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Gene: TTTY14 |
Gene summary for TTTY14 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TTTY14 | Gene ID | 83869 |
| Gene name | testis-specific transcript, Y-linked 14 | |
| Gene Alias | CYorf14 | |
| Cytomap | Yq11.222 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 83869 | TTTY14 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.33e-15 | -5.95e-01 | 0.0155 |
| 83869 | TTTY14 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.95e-06 | 9.91e-01 | -0.1088 |
| 83869 | TTTY14 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.01e-14 | 1.02e+00 | -0.1954 |
| 83869 | TTTY14 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.71e-03 | 5.06e-01 | -0.1001 |
| 83869 | TTTY14 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.04e-06 | 9.00e-01 | -0.059 |
| 83869 | TTTY14 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.40e-03 | -7.22e-01 | 0.0528 |
| 83869 | TTTY14 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.00e-03 | 7.70e-01 | 0.0131 |
| 83869 | TTTY14 | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.84e-03 | 7.23e-01 | -0.0177 |
| 83869 | TTTY14 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.14e-02 | -5.10e-01 | 0.0338 |
| 83869 | TTTY14 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.63e-24 | 1.90e+00 | 0.281 |
| 83869 | TTTY14 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.56e-24 | -6.93e-01 | 0.3005 |
| 83869 | TTTY14 | F007 | Human | Colorectum | FAP | 3.25e-22 | -9.06e-01 | 0.1176 |
| 83869 | TTTY14 | A002-C-010 | Human | Colorectum | FAP | 5.68e-40 | -8.60e-01 | 0.242 |
| 83869 | TTTY14 | A001-C-207 | Human | Colorectum | FAP | 5.24e-07 | -5.22e-01 | 0.1278 |
| 83869 | TTTY14 | A015-C-203 | Human | Colorectum | FAP | 6.62e-26 | -5.89e-01 | -0.1294 |
| 83869 | TTTY14 | A015-C-204 | Human | Colorectum | FAP | 3.25e-11 | -6.52e-01 | -0.0228 |
| 83869 | TTTY14 | A014-C-040 | Human | Colorectum | FAP | 6.13e-09 | -8.61e-01 | -0.1184 |
| 83869 | TTTY14 | A002-C-201 | Human | Colorectum | FAP | 1.38e-17 | -6.38e-01 | 0.0324 |
| 83869 | TTTY14 | A002-C-203 | Human | Colorectum | FAP | 5.85e-23 | -7.59e-01 | 0.2786 |
| 83869 | TTTY14 | A001-C-108 | Human | Colorectum | FAP | 6.19e-06 | -2.75e-01 | -0.0272 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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