
GO:00516568EndometriumAEHestablishment of organelle localization77/2100390/187234.89e-071.94e-0577
GO:00307058EndometriumAEHcytoskeleton-dependent intracellular transport38/2100195/187234.72e-044.91e-0338
GO:005165613EndometriumEECestablishment of organelle localization75/2168390/187236.23e-061.49e-0475
GO:003070514EndometriumEECcytoskeleton-dependent intracellular transport39/2168195/187234.40e-044.58e-0339
GO:005165616EsophagusHGINestablishment of organelle localization90/2587390/187234.27e-071.94e-0590
GO:003070517EsophagusHGINcytoskeleton-dependent intracellular transport45/2587195/187233.07e-045.15e-0345
GO:00109707EsophagusHGINtransport along microtubule35/2587155/187232.01e-032.12e-0235
GO:00516542EsophagusHGINestablishment of mitochondrion localization10/258729/187234.07e-033.65e-0210
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
UXTSNVMissense_Mutationnovelc.187C>Ap.Gln63Lysp.Q63Kprotein_codingtolerated(0.1)probably_damaging(0.996)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
UXTSNVMissense_Mutationrs200352953c.41N>Tp.Ala14Valp.A14Vprotein_codingdeleterious_low_confidence(0.03)benign(0.015)TCGA-AA-A022-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
UXTSNVMissense_Mutationc.234G>Cp.Glu78Aspp.E78Dprotein_codingtolerated(0.23)benign(0.009)TCGA-F5-6861-01Colorectumrectum adenocarcinomaFemale<65I/IIUnknownUnknownSD
UXTSNVMissense_Mutationc.299N>Ap.Arg100Hisp.R100Hprotein_codingtolerated(0.14)benign(0.013)TCGA-A5-A7WJ-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
UXTSNVMissense_Mutationnovelc.370N>Tp.Arg124Cysp.R124Cprotein_codingdeleterious(0)possibly_damaging(0.857)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
UXTSNVMissense_Mutationrs372164152c.109N>Gp.Ser37Glyp.S37Gprotein_codingdeleterious(0.03)probably_damaging(0.94)TCGA-AJ-A3EL-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
UXTSNVMissense_Mutationc.299N>Ap.Arg100Hisp.R100Hprotein_codingtolerated(0.14)benign(0.013)TCGA-AX-A2HC-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapypaclitaxelPD
UXTSNVMissense_Mutationnovelc.152N>Ap.Arg51Glnp.R51Qprotein_codingtolerated(0.08)benign(0.283)TCGA-AX-A2HC-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapypaclitaxelPD
UXTSNVMissense_Mutationnovelc.377G>Ap.Ser126Asnp.S126Nprotein_codingtolerated(0.18)benign(0.079)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
UXTSNVMissense_Mutationnovelc.349N>Ap.Glu117Lysp.E117Kprotein_codingdeleterious(0)probably_damaging(0.999)TCGA-D1-A103-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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