Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TTLL5

Gene summary for TTLL5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TTLL5

Gene ID

23093

Gene nametubulin tyrosine ligase like 5
Gene AliasCORD19
Cytomap14q24.3
Gene Typeprotein-coding
GO ID

GO:0000226

UniProtAcc

Q6EMB2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23093TTLL5CCI_1HumanCervixCC5.12e-099.34e-010.528
23093TTLL5CCI_2HumanCervixCC2.81e-067.17e-010.5249
23093TTLL5CCI_3HumanCervixCC1.98e-066.27e-010.516
23093TTLL5HTA11_2487_2000001011HumanColorectumSER4.96e-02-3.04e-01-0.1808
23093TTLL5HTA11_7696_3000711011HumanColorectumAD5.12e-03-2.59e-010.0674
23093TTLL5HTA11_99999971662_82457HumanColorectumMSS5.30e-05-3.62e-010.3859
23093TTLL5HTA11_99999974143_84620HumanColorectumMSS2.17e-09-4.27e-010.3005
23093TTLL5A015-C-203HumanColorectumFAP2.46e-23-4.17e-01-0.1294
23093TTLL5A015-C-204HumanColorectumFAP3.98e-07-4.59e-01-0.0228
23093TTLL5A002-C-201HumanColorectumFAP1.99e-10-3.07e-010.0324
23093TTLL5A001-C-119HumanColorectumFAP2.46e-03-3.36e-01-0.1557
23093TTLL5A001-C-108HumanColorectumFAP3.71e-09-2.83e-01-0.0272
23093TTLL5A002-C-205HumanColorectumFAP7.58e-16-3.51e-01-0.1236
23093TTLL5A015-C-005HumanColorectumFAP2.67e-03-2.57e-01-0.0336
23093TTLL5A015-C-006HumanColorectumFAP1.91e-12-3.29e-01-0.0994
23093TTLL5A015-C-106HumanColorectumFAP6.25e-09-3.04e-01-0.0511
23093TTLL5A002-C-114HumanColorectumFAP5.41e-16-4.53e-01-0.1561
23093TTLL5A015-C-104HumanColorectumFAP1.02e-23-4.49e-01-0.1899
23093TTLL5A001-C-014HumanColorectumFAP2.52e-06-2.62e-010.0135
23093TTLL5A002-C-016HumanColorectumFAP6.48e-16-3.13e-010.0521
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0150063CervixCCvisual system development63/2311375/187236.58e-033.65e-0263
GO:0001654CervixCCeye development62/2311371/187237.83e-034.13e-0262
GO:0048880CervixCCsensory system development63/2311381/187239.29e-034.66e-0263
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TTLL5SNVMissense_Mutationc.211N>Gp.Arg71Glyp.R71GQ6EMB2protein_codingdeleterious(0)possibly_damaging(0.903)TCGA-A2-A0EQ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
TTLL5SNVMissense_Mutationrs374783896c.568N>Ap.Val190Ilep.V190IQ6EMB2protein_codingtolerated(0.91)benign(0.188)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TTLL5SNVMissense_Mutationnovelc.2430N>Tp.Lys810Asnp.K810NQ6EMB2protein_codingdeleterious(0)probably_damaging(0.994)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TTLL5SNVMissense_Mutationrs746432496c.1033N>Gp.Ser345Glyp.S345GQ6EMB2protein_codingdeleterious(0)possibly_damaging(0.796)TCGA-AR-A24R-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
TTLL5SNVMissense_Mutationc.2747C>Tp.Ser916Phep.S916FQ6EMB2protein_codingdeleterious(0.02)benign(0.224)TCGA-B6-A0WZ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
TTLL5SNVMissense_Mutationc.1723G>Ap.Ala575Thrp.A575TQ6EMB2protein_codingtolerated(0.69)benign(0.007)TCGA-BH-A0DS-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycyclophosphamideSD
TTLL5insertionIn_Frame_Insnovelc.1604_1605insTATACTp.Ala535_Lys536insIleLeup.A535_K536insILQ6EMB2protein_codingTCGA-A8-A07G-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilCR
TTLL5insertionNonsense_Mutationnovelc.1606_1607insGAGACTGAAAACTCCCAGAGGAGTTAGGATGp.Lys536ArgfsTer3p.K536Rfs*3Q6EMB2protein_codingTCGA-A8-A07G-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilCR
TTLL5insertionFrame_Shift_Insnovelc.554_555insTTCTTTGp.Arg186SerfsTer29p.R186Sfs*29Q6EMB2protein_codingTCGA-AN-A03X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TTLL5insertionNonsense_Mutationnovelc.555_556insGGGTAGAGATATCGCATATCTTTGGATGTTp.Ser185_Arg186insGlyTerArgTyrArgIleSerLeuAspValp.S185_R186insG*RYRISLDVQ6EMB2protein_codingTCGA-AN-A03X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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