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Gene: TWISTNB |
Gene summary for TWISTNB |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TWISTNB | Gene ID | 221830 |
| Gene name | RNA polymerase I subunit F | |
| Gene Alias | A43 | |
| Cytomap | 7p21.1 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q3B726 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 221830 | TWISTNB | LZE4T | Human | Esophagus | ESCC | 6.23e-06 | 5.04e-01 | 0.0811 |
| 221830 | TWISTNB | LZE5T | Human | Esophagus | ESCC | 2.41e-03 | 3.57e-01 | 0.0514 |
| 221830 | TWISTNB | LZE7T | Human | Esophagus | ESCC | 2.56e-11 | 4.01e-01 | 0.0667 |
| 221830 | TWISTNB | LZE8T | Human | Esophagus | ESCC | 9.45e-03 | 8.13e-02 | 0.067 |
| 221830 | TWISTNB | LZE20T | Human | Esophagus | ESCC | 1.89e-06 | 1.27e-01 | 0.0662 |
| 221830 | TWISTNB | LZE22T | Human | Esophagus | ESCC | 1.59e-03 | 4.47e-01 | 0.068 |
| 221830 | TWISTNB | LZE24T | Human | Esophagus | ESCC | 2.48e-10 | 3.62e-01 | 0.0596 |
| 221830 | TWISTNB | LZE21T | Human | Esophagus | ESCC | 1.42e-03 | 3.43e-01 | 0.0655 |
| 221830 | TWISTNB | LZE6T | Human | Esophagus | ESCC | 9.51e-10 | 1.78e-01 | 0.0845 |
| 221830 | TWISTNB | P1T-E | Human | Esophagus | ESCC | 5.87e-07 | 6.93e-01 | 0.0875 |
| 221830 | TWISTNB | P2T-E | Human | Esophagus | ESCC | 1.38e-20 | 6.14e-01 | 0.1177 |
| 221830 | TWISTNB | P4T-E | Human | Esophagus | ESCC | 3.46e-30 | 9.78e-01 | 0.1323 |
| 221830 | TWISTNB | P5T-E | Human | Esophagus | ESCC | 2.22e-20 | 5.03e-01 | 0.1327 |
| 221830 | TWISTNB | P8T-E | Human | Esophagus | ESCC | 1.08e-15 | 3.47e-01 | 0.0889 |
| 221830 | TWISTNB | P9T-E | Human | Esophagus | ESCC | 1.99e-08 | 4.12e-01 | 0.1131 |
| 221830 | TWISTNB | P10T-E | Human | Esophagus | ESCC | 3.80e-23 | 5.62e-01 | 0.116 |
| 221830 | TWISTNB | P11T-E | Human | Esophagus | ESCC | 9.45e-11 | 8.21e-01 | 0.1426 |
| 221830 | TWISTNB | P12T-E | Human | Esophagus | ESCC | 2.40e-15 | 5.38e-01 | 0.1122 |
| 221830 | TWISTNB | P15T-E | Human | Esophagus | ESCC | 9.70e-25 | 7.13e-01 | 0.1149 |
| 221830 | TWISTNB | P16T-E | Human | Esophagus | ESCC | 1.12e-23 | 5.34e-01 | 0.1153 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TWISTNB | SNV | Missense_Mutation | c.615N>G | p.Phe205Leu | p.F205L | Q3B726 | protein_coding | tolerated(0.84) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| TWISTNB | SNV | Missense_Mutation | novel | c.76C>A | p.Leu26Met | p.L26M | Q3B726 | protein_coding | deleterious(0.01) | probably_damaging(0.942) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| TWISTNB | SNV | Missense_Mutation | c.406A>T | p.Asn136Tyr | p.N136Y | Q3B726 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C8-A137-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| TWISTNB | SNV | Missense_Mutation | c.800C>G | p.Ala267Gly | p.A267G | Q3B726 | protein_coding | tolerated(0.09) | benign(0.021) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| TWISTNB | insertion | Frame_Shift_Ins | novel | c.45_46insCAGGCTG | p.Asp16GlnfsTer52 | p.D16Qfs*52 | Q3B726 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| TWISTNB | SNV | Missense_Mutation | novel | c.130N>T | p.Arg44Cys | p.R44C | Q3B726 | protein_coding | tolerated(0.06) | possibly_damaging(0.549) | TCGA-AF-4110-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | SD |
| TWISTNB | SNV | Missense_Mutation | c.989A>C | p.Lys330Thr | p.K330T | Q3B726 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.722) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TWISTNB | SNV | Missense_Mutation | c.938G>T | p.Arg313Ile | p.R313I | Q3B726 | protein_coding | deleterious(0) | possibly_damaging(0.539) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TWISTNB | insertion | Frame_Shift_Ins | rs775851473 | c.932_933insA | p.Lys312GlufsTer6 | p.K312Efs*6 | Q3B726 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| TWISTNB | insertion | Frame_Shift_Ins | rs775851473 | c.932_933insA | p.Lys312GlufsTer6 | p.K312Efs*6 | Q3B726 | protein_coding | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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