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Gene: TTYH3 |
Gene summary for TTYH3 |
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Gene information | Species | Human | Gene symbol | TTYH3 | Gene ID | 80727 |
Gene name | tweety family member 3 | |
Gene Alias | TTYH3 | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R816 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80727 | TTYH3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.73e-06 | 2.07e-01 | 0.0155 |
80727 | TTYH3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.63e-04 | 3.83e-01 | -0.1808 |
80727 | TTYH3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.99e-09 | 5.61e-01 | -0.0811 |
80727 | TTYH3 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.73e-13 | 4.46e-01 | -0.1464 |
80727 | TTYH3 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.34e-02 | 2.22e-01 | -0.1001 |
80727 | TTYH3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.32e-24 | 8.36e-01 | -0.059 |
80727 | TTYH3 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.91e-03 | 3.03e-01 | -0.0842 |
80727 | TTYH3 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.93e-27 | 6.81e-01 | 0.096 |
80727 | TTYH3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.94e-02 | 2.36e-01 | 0.0528 |
80727 | TTYH3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.11e-04 | 4.27e-01 | 0.0131 |
80727 | TTYH3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.43e-07 | 4.36e-01 | 0.0338 |
80727 | TTYH3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.05e-31 | 7.19e-01 | 0.0674 |
80727 | TTYH3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.28e-03 | 5.06e-01 | 0.0112 |
80727 | TTYH3 | HTA11_11156_2000001011 | Human | Colorectum | AD | 7.22e-08 | 9.03e-01 | 0.0397 |
80727 | TTYH3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.47e-08 | 3.98e-01 | 0.0588 |
80727 | TTYH3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.04e-11 | 3.56e-01 | 0.294 |
80727 | TTYH3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.16e-05 | 6.51e-01 | 0.3487 |
80727 | TTYH3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.01e-05 | 3.37e-01 | 0.281 |
80727 | TTYH3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.26e-22 | 7.20e-01 | 0.3859 |
80727 | TTYH3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.64e-09 | 5.35e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTYH3 | deletion | Frame_Shift_Del | novel | c.325delN | p.Glu110ArgfsTer34 | p.E110Rfs*34 | Q9C0H2 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TTYH3 | SNV | Missense_Mutation | novel | c.1034N>T | p.Arg345Leu | p.R345L | Q9C0H2 | protein_coding | tolerated(0.14) | benign(0.299) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TTYH3 | SNV | Missense_Mutation | c.820N>T | p.Pro274Ser | p.P274S | Q9C0H2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTYH3 | SNV | Missense_Mutation | rs769571456 | c.910N>A | p.Ala304Thr | p.A304T | Q9C0H2 | protein_coding | tolerated(0.38) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TTYH3 | SNV | Missense_Mutation | c.1319N>A | p.Arg440His | p.R440H | Q9C0H2 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTYH3 | SNV | Missense_Mutation | novel | c.1306N>A | p.Asp436Asn | p.D436N | Q9C0H2 | protein_coding | tolerated(0.35) | possibly_damaging(0.559) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TTYH3 | SNV | Missense_Mutation | c.1051A>G | p.Asn351Asp | p.N351D | Q9C0H2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTYH3 | SNV | Missense_Mutation | c.1481G>A | p.Arg494His | p.R494H | Q9C0H2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TTYH3 | SNV | Missense_Mutation | c.509N>A | p.Arg170Lys | p.R170K | Q9C0H2 | protein_coding | tolerated(1) | benign(0.007) | TCGA-DC-4749-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TTYH3 | SNV | Missense_Mutation | rs763565617 | c.214N>T | p.Arg72Trp | p.R72W | Q9C0H2 | protein_coding | deleterious(0) | possibly_damaging(0.888) | TCGA-EI-6512-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folfox | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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