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Gene: UPK1B |
Gene summary for UPK1B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | UPK1B | Gene ID | 7348 |
| Gene name | uroplakin 1B | |
| Gene Alias | TSPAN20 | |
| Cytomap | 3q13.32 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | O75841 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7348 | UPK1B | AEH-subject1 | Human | Endometrium | AEH | 1.61e-05 | 2.19e-01 | -0.3059 |
| 7348 | UPK1B | AEH-subject3 | Human | Endometrium | AEH | 3.68e-05 | 2.65e-01 | -0.2576 |
| 7348 | UPK1B | AEH-subject4 | Human | Endometrium | AEH | 3.99e-13 | 3.91e-01 | -0.2657 |
| 7348 | UPK1B | AEH-subject5 | Human | Endometrium | AEH | 7.54e-56 | 9.60e-01 | -0.2953 |
| 7348 | UPK1B | EEC-subject2 | Human | Endometrium | EEC | 4.05e-08 | 2.68e-01 | -0.2607 |
| 7348 | UPK1B | EEC-subject4 | Human | Endometrium | EEC | 6.00e-28 | 6.23e-01 | -0.2571 |
| 7348 | UPK1B | GSM5276937 | Human | Endometrium | EEC | 2.49e-02 | 1.74e-01 | -0.0897 |
| 7348 | UPK1B | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 9.62e-32 | 9.64e-01 | -0.1934 |
| 7348 | UPK1B | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.30e-05 | 3.00e-01 | -0.1916 |
| 7348 | UPK1B | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.17e-16 | 4.55e-01 | -0.1269 |
| 7348 | UPK1B | LZE11D | Human | Esophagus | HGIN | 2.05e-03 | 3.51e-01 | -0.005 |
| 7348 | UPK1B | LZE4T | Human | Esophagus | ESCC | 2.41e-27 | 1.56e+00 | 0.0811 |
| 7348 | UPK1B | LZE5T | Human | Esophagus | ESCC | 1.54e-04 | 1.05e+00 | 0.0514 |
| 7348 | UPK1B | LZE20T | Human | Esophagus | ESCC | 4.10e-17 | 1.07e+00 | 0.0662 |
| 7348 | UPK1B | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 4.13e-01 | 0.068 |
| 7348 | UPK1B | LZE24D1 | Human | Esophagus | HGIN | 3.66e-03 | 2.23e+00 | 0.054 |
| 7348 | UPK1B | LZE24T | Human | Esophagus | ESCC | 2.88e-80 | 4.15e+00 | 0.0596 |
| 7348 | UPK1B | LZE21T | Human | Esophagus | ESCC | 2.11e-16 | 1.99e+00 | 0.0655 |
| 7348 | UPK1B | P1T-E | Human | Esophagus | ESCC | 2.97e-02 | 2.20e-01 | 0.0875 |
| 7348 | UPK1B | P12T-E | Human | Esophagus | ESCC | 2.86e-20 | 1.42e+00 | 0.1122 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| UPK1B | SNV | Missense_Mutation | rs368350153 | c.92C>T | p.Ala31Val | p.A31V | O75841 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| UPK1B | SNV | Missense_Mutation | rs763183222 | c.76N>A | p.Gly26Ser | p.G26S | O75841 | protein_coding | deleterious(0.02) | benign(0.04) | TCGA-AA-3975-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| UPK1B | SNV | Missense_Mutation | c.742C>T | p.Leu248Phe | p.L248F | O75841 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| UPK1B | SNV | Missense_Mutation | rs761099050 | c.157N>A | p.Asp53Asn | p.D53N | O75841 | protein_coding | tolerated(0.13) | benign(0.11) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| UPK1B | SNV | Missense_Mutation | rs761099050 | c.157N>A | p.Asp53Asn | p.D53N | O75841 | protein_coding | tolerated(0.13) | benign(0.11) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| UPK1B | SNV | Missense_Mutation | rs769296250 | c.25N>T | p.Arg9Cys | p.R9C | O75841 | protein_coding | deleterious(0.02) | possibly_damaging(0.894) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| UPK1B | SNV | Missense_Mutation | novel | c.398N>A | p.Ser133Asn | p.S133N | O75841 | protein_coding | tolerated(0.38) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| UPK1B | SNV | Missense_Mutation | rs368350153 | c.92N>T | p.Ala31Val | p.A31V | O75841 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| UPK1B | SNV | Missense_Mutation | novel | c.694N>T | p.Gly232Trp | p.G232W | O75841 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| UPK1B | SNV | Missense_Mutation | c.23T>C | p.Val8Ala | p.V8A | O75841 | protein_coding | tolerated(0.11) | benign(0.015) | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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