Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TUSC2

Gene summary for TUSC2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TUSC2

Gene ID

11334

Gene nametumor suppressor 2, mitochondrial calcium regulator
Gene AliasC3orf11
Cytomap3p21.31
Gene Typeprotein-coding
GO ID

GO:0001775

UniProtAcc

O75896


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11334TUSC2LZE2THumanEsophagusESCC7.07e-046.40e-010.082
11334TUSC2LZE4THumanEsophagusESCC1.98e-041.70e-010.0811
11334TUSC2LZE5THumanEsophagusESCC9.78e-053.28e-010.0514
11334TUSC2LZE7THumanEsophagusESCC1.60e-043.08e-010.0667
11334TUSC2LZE20THumanEsophagusESCC1.71e-021.13e-010.0662
11334TUSC2LZE22THumanEsophagusESCC8.31e-034.70e-010.068
11334TUSC2LZE24THumanEsophagusESCC3.29e-114.23e-010.0596
11334TUSC2LZE21THumanEsophagusESCC4.54e-052.91e-010.0655
11334TUSC2P1T-EHumanEsophagusESCC3.39e-043.72e-010.0875
11334TUSC2P2T-EHumanEsophagusESCC4.38e-203.25e-010.1177
11334TUSC2P4T-EHumanEsophagusESCC9.74e-358.47e-010.1323
11334TUSC2P5T-EHumanEsophagusESCC7.27e-274.86e-010.1327
11334TUSC2P8T-EHumanEsophagusESCC2.28e-192.81e-010.0889
11334TUSC2P9T-EHumanEsophagusESCC2.93e-142.41e-010.1131
11334TUSC2P10T-EHumanEsophagusESCC4.33e-254.13e-010.116
11334TUSC2P11T-EHumanEsophagusESCC1.65e-062.77e-010.1426
11334TUSC2P12T-EHumanEsophagusESCC1.40e-163.60e-010.1122
11334TUSC2P15T-EHumanEsophagusESCC4.39e-183.10e-010.1149
11334TUSC2P16T-EHumanEsophagusESCC4.48e-182.93e-010.1153
11334TUSC2P17T-EHumanEsophagusESCC1.94e-124.10e-010.1278
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0044403111EsophagusESCCbiological process involved in symbiotic interaction186/8552290/187231.43e-104.16e-09186
GO:200037718EsophagusESCCregulation of reactive oxygen species metabolic process100/8552157/187233.87e-064.17e-05100
GO:005188110EsophagusESCCregulation of mitochondrial membrane potential51/855274/187234.42e-053.51e-0451
GO:007259318EsophagusESCCreactive oxygen species metabolic process137/8552239/187231.82e-041.16e-03137
GO:19031317EsophagusESCCmononuclear cell differentiation226/8552426/187231.20e-035.88e-03226
GO:000181916EsophagusESCCpositive regulation of cytokine production244/8552467/187232.29e-031.01e-02244
GO:005170214EsophagusESCCbiological process involved in interaction with symbiont57/855294/187232.46e-031.07e-0257
GO:00300984EsophagusESCClymphocyte differentiation192/8552374/187231.52e-024.93e-02192
GO:004440312LiverCirrhoticbiological process involved in symbiotic interaction131/4634290/187232.00e-141.84e-12131
GO:005170211LiverCirrhoticbiological process involved in interaction with symbiont48/463494/187233.41e-081.14e-0648
GO:200037712LiverCirrhoticregulation of reactive oxygen species metabolic process67/4634157/187236.07e-071.32e-0567
GO:00725937LiverCirrhoticreactive oxygen species metabolic process92/4634239/187231.57e-063.03e-0592
GO:00518815LiverCirrhoticregulation of mitochondrial membrane potential30/463474/187231.97e-031.23e-0230
GO:004440322LiverHCCbiological process involved in symbiotic interaction183/7958290/187239.13e-134.59e-11183
GO:00517022LiverHCCbiological process involved in interaction with symbiont60/795894/187232.41e-052.54e-0460
GO:200037722LiverHCCregulation of reactive oxygen species metabolic process92/7958157/187233.34e-053.35e-0492
GO:005188112LiverHCCregulation of mitochondrial membrane potential45/795874/187231.13e-036.43e-0345
GO:007259312LiverHCCreactive oxygen species metabolic process124/7958239/187232.05e-031.04e-02124
GO:004440320Oral cavityOSCCbiological process involved in symbiotic interaction173/7305290/187236.80e-133.19e-11173
GO:200037716Oral cavityOSCCregulation of reactive oxygen species metabolic process92/7305157/187234.96e-077.27e-0692
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TUSC2SNVMissense_Mutationc.289C>Tp.Pro97Serp.P97SO75896protein_codingdeleterious(0.02)probably_damaging(0.996)TCGA-B5-A3FC-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
TUSC2SNVMissense_Mutationrs782369955c.226N>Tp.Arg76Trpp.R76WO75896protein_codingtolerated(0.07)possibly_damaging(0.895)TCGA-FI-A2D0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
11334TUSC2NACNVN-202
11334TUSC2NAFus-1 tumor suppressor gene therapy - nanoparticle formulation
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