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Gene: UPK3B |
Gene summary for UPK3B |
Gene summary. |
Gene information | Species | Human | Gene symbol | UPK3B | Gene ID | 105375355 |
Gene name | uroplakin 3B | |
Gene Alias | P35 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9BT76 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
105375355 | UPK3B | LZE20T | Human | Esophagus | ESCC | 1.97e-04 | 2.07e-01 | 0.0662 |
105375355 | UPK3B | P4T-E | Human | Esophagus | ESCC | 1.22e-08 | 2.21e-01 | 0.1323 |
105375355 | UPK3B | P8T-E | Human | Esophagus | ESCC | 8.96e-45 | 1.15e+00 | 0.0889 |
105375355 | UPK3B | P9T-E | Human | Esophagus | ESCC | 1.11e-03 | 2.01e-01 | 0.1131 |
105375355 | UPK3B | P10T-E | Human | Esophagus | ESCC | 3.52e-19 | 4.56e-01 | 0.116 |
105375355 | UPK3B | P24T-E | Human | Esophagus | ESCC | 3.97e-04 | 2.03e-01 | 0.1287 |
105375355 | UPK3B | P30T-E | Human | Esophagus | ESCC | 2.13e-03 | 1.74e-01 | 0.137 |
105375355 | UPK3B | P31T-E | Human | Esophagus | ESCC | 9.86e-34 | 8.09e-01 | 0.1251 |
105375355 | UPK3B | P52T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.44e-01 | 0.1555 |
105375355 | UPK3B | P62T-E | Human | Esophagus | ESCC | 1.19e-05 | 1.94e-01 | 0.1302 |
105375355 | UPK3B | P65T-E | Human | Esophagus | ESCC | 7.92e-09 | 3.25e-01 | 0.0978 |
105375355 | UPK3B | P74T-E | Human | Esophagus | ESCC | 8.34e-46 | 2.22e+00 | 0.1479 |
105375355 | UPK3B | P75T-E | Human | Esophagus | ESCC | 1.06e-41 | 9.68e-01 | 0.1125 |
105375355 | UPK3B | P80T-E | Human | Esophagus | ESCC | 4.98e-02 | 1.18e-01 | 0.155 |
105375355 | UPK3B | P82T-E | Human | Esophagus | ESCC | 1.11e-22 | 1.54e+00 | 0.1072 |
105375355 | UPK3B | P83T-E | Human | Esophagus | ESCC | 1.35e-05 | 1.94e-01 | 0.1738 |
105375355 | UPK3B | P128T-E | Human | Esophagus | ESCC | 1.29e-09 | 3.41e-01 | 0.1241 |
105375355 | UPK3B | P130T-E | Human | Esophagus | ESCC | 2.06e-59 | 1.75e+00 | 0.1676 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UPK3B | SNV | Missense_Mutation | rs758702310 | c.647N>A | p.Arg216Gln | p.R216Q | Q9BT76 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.922) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UPK3B | SNV | Missense_Mutation | rs376925113 | c.952N>T | p.Arg318Cys | p.R318C | Q9BT76 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
UPK3B | SNV | Missense_Mutation | novel | c.511T>C | p.Cys171Arg | p.C171R | Q9BT76 | protein_coding | tolerated_low_confidence(0.11) | probably_damaging(0.998) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UPK3B | SNV | Missense_Mutation | rs767698299 | c.797C>T | p.Ala266Val | p.A266V | Q9BT76 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.454) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
UPK3B | SNV | Missense_Mutation | novel | c.626N>A | p.Arg209Gln | p.R209Q | Q9BT76 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.986) | TCGA-BS-A0VI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UPK3B | SNV | Missense_Mutation | novel | c.107A>G | p.Asp36Gly | p.D36G | Q9BT76 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
UPK3B | SNV | Missense_Mutation | rs185545742 | c.662C>T | p.Ala221Val | p.A221V | Q9BT76 | protein_coding | deleterious_low_confidence(0.04) | benign(0.287) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
UPK3B | SNV | Missense_Mutation | novel | c.721N>C | p.Thr241Pro | p.T241P | Q9BT76 | protein_coding | deleterious_low_confidence(0.03) | benign(0.018) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UPK3B | SNV | Missense_Mutation | c.446N>T | p.Ala149Val | p.A149V | Q9BT76 | protein_coding | tolerated_low_confidence(0.19) | benign(0.295) | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
UPK3B | insertion | Frame_Shift_Ins | rs764199566 | c.175dupC | p.Leu59ProfsTer88 | p.L59Pfs*88 | Q9BT76 | protein_coding | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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