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Gene: UBTD1 |
Gene summary for UBTD1 |
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Gene information | Species | Human | Gene symbol | UBTD1 | Gene ID | 80019 |
Gene name | ubiquitin domain containing 1 | |
Gene Alias | UBTD1 | |
Cytomap | 10q24.1-q24.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9HAC8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80019 | UBTD1 | LZE24T | Human | Esophagus | ESCC | 2.31e-16 | 4.20e-01 | 0.0596 |
80019 | UBTD1 | P2T-E | Human | Esophagus | ESCC | 4.96e-12 | 2.47e-01 | 0.1177 |
80019 | UBTD1 | P4T-E | Human | Esophagus | ESCC | 1.79e-21 | 4.73e-01 | 0.1323 |
80019 | UBTD1 | P8T-E | Human | Esophagus | ESCC | 2.15e-18 | 2.69e-01 | 0.0889 |
80019 | UBTD1 | P9T-E | Human | Esophagus | ESCC | 1.52e-10 | 2.60e-01 | 0.1131 |
80019 | UBTD1 | P11T-E | Human | Esophagus | ESCC | 3.94e-19 | 6.38e-01 | 0.1426 |
80019 | UBTD1 | P12T-E | Human | Esophagus | ESCC | 2.78e-03 | 1.63e-01 | 0.1122 |
80019 | UBTD1 | P15T-E | Human | Esophagus | ESCC | 3.96e-13 | 2.49e-01 | 0.1149 |
80019 | UBTD1 | P16T-E | Human | Esophagus | ESCC | 7.27e-09 | 1.69e-01 | 0.1153 |
80019 | UBTD1 | P17T-E | Human | Esophagus | ESCC | 4.02e-05 | 2.90e-01 | 0.1278 |
80019 | UBTD1 | P19T-E | Human | Esophagus | ESCC | 6.62e-14 | 6.24e-01 | 0.1662 |
80019 | UBTD1 | P20T-E | Human | Esophagus | ESCC | 2.38e-11 | 2.89e-01 | 0.1124 |
80019 | UBTD1 | P21T-E | Human | Esophagus | ESCC | 1.90e-21 | 4.05e-01 | 0.1617 |
80019 | UBTD1 | P22T-E | Human | Esophagus | ESCC | 9.71e-06 | 1.93e-01 | 0.1236 |
80019 | UBTD1 | P23T-E | Human | Esophagus | ESCC | 4.81e-26 | 5.35e-01 | 0.108 |
80019 | UBTD1 | P24T-E | Human | Esophagus | ESCC | 6.16e-14 | 3.16e-01 | 0.1287 |
80019 | UBTD1 | P26T-E | Human | Esophagus | ESCC | 1.89e-26 | 5.13e-01 | 0.1276 |
80019 | UBTD1 | P27T-E | Human | Esophagus | ESCC | 7.75e-26 | 4.63e-01 | 0.1055 |
80019 | UBTD1 | P28T-E | Human | Esophagus | ESCC | 8.66e-10 | 2.71e-01 | 0.1149 |
80019 | UBTD1 | P30T-E | Human | Esophagus | ESCC | 2.80e-11 | 3.67e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBTD1 | SNV | Missense_Mutation | rs759421272 | c.514N>A | p.Gly172Arg | p.G172R | Q9HAC8 | protein_coding | tolerated(0.33) | benign(0.055) | TCGA-C5-A7CG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UBTD1 | SNV | Missense_Mutation | rs559667337 | c.493G>A | p.Ala165Thr | p.A165T | Q9HAC8 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UBTD1 | SNV | Missense_Mutation | novel | c.472G>C | p.Gly158Arg | p.G158R | Q9HAC8 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
UBTD1 | SNV | Missense_Mutation | c.463C>A | p.Leu155Met | p.L155M | Q9HAC8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
UBTD1 | SNV | Missense_Mutation | c.335N>A | p.Arg112His | p.R112H | Q9HAC8 | protein_coding | tolerated(0.15) | probably_damaging(0.97) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
UBTD1 | SNV | Missense_Mutation | c.335N>A | p.Arg112His | p.R112H | Q9HAC8 | protein_coding | tolerated(0.15) | probably_damaging(0.97) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UBTD1 | SNV | Missense_Mutation | c.509N>T | p.Thr170Ile | p.T170I | Q9HAC8 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UBTD1 | SNV | Missense_Mutation | rs146047099 | c.368C>T | p.Pro123Leu | p.P123L | Q9HAC8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DC-5337-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UBTD1 | SNV | Missense_Mutation | novel | c.396N>T | p.Glu132Asp | p.E132D | Q9HAC8 | protein_coding | tolerated(0.68) | benign(0.003) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
UBTD1 | SNV | Missense_Mutation | c.335N>A | p.Arg112His | p.R112H | Q9HAC8 | protein_coding | tolerated(0.15) | probably_damaging(0.97) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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