Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: UBE3A

Gene summary for UBE3A

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

UBE3A

Gene ID

7337

Gene nameubiquitin protein ligase E3A
Gene AliasANCR
Cytomap15q11.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q05086


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7337UBE3ACA_HPV_1HumanCervixCC2.38e-03-6.62e-020.0264
7337UBE3ACCI_2HumanCervixCC2.04e-171.43e+000.5249
7337UBE3AL1HumanCervixCC4.45e-05-1.37e-010.0802
7337UBE3AHTA11_3410_2000001011HumanColorectumAD1.34e-39-9.07e-010.0155
7337UBE3AHTA11_2487_2000001011HumanColorectumSER3.48e-22-8.72e-01-0.1808
7337UBE3AHTA11_2951_2000001011HumanColorectumAD3.36e-07-9.54e-010.0216
7337UBE3AHTA11_1938_2000001011HumanColorectumAD7.66e-09-6.90e-01-0.0811
7337UBE3AHTA11_78_2000001011HumanColorectumAD7.40e-08-5.46e-01-0.1088
7337UBE3AHTA11_347_2000001011HumanColorectumAD1.69e-17-5.66e-01-0.1954
7337UBE3AHTA11_411_2000001011HumanColorectumSER1.03e-02-8.13e-01-0.2602
7337UBE3AHTA11_2112_2000001011HumanColorectumSER1.79e-04-8.79e-01-0.2196
7337UBE3AHTA11_3361_2000001011HumanColorectumAD7.91e-15-8.20e-01-0.1207
7337UBE3AHTA11_83_2000001011HumanColorectumSER3.33e-12-7.84e-01-0.1526
7337UBE3AHTA11_696_2000001011HumanColorectumAD1.08e-40-8.38e-01-0.1464
7337UBE3AHTA11_866_2000001011HumanColorectumAD4.92e-31-7.29e-01-0.1001
7337UBE3AHTA11_1391_2000001011HumanColorectumAD7.63e-23-7.88e-01-0.059
7337UBE3AHTA11_2992_2000001011HumanColorectumSER1.15e-05-6.55e-01-0.1706
7337UBE3AHTA11_5212_2000001011HumanColorectumAD1.02e-06-8.18e-01-0.2061
7337UBE3AHTA11_5216_2000001011HumanColorectumSER1.79e-04-7.66e-01-0.1462
7337UBE3AHTA11_546_2000001011HumanColorectumAD1.17e-07-7.28e-01-0.0842
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004217610CervixCCregulation of protein catabolic process104/2311391/187239.39e-159.36e-12104
GO:190336210CervixCCregulation of cellular protein catabolic process72/2311255/187235.98e-122.10e-0972
GO:190332010CervixCCregulation of protein modification by small protein conjugation or removal66/2311242/187232.31e-103.46e-0866
GO:000697910CervixCCresponse to oxidative stress102/2311446/187232.99e-104.36e-08102
GO:003139610CervixCCregulation of protein ubiquitination59/2311210/187235.90e-107.51e-0859
GO:190305010CervixCCregulation of proteolysis involved in cellular protein catabolic process60/2311221/187231.82e-091.98e-0760
GO:200005810CervixCCregulation of ubiquitin-dependent protein catabolic process47/2311164/187231.63e-081.25e-0647
GO:000030210CervixCCresponse to reactive oxygen species56/2311222/187231.00e-075.25e-0656
GO:00002097CervixCCprotein polyubiquitination58/2311236/187231.57e-077.41e-0658
GO:00163587CervixCCdendrite development58/2311243/187234.52e-071.76e-0558
GO:004854510CervixCCresponse to steroid hormone74/2311339/187235.71e-072.09e-0574
GO:004254210CervixCCresponse to hydrogen peroxide40/2311146/187236.79e-072.46e-0540
GO:00614588CervixCCreproductive system development87/2311427/187231.37e-064.55e-0587
GO:00305229CervixCCintracellular receptor signaling pathway60/2311265/187231.89e-065.97e-0560
GO:00486088CervixCCreproductive structure development86/2311424/187231.90e-065.97e-0586
GO:00485118CervixCCrhythmic process65/2311298/187232.79e-068.04e-0565
GO:00109757CervixCCregulation of neuron projection development88/2311445/187234.26e-061.09e-0488
GO:00709366CervixCCprotein K48-linked ubiquitination22/231165/187235.56e-061.38e-0422
GO:00609965CervixCCdendritic spine development28/231199/187231.61e-053.15e-0428
GO:190165410CervixCCresponse to ketone45/2311194/187231.83e-053.44e-0445
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0412014CervixCCUbiquitin mediated proteolysis49/1267142/84654.26e-097.68e-084.54e-0849
hsa051657CervixCCHuman papillomavirus infection74/1267331/84651.70e-041.02e-036.03e-0474
hsa0412015CervixCCUbiquitin mediated proteolysis49/1267142/84654.26e-097.68e-084.54e-0849
hsa0516512CervixCCHuman papillomavirus infection74/1267331/84651.70e-041.02e-036.03e-0474
hsa04120ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa041201ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa041202ColorectumSERUbiquitin mediated proteolysis39/1580142/84656.18e-033.66e-022.66e-0239
hsa041203ColorectumSERUbiquitin mediated proteolysis39/1580142/84656.18e-033.66e-022.66e-0239
hsa041204ColorectumMSSUbiquitin mediated proteolysis55/1875142/84655.02e-066.00e-053.68e-0555
hsa041205ColorectumMSSUbiquitin mediated proteolysis55/1875142/84655.02e-066.00e-053.68e-0555
hsa041206ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041207ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041208ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa041209ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa052039EsophagusHGINViral carcinogenesis53/1383204/84652.58e-042.71e-032.15e-0353
hsa0520315EsophagusHGINViral carcinogenesis53/1383204/84652.58e-042.71e-032.15e-0353
hsa0412027EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
hsa0516510EsophagusESCCHuman papillomavirus infection215/4205331/84657.86e-097.12e-083.65e-08215
hsa0520325EsophagusESCCViral carcinogenesis137/4205204/84652.47e-071.88e-069.62e-07137
hsa0412036EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
UBE3ASNVMissense_Mutationnovelc.2381N>Ap.Val794Aspp.V794DQ05086protein_codingdeleterious(0)probably_damaging(0.982)TCGA-A7-A4SE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
UBE3ASNVMissense_Mutationnovelc.253C>Tp.Pro85Serp.P85SQ05086protein_codingtolerated(0.5)benign(0.001)TCGA-AC-A62V-01Breastbreast invasive carcinomaMale<65III/IVTargeted Molecular therapydenosumabPD
UBE3ASNVMissense_Mutationc.1005N>Cp.Gln335Hisp.Q335HQ05086protein_codingtolerated(0.52)benign(0.003)TCGA-AR-A1AK-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
UBE3AinsertionNonsense_Mutationnovelc.123_124insTTGTTGCTTCAGAGTGTATAATp.Glu42LeufsTer7p.E42Lfs*7Q05086protein_codingTCGA-AO-A03T-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
UBE3AdeletionFrame_Shift_Delc.1990delNp.Asp664IlefsTer13p.D664Ifs*13Q05086protein_codingTCGA-BH-A0C0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycarboplatinSD
UBE3AdeletionFrame_Shift_Delc.2436_2446delNNNNNNNNNNNp.Asp813CysfsTer29p.D813Cfs*29Q05086protein_codingTCGA-E9-A249-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
UBE3ASNVMissense_Mutationnovelc.1265N>Ap.Gly422Aspp.G422DQ05086protein_codingtolerated(0.58)possibly_damaging(0.521)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
UBE3ASNVMissense_Mutationnovelc.214N>Tp.Ala72Serp.A72SQ05086protein_codingtolerated(0.08)probably_damaging(0.915)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
UBE3ASNVMissense_Mutationnovelc.272G>Ap.Gly91Glup.G91EQ05086protein_codingtolerated(1)benign(0.001)TCGA-C5-A1BL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
UBE3ASNVMissense_Mutationc.1195G>Cp.Glu399Glnp.E399QQ05086protein_codingtolerated(0.2)benign(0.135)TCGA-C5-A1BQ-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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