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Gene: UTY |
Gene summary for UTY |
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Gene information | Species | Human | Gene symbol | UTY | Gene ID | 7404 |
Gene name | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | |
Gene Alias | KDM6AL | |
Cytomap | Yq11.221 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | F4MH35 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7404 | UTY | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.71e-15 | -5.21e-01 | 0.0155 |
7404 | UTY | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.71e-07 | -5.76e-01 | -0.1808 |
7404 | UTY | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.49e-02 | -7.33e-01 | 0.0216 |
7404 | UTY | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.19e-11 | -7.23e-01 | -0.0811 |
7404 | UTY | HTA11_347_2000001011 | Human | Colorectum | AD | 8.40e-29 | -7.55e-01 | -0.1954 |
7404 | UTY | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.82e-03 | -2.80e-01 | -0.1207 |
7404 | UTY | HTA11_696_2000001011 | Human | Colorectum | AD | 1.41e-06 | -2.17e-01 | -0.1464 |
7404 | UTY | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.99e-02 | -7.01e-01 | -0.1462 |
7404 | UTY | HTA11_546_2000001011 | Human | Colorectum | AD | 8.80e-05 | -2.57e-01 | -0.0842 |
7404 | UTY | HTA11_866_3004761011 | Human | Colorectum | AD | 5.62e-06 | -4.60e-01 | 0.096 |
7404 | UTY | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.76e-08 | -8.00e-01 | 0.0528 |
7404 | UTY | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.88e-17 | -7.89e-01 | 0.0338 |
7404 | UTY | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.12e-04 | -3.29e-01 | 0.0674 |
7404 | UTY | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.55e-12 | -3.76e-01 | 0.294 |
7404 | UTY | HTA11_99999965104_69814 | Human | Colorectum | MSS | 9.62e-11 | -7.25e-01 | 0.281 |
7404 | UTY | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.09e-11 | -7.84e-01 | 0.2585 |
7404 | UTY | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.04e-13 | -4.82e-01 | 0.3005 |
7404 | UTY | F007 | Human | Colorectum | FAP | 1.92e-21 | -8.00e-01 | 0.1176 |
7404 | UTY | A002-C-010 | Human | Colorectum | FAP | 2.49e-45 | -7.98e-01 | 0.242 |
7404 | UTY | A015-C-203 | Human | Colorectum | FAP | 3.14e-46 | -8.00e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:00165702 | Colorectum | CRC | histone modification | 75/2078 | 463/18723 | 4.95e-04 | 7.06e-03 | 75 |
GO:0006285 | Esophagus | HGIN | base-excision repair, AP site formation | 6/2587 | 12/18723 | 3.03e-03 | 2.88e-02 | 6 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:00062843 | Esophagus | ESCC | base-excision repair | 33/8552 | 43/18723 | 3.25e-05 | 2.69e-04 | 33 |
GO:00064824 | Esophagus | ESCC | protein demethylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00082144 | Esophagus | ESCC | protein dealkylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00165773 | Esophagus | ESCC | histone demethylation | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:00700763 | Esophagus | ESCC | histone lysine demethylation | 20/8552 | 28/18723 | 5.23e-03 | 1.97e-02 | 20 |
GO:0006304 | Esophagus | ESCC | DNA modification | 68/8552 | 120/18723 | 9.95e-03 | 3.42e-02 | 68 |
GO:00165703 | Liver | NAFLD | histone modification | 90/1882 | 463/18723 | 5.74e-10 | 1.28e-07 | 90 |
GO:0070076 | Liver | NAFLD | histone lysine demethylation | 10/1882 | 28/18723 | 2.46e-04 | 4.09e-03 | 10 |
GO:0016577 | Liver | NAFLD | histone demethylation | 10/1882 | 31/18723 | 6.28e-04 | 8.21e-03 | 10 |
GO:0006482 | Liver | NAFLD | protein demethylation | 10/1882 | 33/18723 | 1.09e-03 | 1.27e-02 | 10 |
GO:0008214 | Liver | NAFLD | protein dealkylation | 10/1882 | 33/18723 | 1.09e-03 | 1.27e-02 | 10 |
GO:0070988 | Liver | NAFLD | demethylation | 16/1882 | 73/18723 | 2.09e-03 | 2.06e-02 | 16 |
GO:001657011 | Liver | Cirrhotic | histone modification | 154/4634 | 463/18723 | 1.92e-05 | 2.57e-04 | 154 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:00165704 | Lung | IAC | histone modification | 93/2061 | 463/18723 | 5.41e-09 | 8.03e-07 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UTY | SNV | Missense_Mutation | c.1169G>T | p.Arg390Ile | p.R390I | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
UTY | SNV | Missense_Mutation | c.3344N>A | p.Ser1115Tyr | p.S1115Y | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
UTY | SNV | Missense_Mutation | novel | c.3446N>G | p.Lys1149Arg | p.K1149R | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UTY | SNV | Missense_Mutation | c.232N>A | p.Glu78Lys | p.E78K | protein_coding | deleterious(0.02) | probably_damaging(0.961) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
UTY | SNV | Missense_Mutation | novel | c.4246N>G | p.Phe1416Val | p.F1416V | protein_coding | tolerated(0.14) | probably_damaging(0.988) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
UTY | SNV | Missense_Mutation | novel | c.2365G>A | p.Asp789Asn | p.D789N | protein_coding | tolerated_low_confidence(0.48) | benign(0.07) | TCGA-DD-AAVZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
UTY | SNV | Missense_Mutation | c.1694N>C | p.Arg565Pro | p.R565P | protein_coding | tolerated(0.06) | probably_damaging(0.984) | TCGA-05-4403-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
UTY | SNV | Missense_Mutation | c.4137N>T | p.Glu1379Asp | p.E1379D | protein_coding | tolerated(0.16) | probably_damaging(0.99) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
UTY | deletion | Frame_Shift_Del | novel | c.4174delN | p.Ser1392AlafsTer8 | p.S1392Afs*8 | protein_coding | TCGA-55-8614-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
UTY | deletion | Frame_Shift_Del | novel | c.3083delN | p.Phe1028SerfsTer7 | p.F1028Sfs*7 | protein_coding | TCGA-66-2777-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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