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Gene: UFD1L |
Gene summary for UFD1L |
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Gene information | Species | Human | Gene symbol | UFD1L | Gene ID | 7353 |
Gene name | ubiquitin recognition factor in ER associated degradation 1 | |
Gene Alias | UFD1L | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q92890 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7353 | UFD1L | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.12e-26 | 5.49e-01 | 0.294 |
7353 | UFD1L | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.89e-11 | 1.14e+00 | 0.3487 |
7353 | UFD1L | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.91e-05 | 2.02e-01 | 0.281 |
7353 | UFD1L | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.17e-24 | 4.84e-01 | 0.3859 |
7353 | UFD1L | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.22e-05 | 2.55e-01 | 0.2585 |
7353 | UFD1L | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.94e-11 | 2.25e-01 | 0.3005 |
7353 | UFD1L | LZE24T | Human | Esophagus | ESCC | 1.83e-03 | -1.97e-01 | 0.0596 |
7353 | UFD1L | P1T-E | Human | Esophagus | ESCC | 1.25e-04 | 7.81e-01 | 0.0875 |
7353 | UFD1L | P2T-E | Human | Esophagus | ESCC | 3.27e-30 | 6.15e-01 | 0.1177 |
7353 | UFD1L | P4T-E | Human | Esophagus | ESCC | 4.20e-36 | 1.33e+00 | 0.1323 |
7353 | UFD1L | P5T-E | Human | Esophagus | ESCC | 6.25e-64 | 1.40e+00 | 0.1327 |
7353 | UFD1L | P8T-E | Human | Esophagus | ESCC | 3.73e-29 | 7.22e-01 | 0.0889 |
7353 | UFD1L | P9T-E | Human | Esophagus | ESCC | 8.67e-32 | 1.07e+00 | 0.1131 |
7353 | UFD1L | P10T-E | Human | Esophagus | ESCC | 5.26e-65 | 1.37e+00 | 0.116 |
7353 | UFD1L | P11T-E | Human | Esophagus | ESCC | 5.16e-25 | 1.33e+00 | 0.1426 |
7353 | UFD1L | P12T-E | Human | Esophagus | ESCC | 8.61e-46 | 9.47e-01 | 0.1122 |
7353 | UFD1L | P15T-E | Human | Esophagus | ESCC | 1.69e-27 | 9.00e-01 | 0.1149 |
7353 | UFD1L | P16T-E | Human | Esophagus | ESCC | 5.03e-30 | 6.81e-01 | 0.1153 |
7353 | UFD1L | P17T-E | Human | Esophagus | ESCC | 2.45e-19 | 1.31e+00 | 0.1278 |
7353 | UFD1L | P19T-E | Human | Esophagus | ESCC | 1.05e-07 | 1.36e+00 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414139 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa04141114 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UFD1L | SNV | Missense_Mutation | novel | c.152N>T | p.Ser51Leu | p.S51L | Q92890 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
UFD1L | SNV | Missense_Mutation | rs767966094 | c.29N>G | p.Pro10Arg | p.P10R | Q92890 | protein_coding | tolerated(0.28) | benign(0.019) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
UFD1L | SNV | Missense_Mutation | c.480N>G | p.Ile160Met | p.I160M | Q92890 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
UFD1L | SNV | Missense_Mutation | c.265N>A | p.Glu89Lys | p.E89K | Q92890 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
UFD1L | SNV | Missense_Mutation | c.433G>A | p.Ala145Thr | p.A145T | Q92890 | protein_coding | deleterious(0.03) | benign(0.009) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
UFD1L | SNV | Missense_Mutation | novel | c.572T>G | p.Phe191Cys | p.F191C | Q92890 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UFD1L | SNV | Missense_Mutation | novel | c.502G>A | p.Glu168Lys | p.E168K | Q92890 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UFD1L | SNV | Missense_Mutation | novel | c.57C>A | p.Phe19Leu | p.F19L | Q92890 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UFD1L | SNV | Missense_Mutation | novel | c.191N>A | p.Pro64His | p.P64H | Q92890 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UFD1L | SNV | Missense_Mutation | novel | c.871G>A | p.Val291Ile | p.V291I | Q92890 | protein_coding | tolerated(0.2) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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