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Gene: UNC5D |
Gene summary for UNC5D |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | UNC5D | Gene ID | 137970 |
| Gene name | unc-5 netrin receptor D | |
| Gene Alias | PRO34692 | |
| Cytomap | 8p12 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q6UXZ4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 137970 | UNC5D | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.13e-07 | 1.15e-01 | 0.0155 |
| 137970 | UNC5D | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.44e-11 | 3.03e-01 | -0.1808 |
| 137970 | UNC5D | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.24e-16 | 4.41e-01 | -0.0811 |
| 137970 | UNC5D | HTA11_78_2000001011 | Human | Colorectum | AD | 9.35e-12 | 3.88e-01 | -0.1088 |
| 137970 | UNC5D | HTA11_347_2000001011 | Human | Colorectum | AD | 2.85e-18 | 3.19e-01 | -0.1954 |
| 137970 | UNC5D | HTA11_411_2000001011 | Human | Colorectum | SER | 1.15e-07 | 4.09e-01 | -0.2602 |
| 137970 | UNC5D | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.97e-02 | 2.78e-01 | -0.2196 |
| 137970 | UNC5D | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.52e-06 | 2.49e-01 | -0.1207 |
| 137970 | UNC5D | HTA11_696_2000001011 | Human | Colorectum | AD | 2.92e-11 | 2.65e-01 | -0.1464 |
| 137970 | UNC5D | HTA11_866_2000001011 | Human | Colorectum | AD | 2.61e-06 | 2.15e-01 | -0.1001 |
| 137970 | UNC5D | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.47e-20 | 4.65e-01 | -0.059 |
| 137970 | UNC5D | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.47e-07 | 3.04e-01 | -0.1706 |
| 137970 | UNC5D | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.40e-04 | 2.72e-01 | -0.2061 |
| 137970 | UNC5D | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.29e-03 | 2.79e-01 | -0.1462 |
| 137970 | UNC5D | HTA11_546_2000001011 | Human | Colorectum | AD | 4.21e-10 | 2.60e-01 | -0.0842 |
| 137970 | UNC5D | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.55e-02 | 1.87e-01 | -0.0179 |
| 137970 | UNC5D | HTA11_866_3004761011 | Human | Colorectum | AD | 4.30e-16 | 2.37e-01 | 0.096 |
| 137970 | UNC5D | HTA11_4255_2000001011 | Human | Colorectum | SER | 8.50e-04 | 3.34e-01 | 0.0446 |
| 137970 | UNC5D | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.38e-05 | 2.58e-01 | 0.0528 |
| 137970 | UNC5D | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.13e-06 | 4.56e-01 | -0.0177 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
| GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
| GO:0021859 | Colorectum | AD | pyramidal neuron differentiation | 9/3918 | 13/18723 | 2.38e-04 | 3.03e-03 | 9 |
| GO:0007411 | Colorectum | AD | axon guidance | 64/3918 | 227/18723 | 5.41e-03 | 3.55e-02 | 64 |
| GO:0097485 | Colorectum | AD | neuron projection guidance | 64/3918 | 228/18723 | 6.02e-03 | 3.78e-02 | 64 |
| GO:00074111 | Colorectum | SER | axon guidance | 51/2897 | 227/18723 | 3.29e-03 | 2.82e-02 | 51 |
| GO:00974851 | Colorectum | SER | neuron projection guidance | 51/2897 | 228/18723 | 3.61e-03 | 3.03e-02 | 51 |
| GO:00615641 | Colorectum | SER | axon development | 94/2897 | 467/18723 | 3.78e-03 | 3.13e-02 | 94 |
| GO:00074091 | Colorectum | SER | axonogenesis | 84/2897 | 418/18723 | 6.20e-03 | 4.49e-02 | 84 |
| GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
| GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04360 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
| hsa043601 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
| hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
| hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| UNC5D | SNV | Missense_Mutation | c.1639N>T | p.Val547Phe | p.V547F | Q6UXZ4 | protein_coding | deleterious(0.03) | possibly_damaging(0.462) | TCGA-A1-A0SK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| UNC5D | SNV | Missense_Mutation | c.730N>A | p.Ser244Thr | p.S244T | Q6UXZ4 | protein_coding | tolerated(1) | benign(0.005) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
| UNC5D | SNV | Missense_Mutation | c.983G>A | p.Arg328Gln | p.R328Q | Q6UXZ4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
| UNC5D | SNV | Missense_Mutation | novel | c.1883N>A | p.Ser628Tyr | p.S628Y | Q6UXZ4 | protein_coding | deleterious(0.02) | possibly_damaging(0.686) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| UNC5D | SNV | Missense_Mutation | c.1672C>T | p.Pro558Ser | p.P558S | Q6UXZ4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| UNC5D | SNV | Missense_Mutation | c.1959N>T | p.Glu653Asp | p.E653D | Q6UXZ4 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| UNC5D | SNV | Missense_Mutation | c.731N>T | p.Ser244Leu | p.S244L | Q6UXZ4 | protein_coding | deleterious(0.01) | benign(0.136) | TCGA-B6-A0RL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| UNC5D | SNV | Missense_Mutation | c.1987N>A | p.Pro663Thr | p.P663T | Q6UXZ4 | protein_coding | tolerated(0.16) | benign(0) | TCGA-B6-A0RU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| UNC5D | SNV | Missense_Mutation | c.2206N>A | p.Glu736Lys | p.E736K | Q6UXZ4 | protein_coding | deleterious(0.01) | benign(0.283) | TCGA-B6-A0WZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| UNC5D | SNV | Missense_Mutation | c.637N>A | p.Asp213Asn | p.D213N | Q6UXZ4 | protein_coding | deleterious(0.04) | possibly_damaging(0.65) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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