Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: UTRN

Gene summary for UTRN

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

UTRN

Gene ID

7402

Gene nameutrophin
Gene AliasDMDL
Cytomap6q24.2
Gene Typeprotein-coding
GO ID

GO:0001952

UniProtAcc

P46939


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7402UTRNCCI_1HumanCervixCC4.78e-049.71e-010.528
7402UTRNCCI_3HumanCervixCC5.68e-087.88e-010.516
7402UTRNL1HumanCervixCC3.10e-03-2.46e-010.0802
7402UTRNHTA11_3410_2000001011HumanColorectumAD5.66e-43-7.90e-010.0155
7402UTRNHTA11_2487_2000001011HumanColorectumSER2.88e-18-7.76e-01-0.1808
7402UTRNHTA11_2951_2000001011HumanColorectumAD1.95e-13-1.21e+000.0216
7402UTRNHTA11_1938_2000001011HumanColorectumAD1.84e-10-5.27e-01-0.0811
7402UTRNHTA11_78_2000001011HumanColorectumAD2.50e-07-4.74e-01-0.1088
7402UTRNHTA11_2112_2000001011HumanColorectumSER1.37e-05-8.78e-01-0.2196
7402UTRNHTA11_3361_2000001011HumanColorectumAD1.98e-25-9.25e-01-0.1207
7402UTRNHTA11_83_2000001011HumanColorectumSER5.06e-06-4.58e-01-0.1526
7402UTRNHTA11_696_2000001011HumanColorectumAD3.21e-12-5.32e-01-0.1464
7402UTRNHTA11_866_2000001011HumanColorectumAD7.70e-07-5.10e-01-0.1001
7402UTRNHTA11_1391_2000001011HumanColorectumAD1.08e-08-4.78e-01-0.059
7402UTRNHTA11_2992_2000001011HumanColorectumSER1.16e-05-6.89e-01-0.1706
7402UTRNHTA11_5212_2000001011HumanColorectumAD1.04e-15-9.73e-01-0.2061
7402UTRNHTA11_5216_2000001011HumanColorectumSER1.38e-04-6.89e-01-0.1462
7402UTRNHTA11_546_2000001011HumanColorectumAD2.03e-04-4.64e-01-0.0842
7402UTRNHTA11_9341_2000001011HumanColorectumSER2.47e-04-8.02e-01-0.00410000000000005
7402UTRNHTA11_866_3004761011HumanColorectumAD3.30e-19-6.34e-010.096
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001081010CervixCCregulation of cell-substrate adhesion69/2311221/187238.57e-145.69e-1169
GO:00315898CervixCCcell-substrate adhesion96/2311363/187231.48e-138.85e-1196
GO:004578510CervixCCpositive regulation of cell adhesion101/2311437/187231.96e-103.08e-08101
GO:00019528CervixCCregulation of cell-matrix adhesion40/2311128/187231.32e-081.04e-0640
GO:00071608CervixCCcell-matrix adhesion60/2311233/187231.58e-081.23e-0660
GO:001081110CervixCCpositive regulation of cell-substrate adhesion34/2311123/187233.66e-069.68e-0534
GO:19023059CervixCCregulation of sodium ion transmembrane transport19/231168/187234.21e-044.25e-0319
GO:00020288CervixCCregulation of sodium ion transport21/231190/187232.71e-031.85e-0221
GO:00075173CervixCCmuscle organ development58/2311327/187232.73e-031.85e-0258
GO:00019548CervixCCpositive regulation of cell-matrix adhesion15/231158/187233.75e-032.38e-0215
GO:20006498CervixCCregulation of sodium ion transmembrane transporter activity15/231158/187233.75e-032.38e-0215
GO:0010811ColorectumADpositive regulation of cell-substrate adhesion53/3918123/187232.30e-081.27e-0653
GO:0010810ColorectumADregulation of cell-substrate adhesion81/3918221/187234.80e-082.55e-0681
GO:0031589ColorectumADcell-substrate adhesion116/3918363/187234.68e-071.76e-05116
GO:0001952ColorectumADregulation of cell-matrix adhesion50/3918128/187232.05e-066.05e-0550
GO:0001954ColorectumADpositive regulation of cell-matrix adhesion27/391858/187231.12e-052.55e-0427
GO:0002028ColorectumADregulation of sodium ion transport36/391890/187232.89e-055.37e-0436
GO:0007160ColorectumADcell-matrix adhesion75/3918233/187233.56e-056.45e-0475
GO:0045785ColorectumADpositive regulation of cell adhesion122/3918437/187232.65e-043.28e-03122
GO:1902305ColorectumADregulation of sodium ion transmembrane transport27/391868/187233.19e-043.80e-0327
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
UTRNSNVMissense_Mutationnovelc.8216G>Cp.Arg2739Thrp.R2739TP46939protein_codingdeleterious(0)benign(0.153)TCGA-3C-AALI-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPoly EComplete Response
UTRNSNVMissense_Mutationc.4951N>Gp.Gln1651Glup.Q1651EP46939protein_codingdeleterious(0.01)probably_damaging(0.965)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
UTRNSNVMissense_Mutationnovelc.2422G>Cp.Asp808Hisp.D808HP46939protein_codingtolerated(0.06)benign(0.352)TCGA-A2-A0YK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
UTRNSNVMissense_Mutationc.8662G>Ap.Glu2888Lysp.E2888KP46939protein_codingdeleterious(0.02)benign(0.087)TCGA-A2-A0YK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
UTRNSNVMissense_Mutationc.2248N>Gp.Gln750Glup.Q750EP46939protein_codingtolerated(0.09)benign(0.034)TCGA-A8-A07U-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapy5-fluorouracilSD
UTRNSNVMissense_Mutationc.5062N>Cp.Glu1688Glnp.E1688QP46939protein_codingdeleterious(0.04)benign(0.246)TCGA-A8-A094-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
UTRNSNVMissense_Mutationc.9578G>Cp.Arg3193Thrp.R3193TP46939protein_codingdeleterious(0)probably_damaging(0.955)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
UTRNSNVMissense_Mutationc.2587N>Cp.Ser863Prop.S863PP46939protein_codingtolerated(0.26)benign(0.037)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
UTRNSNVMissense_Mutationnovelc.8603N>Cp.Lys2868Thrp.K2868TP46939protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AO-A0J3-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycyclophosphamideSD
UTRNSNVMissense_Mutationc.9787N>Gp.Leu3263Valp.L3263VP46939protein_codingdeleterious(0)probably_damaging(0.977)TCGA-AR-A251-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
7402UTRNNAENZYME INHIBITOR15639474
7402UTRNNASMT-C1100EZUTROMID
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