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Gene: UPK3A |
Gene summary for UPK3A |
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Gene information | Species | Human | Gene symbol | UPK3A | Gene ID | 7380 |
Gene name | uroplakin 3A | |
Gene Alias | UP3A | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75631 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7380 | UPK3A | HCC1_Meng | Human | Liver | HCC | 2.09e-11 | 5.09e-02 | 0.0246 |
7380 | UPK3A | HCC1 | Human | Liver | HCC | 2.79e-12 | 3.52e+00 | 0.5336 |
7380 | UPK3A | HCC2 | Human | Liver | HCC | 1.49e-03 | 1.77e+00 | 0.5341 |
7380 | UPK3A | S014 | Human | Liver | HCC | 2.32e-07 | 2.78e-01 | 0.2254 |
7380 | UPK3A | S029 | Human | Liver | HCC | 2.82e-03 | 1.11e-01 | 0.2581 |
7380 | UPK3A | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 1.07e-03 | 3.20e-01 | -0.1771 |
7380 | UPK3A | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 1.28e-07 | 3.96e-01 | -0.2126 |
7380 | UPK3A | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 3.54e-08 | 4.56e-01 | -0.1833 |
7380 | UPK3A | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 9.40e-03 | 3.04e-01 | -0.23 |
7380 | UPK3A | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 3.49e-11 | 5.62e-01 | -0.23 |
7380 | UPK3A | Dong_P1 | Human | Prostate | Tumor | 2.44e-06 | 4.35e-02 | 0.035 |
7380 | UPK3A | Dong_P3 | Human | Prostate | Tumor | 4.16e-36 | 7.30e-01 | 0.0278 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016553 | Liver | HCC | urogenital system development | 170/7958 | 338/18723 | 2.15e-03 | 1.08e-02 | 170 |
GO:00018222 | Liver | HCC | kidney development | 148/7958 | 293/18723 | 3.25e-03 | 1.49e-02 | 148 |
GO:00720012 | Liver | HCC | renal system development | 152/7958 | 302/18723 | 3.45e-03 | 1.56e-02 | 152 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052192 | Liver | HCC | Bladder cancer | 30/4020 | 41/8465 | 7.37e-04 | 2.94e-03 | 1.63e-03 | 30 |
hsa052193 | Liver | HCC | Bladder cancer | 30/4020 | 41/8465 | 7.37e-04 | 2.94e-03 | 1.63e-03 | 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UPK3A | SNV | Missense_Mutation | c.721N>C | p.Asp241His | p.D241H | O75631 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
UPK3A | SNV | Missense_Mutation | rs758703602 | c.691N>A | p.Ala231Thr | p.A231T | O75631 | protein_coding | tolerated(0.26) | benign(0.036) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UPK3A | SNV | Missense_Mutation | rs188696049 | c.341N>T | p.Pro114Leu | p.P114L | O75631 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UPK3A | SNV | Missense_Mutation | rs201416292 | c.571N>T | p.Leu191Phe | p.L191F | O75631 | protein_coding | tolerated(0.71) | benign(0.123) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UPK3A | SNV | Missense_Mutation | rs757898653 | c.329N>A | p.Cys110Tyr | p.C110Y | O75631 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UPK3A | SNV | Missense_Mutation | novel | c.325N>T | p.Pro109Ser | p.P109S | O75631 | protein_coding | tolerated(0.23) | benign(0.163) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UPK3A | SNV | Missense_Mutation | novel | c.136N>A | p.Leu46Ile | p.L46I | O75631 | protein_coding | tolerated(0.13) | benign(0.066) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UPK3A | SNV | Missense_Mutation | c.66N>T | p.Gln22His | p.Q22H | O75631 | protein_coding | deleterious(0.01) | possibly_damaging(0.66) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UPK3A | SNV | Missense_Mutation | rs761759676 | c.773N>T | p.Ser258Leu | p.S258L | O75631 | protein_coding | deleterious(0.01) | benign(0.187) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UPK3A | SNV | Missense_Mutation | novel | c.644N>C | p.Leu215Pro | p.L215P | O75631 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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