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Gene: TXNDC5 |
Gene summary for TXNDC5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TXNDC5 | Gene ID | 81567 |
| Gene name | thioredoxin domain containing 5 | |
| Gene Alias | ENDOPDI | |
| Cytomap | 6p24.3 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024QZV0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 81567 | TXNDC5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.38e-10 | 2.03e-01 | 0.0155 |
| 81567 | TXNDC5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.80e-07 | 2.50e-01 | -0.1808 |
| 81567 | TXNDC5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.04e-15 | 4.80e-01 | -0.0811 |
| 81567 | TXNDC5 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.63e-17 | 4.49e-01 | -0.1088 |
| 81567 | TXNDC5 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.10e-17 | 3.32e-01 | -0.1954 |
| 81567 | TXNDC5 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 3.31e-01 | -0.2602 |
| 81567 | TXNDC5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 3.37e-01 | -0.2196 |
| 81567 | TXNDC5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-03 | 2.02e-01 | -0.1207 |
| 81567 | TXNDC5 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.64e-05 | 2.18e-01 | -0.1526 |
| 81567 | TXNDC5 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.73e-12 | 2.80e-01 | -0.1464 |
| 81567 | TXNDC5 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.05e-06 | 1.89e-01 | -0.1001 |
| 81567 | TXNDC5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.53e-27 | 7.20e-01 | -0.059 |
| 81567 | TXNDC5 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 2.63e-01 | -0.1706 |
| 81567 | TXNDC5 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.22e-01 | -0.1462 |
| 81567 | TXNDC5 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.71e-06 | 5.79e-01 | -0.0842 |
| 81567 | TXNDC5 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.55e-01 | -0.00410000000000005 |
| 81567 | TXNDC5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-06 | 2.70e-01 | -0.0179 |
| 81567 | TXNDC5 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.23e-22 | 4.77e-01 | 0.096 |
| 81567 | TXNDC5 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.51e-11 | 4.41e-01 | 0.0446 |
| 81567 | TXNDC5 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 2.67e-01 | 0.0528 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
| hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
| hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
| hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
| hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
| hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
| hsa041416 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
| hsa041417 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
| hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
| hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TXNDC5 | SNV | Missense_Mutation | novel | c.1204N>C | p.Phe402Leu | p.F402L | Q8NBS9 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-AC-A6IX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| TXNDC5 | SNV | Missense_Mutation | novel | c.1035T>G | p.Phe345Leu | p.F345L | Q8NBS9 | protein_coding | deleterious(0) | possibly_damaging(0.622) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TXNDC5 | SNV | Missense_Mutation | c.1190N>T | p.Pro397Leu | p.P397L | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
| TXNDC5 | SNV | Missense_Mutation | c.754G>C | p.Glu252Gln | p.E252Q | Q8NBS9 | protein_coding | tolerated(0.27) | benign(0.175) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| TXNDC5 | insertion | Nonsense_Mutation | novel | c.617-1_617insTGTAACTGGATTTTCTGGAAATATC | p.Gly206ValfsTer2 | p.G206Vfs*2 | Q8NBS9 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
| TXNDC5 | deletion | Frame_Shift_Del | c.818delN | p.Lys273ArgfsTer14 | p.K273Rfs*14 | Q8NBS9 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
| TXNDC5 | deletion | Frame_Shift_Del | c.397delN | p.Val133CysfsTer7 | p.V133Cfs*7 | Q8NBS9 | protein_coding | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |||
| TXNDC5 | SNV | Missense_Mutation | c.593N>C | p.Asn198Thr | p.N198T | Q8NBS9 | protein_coding | tolerated(0.58) | probably_damaging(0.999) | TCGA-R2-A69V-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
| TXNDC5 | SNV | Missense_Mutation | c.650N>A | p.Cys217Tyr | p.C217Y | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
| TXNDC5 | SNV | Missense_Mutation | rs530530741 | c.1291G>A | p.Glu431Lys | p.E431K | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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