![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: UBE2U |
Gene summary for UBE2U |
![]() |
Gene information | Species | Human | Gene symbol | UBE2U | Gene ID | 148581 |
Gene name | ubiquitin conjugating enzyme E2 U | |
Gene Alias | UBE2U | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | A0A140VJY9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148581 | UBE2U | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-08 | 3.34e-01 | 0.0131 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE2U | SNV | Missense_Mutation | novel | c.508A>G | p.Ser170Gly | p.S170G | protein_coding | tolerated(0.28) | benign(0.089) | TCGA-UL-AAZ6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | herceptin | SD | |
UBE2U | SNV | Missense_Mutation | novel | c.366N>C | p.Glu122Asp | p.E122D | Q5VVX9 | protein_coding | tolerated(0.06) | benign(0.14) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UBE2U | SNV | Missense_Mutation | c.389C>T | p.Ala130Val | p.A130V | Q5VVX9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-A56B-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD | |
UBE2U | SNV | Missense_Mutation | c.227C>T | p.Pro76Leu | p.P76L | Q5VVX9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UBE2U | SNV | Missense_Mutation | novel | c.231N>G | p.Phe77Leu | p.F77L | Q5VVX9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE2U | SNV | Missense_Mutation | c.132N>T | p.Gln44His | p.Q44H | Q5VVX9 | protein_coding | deleterious(0.04) | probably_damaging(0.959) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
UBE2U | SNV | Missense_Mutation | rs771505279 | c.182N>T | p.Ser61Leu | p.S61L | Q5VVX9 | protein_coding | tolerated(0.12) | benign(0.023) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
UBE2U | SNV | Missense_Mutation | c.636N>T | p.Trp212Cys | p.W212C | Q5VVX9 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-F4-6461-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
UBE2U | SNV | Missense_Mutation | c.619N>A | p.Gly207Arg | p.G207R | Q5VVX9 | protein_coding | tolerated(0.12) | benign(0.438) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UBE2U | insertion | Frame_Shift_Ins | novel | c.137_138insTAAAAACTCTA | p.Val47LysfsTer9 | p.V47Kfs*9 | Q5VVX9 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |