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Gene: TTPAL |
Gene summary for TTPAL |
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Gene information | Species | Human | Gene symbol | TTPAL | Gene ID | 79183 |
Gene name | alpha tocopherol transfer protein like | |
Gene Alias | C20orf121 | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B2RA57 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79183 | TTPAL | LZE4T | Human | Esophagus | ESCC | 3.44e-07 | 1.10e-01 | 0.0811 |
79183 | TTPAL | LZE24T | Human | Esophagus | ESCC | 6.94e-05 | 3.85e-02 | 0.0596 |
79183 | TTPAL | P2T-E | Human | Esophagus | ESCC | 1.19e-10 | 6.39e-02 | 0.1177 |
79183 | TTPAL | P4T-E | Human | Esophagus | ESCC | 4.23e-12 | 1.01e-01 | 0.1323 |
79183 | TTPAL | P5T-E | Human | Esophagus | ESCC | 2.02e-04 | 5.08e-02 | 0.1327 |
79183 | TTPAL | P8T-E | Human | Esophagus | ESCC | 3.04e-04 | 5.73e-02 | 0.0889 |
79183 | TTPAL | P10T-E | Human | Esophagus | ESCC | 8.42e-12 | 1.53e-01 | 0.116 |
79183 | TTPAL | P11T-E | Human | Esophagus | ESCC | 2.62e-03 | 9.51e-02 | 0.1426 |
79183 | TTPAL | P12T-E | Human | Esophagus | ESCC | 1.45e-12 | 8.85e-02 | 0.1122 |
79183 | TTPAL | P15T-E | Human | Esophagus | ESCC | 1.85e-18 | 1.81e-01 | 0.1149 |
79183 | TTPAL | P16T-E | Human | Esophagus | ESCC | 1.16e-07 | 1.31e-01 | 0.1153 |
79183 | TTPAL | P17T-E | Human | Esophagus | ESCC | 1.04e-07 | 2.76e-01 | 0.1278 |
79183 | TTPAL | P20T-E | Human | Esophagus | ESCC | 9.32e-05 | 7.65e-02 | 0.1124 |
79183 | TTPAL | P21T-E | Human | Esophagus | ESCC | 4.79e-14 | 3.22e-01 | 0.1617 |
79183 | TTPAL | P22T-E | Human | Esophagus | ESCC | 1.40e-10 | 7.87e-02 | 0.1236 |
79183 | TTPAL | P23T-E | Human | Esophagus | ESCC | 1.98e-09 | 1.10e-01 | 0.108 |
79183 | TTPAL | P24T-E | Human | Esophagus | ESCC | 1.19e-10 | 2.26e-01 | 0.1287 |
79183 | TTPAL | P26T-E | Human | Esophagus | ESCC | 6.36e-14 | 2.35e-01 | 0.1276 |
79183 | TTPAL | P28T-E | Human | Esophagus | ESCC | 3.50e-12 | 1.19e-01 | 0.1149 |
79183 | TTPAL | P31T-E | Human | Esophagus | ESCC | 2.22e-06 | 1.36e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTPAL | SNV | Missense_Mutation | novel | c.909A>C | p.Gln303His | p.Q303H | Q9BTX7 | protein_coding | tolerated(0.44) | benign(0) | TCGA-AR-A1AY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Doxorubicin | SD |
TTPAL | SNV | Missense_Mutation | c.490G>A | p.Ala164Thr | p.A164T | Q9BTX7 | protein_coding | tolerated(0.07) | possibly_damaging(0.473) | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
TTPAL | insertion | In_Frame_Ins | novel | c.721_722insGTCTCGAACTCCTGACCTCAAGTGATCCGCCCACCTCGG | p.Pro241delinsArgLeuGluLeuLeuThrSerSerAspProProThrSerAla | p.P241delinsRLELLTSSDPPTSA | Q9BTX7 | protein_coding | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | ||
TTPAL | insertion | Frame_Shift_Ins | novel | c.665_666insTCTGAACAGGAATGCAGTTAAGGAAACTCACTTGATTATGCTT | p.Val223LeufsTer20 | p.V223Lfs*20 | Q9BTX7 | protein_coding | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TTPAL | insertion | Frame_Shift_Ins | novel | c.740_741insGACACGATTTTGGCTCACTGCAACCTCCACCTCC | p.Ile247MetfsTer22 | p.I247Mfs*22 | Q9BTX7 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TTPAL | deletion | Frame_Shift_Del | novel | c.146delN | p.Lys50SerfsTer23 | p.K50Sfs*23 | Q9BTX7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TTPAL | deletion | Frame_Shift_Del | c.197delN | p.Lys67ArgfsTer6 | p.K67Rfs*6 | Q9BTX7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
TTPAL | SNV | Missense_Mutation | novel | c.1006N>C | p.Ser336Pro | p.S336P | Q9BTX7 | protein_coding | tolerated_low_confidence(0.19) | benign(0.006) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TTPAL | SNV | Missense_Mutation | c.277N>A | p.Asp93Asn | p.D93N | Q9BTX7 | protein_coding | tolerated(0.17) | probably_damaging(0.991) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TTPAL | SNV | Missense_Mutation | c.712A>C | p.Ile238Leu | p.I238L | Q9BTX7 | protein_coding | tolerated(0.14) | possibly_damaging(0.56) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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