![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: UBFD1 |
Gene summary for UBFD1 |
![]() |
Gene information | Species | Human | Gene symbol | UBFD1 | Gene ID | 56061 |
Gene name | ubiquitin family domain containing 1 | |
Gene Alias | UBPH | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | O14562 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56061 | UBFD1 | LZE2T | Human | Esophagus | ESCC | 6.29e-03 | 3.02e-01 | 0.082 |
56061 | UBFD1 | LZE7T | Human | Esophagus | ESCC | 4.45e-07 | 2.57e-01 | 0.0667 |
56061 | UBFD1 | LZE20T | Human | Esophagus | ESCC | 5.42e-03 | 1.15e-01 | 0.0662 |
56061 | UBFD1 | LZE24T | Human | Esophagus | ESCC | 2.39e-06 | 9.60e-02 | 0.0596 |
56061 | UBFD1 | P1T-E | Human | Esophagus | ESCC | 1.89e-02 | 1.43e-01 | 0.0875 |
56061 | UBFD1 | P2T-E | Human | Esophagus | ESCC | 2.19e-36 | 6.13e-01 | 0.1177 |
56061 | UBFD1 | P4T-E | Human | Esophagus | ESCC | 1.26e-20 | 4.78e-01 | 0.1323 |
56061 | UBFD1 | P5T-E | Human | Esophagus | ESCC | 1.48e-23 | 4.01e-01 | 0.1327 |
56061 | UBFD1 | P8T-E | Human | Esophagus | ESCC | 1.46e-15 | 2.83e-01 | 0.0889 |
56061 | UBFD1 | P9T-E | Human | Esophagus | ESCC | 1.56e-05 | 8.15e-02 | 0.1131 |
56061 | UBFD1 | P10T-E | Human | Esophagus | ESCC | 2.97e-17 | 1.52e-01 | 0.116 |
56061 | UBFD1 | P11T-E | Human | Esophagus | ESCC | 5.39e-10 | 3.28e-01 | 0.1426 |
56061 | UBFD1 | P12T-E | Human | Esophagus | ESCC | 1.74e-13 | 2.40e-01 | 0.1122 |
56061 | UBFD1 | P15T-E | Human | Esophagus | ESCC | 6.65e-08 | 1.92e-01 | 0.1149 |
56061 | UBFD1 | P16T-E | Human | Esophagus | ESCC | 1.56e-23 | 2.88e-01 | 0.1153 |
56061 | UBFD1 | P20T-E | Human | Esophagus | ESCC | 6.54e-09 | 1.66e-01 | 0.1124 |
56061 | UBFD1 | P21T-E | Human | Esophagus | ESCC | 1.62e-15 | 1.25e-01 | 0.1617 |
56061 | UBFD1 | P22T-E | Human | Esophagus | ESCC | 1.71e-23 | 3.25e-01 | 0.1236 |
56061 | UBFD1 | P23T-E | Human | Esophagus | ESCC | 1.01e-21 | 3.27e-01 | 0.108 |
56061 | UBFD1 | P24T-E | Human | Esophagus | ESCC | 5.90e-13 | 1.94e-01 | 0.1287 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBFD1 | SNV | Missense_Mutation | c.587A>G | p.Lys196Arg | p.K196R | O14562 | protein_coding | tolerated(0.12) | benign(0.074) | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBFD1 | deletion | Frame_Shift_Del | novel | c.639delG | p.Pro214GlnfsTer16 | p.P214Qfs*16 | O14562 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
UBFD1 | SNV | Missense_Mutation | rs756180251 | c.635G>A | p.Arg212His | p.R212H | O14562 | protein_coding | tolerated(0.21) | benign(0) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
UBFD1 | SNV | Missense_Mutation | c.754N>T | p.Pro252Ser | p.P252S | O14562 | protein_coding | tolerated(0.08) | benign(0.122) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
UBFD1 | SNV | Missense_Mutation | c.898N>T | p.Asp300Tyr | p.D300Y | O14562 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
UBFD1 | SNV | Missense_Mutation | novel | c.926T>G | p.Phe309Cys | p.F309C | O14562 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
UBFD1 | SNV | Missense_Mutation | c.301T>C | p.Phe101Leu | p.F101L | O14562 | protein_coding | tolerated(0.43) | benign(0.001) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UBFD1 | SNV | Missense_Mutation | c.839N>T | p.Thr280Met | p.T280M | O14562 | protein_coding | deleterious(0) | possibly_damaging(0.878) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBFD1 | SNV | Missense_Mutation | novel | c.793N>A | p.Glu265Lys | p.E265K | O14562 | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBFD1 | SNV | Missense_Mutation | c.805N>A | p.Asp269Asn | p.D269N | O14562 | protein_coding | deleterious(0.01) | possibly_damaging(0.766) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |