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Gene: ULBP2 |
Gene summary for ULBP2 |
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Gene information | Species | Human | Gene symbol | ULBP2 | Gene ID | 80328 |
Gene name | UL16 binding protein 2 | |
Gene Alias | ALCAN-alpha | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9BZM5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80328 | ULBP2 | LZE4T | Human | Esophagus | ESCC | 1.19e-10 | 3.60e-01 | 0.0811 |
80328 | ULBP2 | LZE7T | Human | Esophagus | ESCC | 1.08e-15 | 6.66e-01 | 0.0667 |
80328 | ULBP2 | LZE8T | Human | Esophagus | ESCC | 1.08e-04 | 2.24e-01 | 0.067 |
80328 | ULBP2 | LZE24T | Human | Esophagus | ESCC | 1.15e-24 | 9.88e-01 | 0.0596 |
80328 | ULBP2 | LZE21T | Human | Esophagus | ESCC | 1.28e-02 | 2.10e-01 | 0.0655 |
80328 | ULBP2 | LZE6T | Human | Esophagus | ESCC | 7.60e-03 | 2.15e-01 | 0.0845 |
80328 | ULBP2 | P1T-E | Human | Esophagus | ESCC | 1.97e-04 | 3.95e-01 | 0.0875 |
80328 | ULBP2 | P2T-E | Human | Esophagus | ESCC | 8.17e-09 | 1.35e-01 | 0.1177 |
80328 | ULBP2 | P4T-E | Human | Esophagus | ESCC | 4.17e-44 | 1.05e+00 | 0.1323 |
80328 | ULBP2 | P5T-E | Human | Esophagus | ESCC | 1.11e-62 | 1.14e+00 | 0.1327 |
80328 | ULBP2 | P8T-E | Human | Esophagus | ESCC | 1.20e-18 | 3.68e-01 | 0.0889 |
80328 | ULBP2 | P10T-E | Human | Esophagus | ESCC | 6.24e-14 | 2.26e-01 | 0.116 |
80328 | ULBP2 | P11T-E | Human | Esophagus | ESCC | 6.32e-15 | 7.97e-01 | 0.1426 |
80328 | ULBP2 | P12T-E | Human | Esophagus | ESCC | 3.07e-09 | 2.45e-01 | 0.1122 |
80328 | ULBP2 | P15T-E | Human | Esophagus | ESCC | 2.20e-09 | 2.16e-01 | 0.1149 |
80328 | ULBP2 | P16T-E | Human | Esophagus | ESCC | 1.85e-12 | 1.97e-01 | 0.1153 |
80328 | ULBP2 | P17T-E | Human | Esophagus | ESCC | 5.81e-04 | 2.79e-01 | 0.1278 |
80328 | ULBP2 | P20T-E | Human | Esophagus | ESCC | 4.28e-07 | 1.13e-01 | 0.1124 |
80328 | ULBP2 | P21T-E | Human | Esophagus | ESCC | 9.33e-50 | 1.03e+00 | 0.1617 |
80328 | ULBP2 | P22T-E | Human | Esophagus | ESCC | 6.33e-05 | 1.24e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ULBP2 | SNV | Missense_Mutation | c.460N>A | p.Glu154Lys | p.E154K | Q9BZM5 | protein_coding | tolerated(0.09) | benign(0.326) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ULBP2 | SNV | Missense_Mutation | c.545T>C | p.Phe182Ser | p.F182S | Q9BZM5 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ULBP2 | SNV | Missense_Mutation | novel | c.448N>G | p.Leu150Val | p.L150V | Q9BZM5 | protein_coding | tolerated(0.06) | possibly_damaging(0.897) | TCGA-LL-A5YO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ULBP2 | insertion | Frame_Shift_Ins | novel | c.625_626insTGTT | p.Ala209ValfsTer45 | p.A209Vfs*45 | Q9BZM5 | protein_coding | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ULBP2 | insertion | In_Frame_Ins | novel | c.626_627insTGGATTTTCACACTT | p.Gly210_Ala211insPheSerHisLeuGly | p.G210_A211insFSHLG | Q9BZM5 | protein_coding | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ULBP2 | SNV | Missense_Mutation | c.261G>C | p.Trp87Cys | p.W87C | Q9BZM5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
ULBP2 | insertion | Frame_Shift_Ins | novel | c.445_446insCATTTGTA | p.Leu149ProfsTer23 | p.L149Pfs*23 | Q9BZM5 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
ULBP2 | SNV | Missense_Mutation | c.277N>T | p.Val93Leu | p.V93L | Q9BZM5 | protein_coding | deleterious(0.03) | benign(0.345) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ULBP2 | SNV | Missense_Mutation | c.404N>A | p.Ser135Asn | p.S135N | Q9BZM5 | protein_coding | tolerated(0.14) | benign(0.395) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ULBP2 | SNV | Missense_Mutation | c.467G>T | p.Arg156Ile | p.R156I | Q9BZM5 | protein_coding | tolerated(0.07) | possibly_damaging(0.744) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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