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Gene: UBXN6 |
Gene summary for UBXN6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | UBXN6 | Gene ID | 80700 |
| Gene name | UBX domain protein 6 | |
| Gene Alias | UBXD1 | |
| Cytomap | 19p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9BZV1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 80700 | UBXN6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.39e-06 | 2.77e-01 | -0.1808 |
| 80700 | UBXN6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.11e-07 | 2.90e-01 | -0.0811 |
| 80700 | UBXN6 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.49e-02 | 1.92e-01 | -0.1088 |
| 80700 | UBXN6 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.92e-11 | 2.66e-01 | -0.1954 |
| 80700 | UBXN6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.76e-04 | 2.38e-01 | -0.1207 |
| 80700 | UBXN6 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.21e-09 | 2.84e-01 | -0.1464 |
| 80700 | UBXN6 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.52e-06 | 2.41e-01 | -0.1001 |
| 80700 | UBXN6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.73e-12 | 3.17e-01 | -0.059 |
| 80700 | UBXN6 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.51e-04 | 3.08e-01 | -0.1706 |
| 80700 | UBXN6 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.64e-04 | 3.12e-01 | -0.2061 |
| 80700 | UBXN6 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.22e-03 | 2.33e-01 | -0.0842 |
| 80700 | UBXN6 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.01e-04 | 1.12e-01 | 0.096 |
| 80700 | UBXN6 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.60e-04 | 2.17e-01 | 0.0528 |
| 80700 | UBXN6 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.73e-10 | 5.36e-01 | -0.0177 |
| 80700 | UBXN6 | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.25e-03 | 4.77e-01 | 0.0171 |
| 80700 | UBXN6 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.16e-05 | 2.83e-01 | 0.0338 |
| 80700 | UBXN6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.33e-08 | 2.74e-01 | 0.0674 |
| 80700 | UBXN6 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.51e-03 | 2.73e-01 | 0.0112 |
| 80700 | UBXN6 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.07e-05 | 1.60e-01 | 0.0588 |
| 80700 | UBXN6 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.08e-09 | 8.17e-01 | 0.3487 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
| GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
| GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
| GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
| GO:0007034 | Colorectum | AD | vacuolar transport | 60/3918 | 157/18723 | 4.97e-07 | 1.85e-05 | 60 |
| GO:0071985 | Colorectum | AD | multivesicular body sorting pathway | 19/3918 | 37/18723 | 4.08e-05 | 7.26e-04 | 19 |
| GO:0007041 | Colorectum | AD | lysosomal transport | 42/3918 | 114/18723 | 6.61e-05 | 1.07e-03 | 42 |
| GO:0032509 | Colorectum | AD | endosome transport via multivesicular body sorting pathway | 16/3918 | 31/18723 | 1.53e-04 | 2.16e-03 | 16 |
| GO:0036503 | Colorectum | AD | ERAD pathway | 34/3918 | 107/18723 | 5.57e-03 | 3.63e-02 | 34 |
| GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
| GO:00349761 | Colorectum | SER | response to endoplasmic reticulum stress | 74/2897 | 256/18723 | 3.01e-08 | 2.05e-06 | 74 |
| GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
| GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
| GO:00719851 | Colorectum | SER | multivesicular body sorting pathway | 17/2897 | 37/18723 | 1.12e-05 | 3.60e-04 | 17 |
| GO:00325091 | Colorectum | SER | endosome transport via multivesicular body sorting pathway | 15/2897 | 31/18723 | 1.70e-05 | 5.11e-04 | 15 |
| GO:00070341 | Colorectum | SER | vacuolar transport | 43/2897 | 157/18723 | 8.92e-05 | 1.93e-03 | 43 |
| GO:00365031 | Colorectum | SER | ERAD pathway | 28/2897 | 107/18723 | 2.92e-03 | 2.59e-02 | 28 |
| GO:00104982 | Colorectum | MSS | proteasomal protein catabolic process | 157/3467 | 490/18723 | 2.39e-13 | 5.25e-11 | 157 |
| GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
| GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
| hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
| hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
| hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
| hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
| hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
| hsa041416 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
| hsa041417 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
| hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
| hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
| hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
| hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
| hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
| hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
| hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
| hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
| hsa04141210 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
| hsa0414138 | Oral cavity | LP | Protein processing in endoplasmic reticulum | 113/2418 | 174/8465 | 8.74e-24 | 5.82e-22 | 3.76e-22 | 113 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| UBXN6 | SNV | Missense_Mutation | rs8101961 | c.788N>T | p.Ala263Val | p.A263V | Q9BZV1 | protein_coding | deleterious(0) | possibly_damaging(0.494) | TCGA-LD-A7W6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | letrozole | SD |
| UBXN6 | deletion | Frame_Shift_Del | novel | c.919delN | p.Arg307GlyfsTer8 | p.R307Gfs*8 | Q9BZV1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| UBXN6 | deletion | Frame_Shift_Del | c.547delN | p.Asp183ThrfsTer60 | p.D183Tfs*60 | Q9BZV1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
| UBXN6 | SNV | Missense_Mutation | rs763974738 | c.1312N>A | p.Glu438Lys | p.E438K | Q9BZV1 | protein_coding | tolerated(0.15) | benign(0.041) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| UBXN6 | SNV | Missense_Mutation | rs193168940 | c.415G>A | p.Ala139Thr | p.A139T | Q9BZV1 | protein_coding | tolerated(0.14) | benign(0.046) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| UBXN6 | SNV | Missense_Mutation | novel | c.17A>G | p.Gln6Arg | p.Q6R | Q9BZV1 | protein_coding | deleterious(0.02) | benign(0.366) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| UBXN6 | SNV | Missense_Mutation | rs141123683 | c.239G>A | p.Arg80Gln | p.R80Q | Q9BZV1 | protein_coding | tolerated(0.44) | benign(0.079) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| UBXN6 | SNV | Missense_Mutation | c.475A>T | p.Met159Leu | p.M159L | Q9BZV1 | protein_coding | tolerated(0.44) | benign(0.034) | TCGA-AU-3779-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| UBXN6 | SNV | Missense_Mutation | rs534985329 | c.823N>T | p.Arg275Cys | p.R275C | Q9BZV1 | protein_coding | tolerated(0.16) | benign(0.027) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| UBXN6 | SNV | Missense_Mutation | rs267605469 | c.968N>A | p.Arg323Gln | p.R323Q | Q9BZV1 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-CM-6172-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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