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Gene: TUSC2 |
Gene summary for TUSC2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TUSC2 | Gene ID | 11334 |
Gene name | tumor suppressor 2, mitochondrial calcium regulator | |
Gene Alias | C3orf11 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | O75896 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11334 | TUSC2 | LZE2T | Human | Esophagus | ESCC | 7.07e-04 | 6.40e-01 | 0.082 |
11334 | TUSC2 | LZE4T | Human | Esophagus | ESCC | 1.98e-04 | 1.70e-01 | 0.0811 |
11334 | TUSC2 | LZE5T | Human | Esophagus | ESCC | 9.78e-05 | 3.28e-01 | 0.0514 |
11334 | TUSC2 | LZE7T | Human | Esophagus | ESCC | 1.60e-04 | 3.08e-01 | 0.0667 |
11334 | TUSC2 | LZE20T | Human | Esophagus | ESCC | 1.71e-02 | 1.13e-01 | 0.0662 |
11334 | TUSC2 | LZE22T | Human | Esophagus | ESCC | 8.31e-03 | 4.70e-01 | 0.068 |
11334 | TUSC2 | LZE24T | Human | Esophagus | ESCC | 3.29e-11 | 4.23e-01 | 0.0596 |
11334 | TUSC2 | LZE21T | Human | Esophagus | ESCC | 4.54e-05 | 2.91e-01 | 0.0655 |
11334 | TUSC2 | P1T-E | Human | Esophagus | ESCC | 3.39e-04 | 3.72e-01 | 0.0875 |
11334 | TUSC2 | P2T-E | Human | Esophagus | ESCC | 4.38e-20 | 3.25e-01 | 0.1177 |
11334 | TUSC2 | P4T-E | Human | Esophagus | ESCC | 9.74e-35 | 8.47e-01 | 0.1323 |
11334 | TUSC2 | P5T-E | Human | Esophagus | ESCC | 7.27e-27 | 4.86e-01 | 0.1327 |
11334 | TUSC2 | P8T-E | Human | Esophagus | ESCC | 2.28e-19 | 2.81e-01 | 0.0889 |
11334 | TUSC2 | P9T-E | Human | Esophagus | ESCC | 2.93e-14 | 2.41e-01 | 0.1131 |
11334 | TUSC2 | P10T-E | Human | Esophagus | ESCC | 4.33e-25 | 4.13e-01 | 0.116 |
11334 | TUSC2 | P11T-E | Human | Esophagus | ESCC | 1.65e-06 | 2.77e-01 | 0.1426 |
11334 | TUSC2 | P12T-E | Human | Esophagus | ESCC | 1.40e-16 | 3.60e-01 | 0.1122 |
11334 | TUSC2 | P15T-E | Human | Esophagus | ESCC | 4.39e-18 | 3.10e-01 | 0.1149 |
11334 | TUSC2 | P16T-E | Human | Esophagus | ESCC | 4.48e-18 | 2.93e-01 | 0.1153 |
11334 | TUSC2 | P17T-E | Human | Esophagus | ESCC | 1.94e-12 | 4.10e-01 | 0.1278 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044403111 | Esophagus | ESCC | biological process involved in symbiotic interaction | 186/8552 | 290/18723 | 1.43e-10 | 4.16e-09 | 186 |
GO:200037718 | Esophagus | ESCC | regulation of reactive oxygen species metabolic process | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:005188110 | Esophagus | ESCC | regulation of mitochondrial membrane potential | 51/8552 | 74/18723 | 4.42e-05 | 3.51e-04 | 51 |
GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
GO:005170214 | Esophagus | ESCC | biological process involved in interaction with symbiont | 57/8552 | 94/18723 | 2.46e-03 | 1.07e-02 | 57 |
GO:00300984 | Esophagus | ESCC | lymphocyte differentiation | 192/8552 | 374/18723 | 1.52e-02 | 4.93e-02 | 192 |
GO:004440312 | Liver | Cirrhotic | biological process involved in symbiotic interaction | 131/4634 | 290/18723 | 2.00e-14 | 1.84e-12 | 131 |
GO:005170211 | Liver | Cirrhotic | biological process involved in interaction with symbiont | 48/4634 | 94/18723 | 3.41e-08 | 1.14e-06 | 48 |
GO:200037712 | Liver | Cirrhotic | regulation of reactive oxygen species metabolic process | 67/4634 | 157/18723 | 6.07e-07 | 1.32e-05 | 67 |
GO:00725937 | Liver | Cirrhotic | reactive oxygen species metabolic process | 92/4634 | 239/18723 | 1.57e-06 | 3.03e-05 | 92 |
GO:00518815 | Liver | Cirrhotic | regulation of mitochondrial membrane potential | 30/4634 | 74/18723 | 1.97e-03 | 1.23e-02 | 30 |
GO:004440322 | Liver | HCC | biological process involved in symbiotic interaction | 183/7958 | 290/18723 | 9.13e-13 | 4.59e-11 | 183 |
GO:00517022 | Liver | HCC | biological process involved in interaction with symbiont | 60/7958 | 94/18723 | 2.41e-05 | 2.54e-04 | 60 |
GO:200037722 | Liver | HCC | regulation of reactive oxygen species metabolic process | 92/7958 | 157/18723 | 3.34e-05 | 3.35e-04 | 92 |
GO:005188112 | Liver | HCC | regulation of mitochondrial membrane potential | 45/7958 | 74/18723 | 1.13e-03 | 6.43e-03 | 45 |
GO:007259312 | Liver | HCC | reactive oxygen species metabolic process | 124/7958 | 239/18723 | 2.05e-03 | 1.04e-02 | 124 |
GO:004440320 | Oral cavity | OSCC | biological process involved in symbiotic interaction | 173/7305 | 290/18723 | 6.80e-13 | 3.19e-11 | 173 |
GO:200037716 | Oral cavity | OSCC | regulation of reactive oxygen species metabolic process | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TUSC2 | SNV | Missense_Mutation | c.289C>T | p.Pro97Ser | p.P97S | O75896 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TUSC2 | SNV | Missense_Mutation | rs782369955 | c.226N>T | p.Arg76Trp | p.R76W | O75896 | protein_coding | tolerated(0.07) | possibly_damaging(0.895) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11334 | TUSC2 | NA | CNVN-202 | |||
11334 | TUSC2 | NA | Fus-1 tumor suppressor gene therapy - nanoparticle formulation |
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