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Gene: UNC5CL |
Gene summary for UNC5CL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | UNC5CL | Gene ID | 222643 |
| Gene name | unc-5 family C-terminal like | |
| Gene Alias | MUXA | |
| Cytomap | 6p21.1 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | H8YHX0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 222643 | UNC5CL | HCC1_Meng | Human | Liver | HCC | 1.08e-10 | -3.53e-02 | 0.0246 |
| 222643 | UNC5CL | HCC2_Meng | Human | Liver | HCC | 2.66e-21 | 1.43e-01 | 0.0107 |
| 222643 | UNC5CL | S027 | Human | Liver | HCC | 2.54e-05 | 6.24e-01 | 0.2446 |
| 222643 | UNC5CL | S028 | Human | Liver | HCC | 1.28e-07 | 5.74e-01 | 0.2503 |
| 222643 | UNC5CL | S029 | Human | Liver | HCC | 3.43e-06 | 5.27e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
| GO:004312312 | Liver | HCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 108/7958 | 186/18723 | 1.28e-05 | 1.43e-04 | 108 |
| GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
| GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
| GO:004312212 | Liver | HCC | regulation of I-kappaB kinase/NF-kappaB signaling | 138/7958 | 249/18723 | 2.47e-05 | 2.58e-04 | 138 |
| GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
| GO:003287222 | Liver | HCC | regulation of stress-activated MAPK cascade | 102/7958 | 192/18723 | 1.86e-03 | 9.49e-03 | 102 |
| GO:000725412 | Liver | HCC | JNK cascade | 89/7958 | 167/18723 | 3.09e-03 | 1.44e-02 | 89 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| UNC5CL | SNV | Missense_Mutation | c.721N>T | p.Arg241Cys | p.R241C | Q8IV45 | protein_coding | tolerated(0.19) | benign(0) | TCGA-C8-A131-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
| UNC5CL | deletion | Frame_Shift_Del | rs748733935 | c.175delN | p.Gln59AsnfsTer2 | p.Q59Nfs*2 | Q8IV45 | protein_coding | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| UNC5CL | SNV | Missense_Mutation | c.1504N>A | p.Glu502Lys | p.E502K | Q8IV45 | protein_coding | tolerated_low_confidence(0.85) | benign(0.003) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
| UNC5CL | SNV | Missense_Mutation | c.721N>T | p.Arg241Cys | p.R241C | Q8IV45 | protein_coding | tolerated(0.19) | benign(0) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| UNC5CL | SNV | Missense_Mutation | c.772N>T | p.Pro258Ser | p.P258S | Q8IV45 | protein_coding | tolerated(0.27) | benign(0.003) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| UNC5CL | SNV | Missense_Mutation | c.448N>A | p.Ala150Thr | p.A150T | Q8IV45 | protein_coding | tolerated(0.45) | possibly_damaging(0.487) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| UNC5CL | SNV | Missense_Mutation | rs529775453 | c.869N>A | p.Arg290His | p.R290H | Q8IV45 | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| UNC5CL | SNV | Missense_Mutation | c.1439G>A | p.Arg480Gln | p.R480Q | Q8IV45 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| UNC5CL | SNV | Missense_Mutation | rs775714807 | c.280C>T | p.Arg94Cys | p.R94C | Q8IV45 | protein_coding | deleterious(0) | possibly_damaging(0.451) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| UNC5CL | SNV | Missense_Mutation | rs765497708 | c.413G>A | p.Arg138Gln | p.R138Q | Q8IV45 | protein_coding | tolerated(0.53) | benign(0.015) | TCGA-D5-5540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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