![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TUFT1 |
Gene summary for TUFT1 |
![]() |
Gene information | Species | Human | Gene symbol | TUFT1 | Gene ID | 7286 |
Gene name | tuftelin 1 | |
Gene Alias | TUFT1 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | Q9NNX1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7286 | TUFT1 | LZE4T | Human | Esophagus | ESCC | 2.53e-13 | 4.32e-01 | 0.0811 |
7286 | TUFT1 | LZE7T | Human | Esophagus | ESCC | 3.66e-09 | 7.86e-01 | 0.0667 |
7286 | TUFT1 | LZE20T | Human | Esophagus | ESCC | 9.76e-06 | 1.47e-01 | 0.0662 |
7286 | TUFT1 | LZE22T | Human | Esophagus | ESCC | 1.97e-03 | 7.73e-01 | 0.068 |
7286 | TUFT1 | LZE24T | Human | Esophagus | ESCC | 5.62e-09 | 3.26e-01 | 0.0596 |
7286 | TUFT1 | LZE21T | Human | Esophagus | ESCC | 5.71e-14 | 5.39e-01 | 0.0655 |
7286 | TUFT1 | P1T-E | Human | Esophagus | ESCC | 2.92e-12 | 6.80e-01 | 0.0875 |
7286 | TUFT1 | P2T-E | Human | Esophagus | ESCC | 3.51e-22 | 4.44e-01 | 0.1177 |
7286 | TUFT1 | P4T-E | Human | Esophagus | ESCC | 2.79e-25 | 3.77e-01 | 0.1323 |
7286 | TUFT1 | P5T-E | Human | Esophagus | ESCC | 1.15e-31 | 5.94e-01 | 0.1327 |
7286 | TUFT1 | P8T-E | Human | Esophagus | ESCC | 6.37e-11 | 1.54e-01 | 0.0889 |
7286 | TUFT1 | P9T-E | Human | Esophagus | ESCC | 2.32e-30 | 9.29e-01 | 0.1131 |
7286 | TUFT1 | P10T-E | Human | Esophagus | ESCC | 5.92e-31 | 5.88e-01 | 0.116 |
7286 | TUFT1 | P11T-E | Human | Esophagus | ESCC | 2.33e-04 | 5.25e-01 | 0.1426 |
7286 | TUFT1 | P12T-E | Human | Esophagus | ESCC | 1.74e-22 | 5.20e-01 | 0.1122 |
7286 | TUFT1 | P15T-E | Human | Esophagus | ESCC | 1.41e-31 | 8.75e-01 | 0.1149 |
7286 | TUFT1 | P16T-E | Human | Esophagus | ESCC | 4.00e-10 | 6.80e-02 | 0.1153 |
7286 | TUFT1 | P20T-E | Human | Esophagus | ESCC | 3.41e-06 | 3.76e-01 | 0.1124 |
7286 | TUFT1 | P21T-E | Human | Esophagus | ESCC | 3.60e-16 | 3.65e-01 | 0.1617 |
7286 | TUFT1 | P22T-E | Human | Esophagus | ESCC | 3.73e-21 | 4.70e-01 | 0.1236 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
GO:000150315 | Oral cavity | LP | ossification | 123/4623 | 408/18723 | 6.55e-03 | 3.84e-02 | 123 |
GO:000150323 | Skin | cSCC | ossification | 137/4864 | 408/18723 | 3.39e-04 | 2.68e-03 | 137 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TUFT1 | SNV | Missense_Mutation | rs751924952 | c.854N>A | p.Arg285Gln | p.R285Q | Q9NNX1 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A7-A6VY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
TUFT1 | deletion | In_Frame_Del | novel | c.171_173delNNN | p.His57_Ser58delinsGln | p.H57_S58delinsQ | Q9NNX1 | protein_coding | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
TUFT1 | insertion | Nonsense_Mutation | novel | c.215_216insATAGTTTAGTTCAGGAAGAATATGCTAGTCT | p.Asp72GlufsTer2 | p.D72Efs*2 | Q9NNX1 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TUFT1 | SNV | Missense_Mutation | c.127N>A | p.Ala43Thr | p.A43T | Q9NNX1 | protein_coding | tolerated(0.48) | possibly_damaging(0.542) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
TUFT1 | SNV | Missense_Mutation | c.246N>C | p.Leu82Phe | p.L82F | Q9NNX1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TUFT1 | SNV | Missense_Mutation | c.246N>C | p.Leu82Phe | p.L82F | Q9NNX1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TUFT1 | SNV | Missense_Mutation | rs754728864 | c.961N>A | p.Ala321Thr | p.A321T | Q9NNX1 | protein_coding | tolerated(0.79) | benign(0.006) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TUFT1 | SNV | Missense_Mutation | rs368431369 | c.1157G>A | p.Arg386Gln | p.R386Q | Q9NNX1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TUFT1 | SNV | Missense_Mutation | rs865962681 | c.731N>G | p.Gln244Arg | p.Q244R | Q9NNX1 | protein_coding | tolerated(0.3) | benign(0.261) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TUFT1 | SNV | Missense_Mutation | rs754728864 | c.961G>A | p.Ala321Thr | p.A321T | Q9NNX1 | protein_coding | tolerated(0.79) | benign(0.006) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |