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Gene: UNG |
Gene summary for UNG |
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Gene information | Species | Human | Gene symbol | UNG | Gene ID | 7374 |
Gene name | uracil DNA glycosylase | |
Gene Alias | DGU | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | E5KTA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7374 | UNG | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.27e-05 | 2.36e-01 | 0.0674 |
7374 | UNG | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.35e-09 | 3.39e-01 | 0.294 |
7374 | UNG | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.69e-03 | 2.27e-01 | 0.3859 |
7374 | UNG | LZE2T | Human | Esophagus | ESCC | 5.25e-04 | 4.16e-01 | 0.082 |
7374 | UNG | LZE4T | Human | Esophagus | ESCC | 2.28e-07 | 2.99e-01 | 0.0811 |
7374 | UNG | LZE7T | Human | Esophagus | ESCC | 7.83e-07 | 7.24e-01 | 0.0667 |
7374 | UNG | LZE20T | Human | Esophagus | ESCC | 4.92e-03 | 4.34e-02 | 0.0662 |
7374 | UNG | LZE24T | Human | Esophagus | ESCC | 3.36e-09 | 3.22e-01 | 0.0596 |
7374 | UNG | LZE6T | Human | Esophagus | ESCC | 3.73e-02 | 3.53e-01 | 0.0845 |
7374 | UNG | P1T-E | Human | Esophagus | ESCC | 1.67e-03 | 3.96e-01 | 0.0875 |
7374 | UNG | P2T-E | Human | Esophagus | ESCC | 2.20e-52 | 1.37e+00 | 0.1177 |
7374 | UNG | P4T-E | Human | Esophagus | ESCC | 6.96e-25 | 7.55e-01 | 0.1323 |
7374 | UNG | P5T-E | Human | Esophagus | ESCC | 2.87e-14 | 4.66e-01 | 0.1327 |
7374 | UNG | P8T-E | Human | Esophagus | ESCC | 1.18e-21 | 6.02e-01 | 0.0889 |
7374 | UNG | P9T-E | Human | Esophagus | ESCC | 5.41e-07 | 1.29e-01 | 0.1131 |
7374 | UNG | P10T-E | Human | Esophagus | ESCC | 4.10e-16 | 4.85e-01 | 0.116 |
7374 | UNG | P11T-E | Human | Esophagus | ESCC | 1.24e-13 | 7.09e-01 | 0.1426 |
7374 | UNG | P12T-E | Human | Esophagus | ESCC | 2.63e-16 | 3.42e-01 | 0.1122 |
7374 | UNG | P15T-E | Human | Esophagus | ESCC | 1.60e-15 | 5.14e-01 | 0.1149 |
7374 | UNG | P16T-E | Human | Esophagus | ESCC | 9.14e-27 | 6.76e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:00442702 | Colorectum | MSS | cellular nitrogen compound catabolic process | 141/3467 | 451/18723 | 2.95e-11 | 3.83e-09 | 141 |
GO:00467002 | Colorectum | MSS | heterocycle catabolic process | 139/3467 | 445/18723 | 4.37e-11 | 5.05e-09 | 139 |
GO:00346552 | Colorectum | MSS | nucleobase-containing compound catabolic process | 129/3467 | 407/18723 | 7.48e-11 | 8.18e-09 | 129 |
GO:19013612 | Colorectum | MSS | organic cyclic compound catabolic process | 148/3467 | 495/18723 | 3.47e-10 | 3.18e-08 | 148 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:00091172 | Colorectum | MSS | nucleotide metabolic process | 144/3467 | 489/18723 | 1.87e-09 | 1.35e-07 | 144 |
GO:00067532 | Colorectum | MSS | nucleoside phosphate metabolic process | 145/3467 | 497/18723 | 3.25e-09 | 2.23e-07 | 145 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa034104 | Esophagus | ESCC | Base excision repair | 38/4205 | 44/8465 | 3.59e-07 | 2.62e-06 | 1.34e-06 | 38 |
hsa0341011 | Esophagus | ESCC | Base excision repair | 38/4205 | 44/8465 | 3.59e-07 | 2.62e-06 | 1.34e-06 | 38 |
hsa03410 | Oral cavity | OSCC | Base excision repair | 32/3704 | 44/8465 | 9.11e-05 | 3.25e-04 | 1.65e-04 | 32 |
hsa034101 | Oral cavity | OSCC | Base excision repair | 32/3704 | 44/8465 | 9.11e-05 | 3.25e-04 | 1.65e-04 | 32 |
hsa034102 | Oral cavity | LP | Base excision repair | 23/2418 | 44/8465 | 7.66e-04 | 3.75e-03 | 2.42e-03 | 23 |
hsa034103 | Oral cavity | LP | Base excision repair | 23/2418 | 44/8465 | 7.66e-04 | 3.75e-03 | 2.42e-03 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UNG | insertion | Frame_Shift_Ins | novel | c.531_532insCTTGATCTCAGGAATTTGAGACCAGCCTCAGCAACATA | p.Ser178LeufsTer13 | p.S178Lfs*13 | P13051 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
UNG | SNV | Missense_Mutation | c.487N>T | p.His163Tyr | p.H163Y | P13051 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
UNG | SNV | Missense_Mutation | c.296N>T | p.Lys99Met | p.K99M | P13051 | protein_coding | tolerated(0.23) | benign(0.044) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
UNG | SNV | Missense_Mutation | c.640N>A | p.Ala214Thr | p.A214T | P13051 | protein_coding | tolerated(0.51) | benign(0.228) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UNG | SNV | Missense_Mutation | rs143034537 | c.805N>T | p.Arg269Trp | p.R269W | P13051 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UNG | insertion | Frame_Shift_Ins | novel | c.309_310insG | p.Glu105GlyfsTer38 | p.E105Gfs*38 | P13051 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
UNG | insertion | Nonsense_Mutation | novel | c.685_686insTAAATCCAT | p.Arg229delinsLeuAsnProTer | p.R229delinsLNP* | P13051 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
UNG | SNV | Missense_Mutation | rs143034537 | c.805N>T | p.Arg269Trp | p.R269W | P13051 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNG | SNV | Missense_Mutation | novel | c.38C>A | p.Pro13His | p.P13H | P13051 | protein_coding | deleterious(0) | possibly_damaging(0.557) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UNG | SNV | Missense_Mutation | novel | c.346N>A | p.Gly116Arg | p.G116R | P13051 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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