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Gene: TUBE1 |
Gene summary for TUBE1 |
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Gene information | Species | Human | Gene symbol | TUBE1 | Gene ID | 51175 |
Gene name | tubulin epsilon 1 | |
Gene Alias | TUBE | |
Cytomap | 6q21 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q9UJT0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51175 | TUBE1 | LZE24T | Human | Esophagus | ESCC | 1.95e-07 | 1.73e-01 | 0.0596 |
51175 | TUBE1 | P2T-E | Human | Esophagus | ESCC | 3.23e-06 | 1.26e-01 | 0.1177 |
51175 | TUBE1 | P4T-E | Human | Esophagus | ESCC | 7.81e-15 | 2.91e-01 | 0.1323 |
51175 | TUBE1 | P5T-E | Human | Esophagus | ESCC | 1.24e-11 | 7.03e-02 | 0.1327 |
51175 | TUBE1 | P8T-E | Human | Esophagus | ESCC | 8.88e-14 | 1.74e-01 | 0.0889 |
51175 | TUBE1 | P9T-E | Human | Esophagus | ESCC | 3.23e-02 | 7.61e-02 | 0.1131 |
51175 | TUBE1 | P10T-E | Human | Esophagus | ESCC | 9.22e-10 | 1.28e-01 | 0.116 |
51175 | TUBE1 | P11T-E | Human | Esophagus | ESCC | 2.67e-05 | 2.14e-01 | 0.1426 |
51175 | TUBE1 | P12T-E | Human | Esophagus | ESCC | 2.92e-14 | 1.95e-01 | 0.1122 |
51175 | TUBE1 | P15T-E | Human | Esophagus | ESCC | 1.82e-07 | 1.37e-01 | 0.1149 |
51175 | TUBE1 | P16T-E | Human | Esophagus | ESCC | 2.26e-15 | 2.50e-01 | 0.1153 |
51175 | TUBE1 | P21T-E | Human | Esophagus | ESCC | 2.51e-18 | 2.35e-01 | 0.1617 |
51175 | TUBE1 | P22T-E | Human | Esophagus | ESCC | 2.84e-07 | 5.73e-03 | 0.1236 |
51175 | TUBE1 | P23T-E | Human | Esophagus | ESCC | 6.72e-07 | 2.64e-01 | 0.108 |
51175 | TUBE1 | P24T-E | Human | Esophagus | ESCC | 1.94e-08 | 5.32e-02 | 0.1287 |
51175 | TUBE1 | P26T-E | Human | Esophagus | ESCC | 1.04e-11 | 2.14e-01 | 0.1276 |
51175 | TUBE1 | P27T-E | Human | Esophagus | ESCC | 2.75e-19 | 1.22e-01 | 0.1055 |
51175 | TUBE1 | P28T-E | Human | Esophagus | ESCC | 1.45e-06 | 1.68e-01 | 0.1149 |
51175 | TUBE1 | P30T-E | Human | Esophagus | ESCC | 4.56e-08 | 2.40e-01 | 0.137 |
51175 | TUBE1 | P31T-E | Human | Esophagus | ESCC | 3.81e-13 | 1.30e-01 | 0.1251 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070982 | Esophagus | ESCC | centrosome cycle | 85/8552 | 130/18723 | 4.41e-06 | 4.69e-05 | 85 |
GO:00310233 | Esophagus | ESCC | microtubule organizing center organization | 92/8552 | 143/18723 | 5.04e-06 | 5.31e-05 | 92 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TUBE1 | SNV | Missense_Mutation | c.713N>T | p.Ser238Ile | p.S238I | Q9UJT0 | protein_coding | deleterious(0.04) | possibly_damaging(0.837) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TUBE1 | SNV | Missense_Mutation | c.931N>T | p.Asp311Tyr | p.D311Y | Q9UJT0 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
TUBE1 | SNV | Missense_Mutation | novel | c.778A>G | p.Asn260Asp | p.N260D | Q9UJT0 | protein_coding | tolerated(0.09) | benign(0.082) | TCGA-E2-A15G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TUBE1 | deletion | Frame_Shift_Del | c.746delN | p.Lys249SerfsTer10 | p.K249Sfs*10 | Q9UJT0 | protein_coding | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |||
TUBE1 | deletion | Frame_Shift_Del | c.1268delN | p.Lys423ArgfsTer49 | p.K423Rfs*49 | Q9UJT0 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
TUBE1 | SNV | Missense_Mutation | novel | c.779A>G | p.Asn260Ser | p.N260S | Q9UJT0 | protein_coding | tolerated(0.23) | benign(0.028) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TUBE1 | SNV | Missense_Mutation | novel | c.545N>G | p.Glu182Gly | p.E182G | Q9UJT0 | protein_coding | deleterious(0.01) | possibly_damaging(0.491) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TUBE1 | SNV | Missense_Mutation | rs782360031 | c.290A>G | p.Gln97Arg | p.Q97R | Q9UJT0 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TUBE1 | SNV | Missense_Mutation | c.1253G>A | p.Arg418Lys | p.R418K | Q9UJT0 | protein_coding | tolerated(1) | benign(0) | TCGA-A6-2677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD | |
TUBE1 | SNV | Missense_Mutation | c.190N>C | p.Ile64Leu | p.I64L | Q9UJT0 | protein_coding | deleterious(0.04) | benign(0.147) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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