Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TTC8

Gene summary for TTC8

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TTC8

Gene ID

123016

Gene nametetratricopeptide repeat domain 8
Gene AliasBBS8
Cytomap14q31.3
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

A0A0C4DGX9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
123016TTC8LZE4THumanEsophagusESCC5.98e-122.60e-010.0811
123016TTC8LZE5THumanEsophagusESCC1.39e-042.97e-010.0514
123016TTC8LZE8THumanEsophagusESCC1.37e-038.23e-020.067
123016TTC8LZE20THumanEsophagusESCC6.83e-041.25e-010.0662
123016TTC8LZE24THumanEsophagusESCC2.78e-051.53e-010.0596
123016TTC8P1T-EHumanEsophagusESCC4.65e-021.26e-010.0875
123016TTC8P2T-EHumanEsophagusESCC1.37e-223.53e-010.1177
123016TTC8P4T-EHumanEsophagusESCC1.68e-141.24e-010.1323
123016TTC8P5T-EHumanEsophagusESCC1.02e-061.07e-010.1327
123016TTC8P8T-EHumanEsophagusESCC2.97e-173.26e-010.0889
123016TTC8P9T-EHumanEsophagusESCC5.61e-068.28e-020.1131
123016TTC8P10T-EHumanEsophagusESCC5.32e-183.13e-010.116
123016TTC8P11T-EHumanEsophagusESCC1.48e-082.69e-010.1426
123016TTC8P12T-EHumanEsophagusESCC1.24e-173.37e-010.1122
123016TTC8P15T-EHumanEsophagusESCC1.15e-223.86e-010.1149
123016TTC8P16T-EHumanEsophagusESCC5.66e-293.49e-010.1153
123016TTC8P17T-EHumanEsophagusESCC5.12e-072.45e-010.1278
123016TTC8P20T-EHumanEsophagusESCC2.40e-071.57e-010.1124
123016TTC8P21T-EHumanEsophagusESCC3.90e-222.35e-010.1617
123016TTC8P22T-EHumanEsophagusESCC2.40e-183.11e-010.1236
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0072659110EsophagusESCCprotein localization to plasma membrane193/8552284/187231.95e-141.03e-12193
GO:199077819EsophagusESCCprotein localization to cell periphery217/8552333/187234.08e-131.88e-11217
GO:1902903111EsophagusESCCregulation of supramolecular fiber organization237/8552383/187239.06e-112.75e-09237
GO:000716320EsophagusESCCestablishment or maintenance of cell polarity143/8552218/187232.05e-094.65e-08143
GO:000701527EsophagusESCCactin filament organization259/8552442/187232.37e-084.50e-07259
GO:003001018EsophagusESCCestablishment of cell polarity96/8552143/187231.69e-072.67e-0696
GO:0032970111EsophagusESCCregulation of actin filament-based process231/8552397/187232.91e-074.20e-06231
GO:0032956111EsophagusESCCregulation of actin cytoskeleton organization210/8552358/187234.40e-076.00e-06210
GO:011005327EsophagusESCCregulation of actin filament organization166/8552278/187231.54e-061.85e-05166
GO:005101727EsophagusESCCactin filament bundle assembly100/8552157/187233.87e-064.17e-05100
GO:006157227EsophagusESCCactin filament bundle organization101/8552161/187239.22e-068.82e-05101
GO:00017387EsophagusESCCmorphogenesis of a polarized epithelium63/855294/187232.34e-052.00e-0463
GO:00454449EsophagusESCCfat cell differentiation135/8552229/187233.38e-052.78e-04135
GO:009016216EsophagusESCCestablishment of epithelial cell polarity25/855231/187237.13e-055.38e-0425
GO:00308595EsophagusESCCpolarized epithelial cell differentiation20/855224/187231.69e-041.11e-0320
GO:00611625EsophagusESCCestablishment of monopolar cell polarity20/855224/187231.69e-041.11e-0320
GO:0051346110EsophagusESCCnegative regulation of hydrolase activity208/8552379/187231.76e-041.14e-03208
GO:003003820EsophagusESCCcontractile actin filament bundle assembly67/8552106/187232.03e-041.28e-0367
GO:004314920EsophagusESCCstress fiber assembly67/8552106/187232.03e-041.28e-0367
GO:006156415EsophagusESCCaxon development251/8552467/187232.41e-041.49e-03251
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TTC8SNVMissense_Mutationnovelc.797N>Tp.Ser266Leup.S266Lprotein_codingdeleterious(0)possibly_damaging(0.749)TCGA-AN-A0AS-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
TTC8SNVMissense_Mutationc.1494N>Cp.Gln498Hisp.Q498Hprotein_codingtolerated(0.14)benign(0.25)TCGA-C5-A1BQ-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinCR
TTC8SNVMissense_Mutationrs755412340c.1099N>Tp.Arg367Trpp.R367Wprotein_codingdeleterious(0)probably_damaging(0.988)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
TTC8SNVMissense_Mutationc.492T>Ap.Phe164Leup.F164Lprotein_codingdeleterious(0)possibly_damaging(0.835)TCGA-AD-6901-01Colorectumcolon adenocarcinomaMale>=65I/IIChemotherapyxelodaPD
TTC8SNVMissense_Mutationnovelc.1211C>Ap.Ser404Tyrp.S404Yprotein_codingtolerated(0.42)benign(0.031)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
TTC8SNVMissense_Mutationrs760040510c.773N>Ap.Arg258Hisp.R258Hprotein_codingdeleterious(0)probably_damaging(0.981)TCGA-G4-6588-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
TTC8insertionFrame_Shift_Insnovelc.805_806insGGATGAATAGp.Lys269ArgfsTer38p.K269Rfs*38protein_codingTCGA-AM-5820-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
TTC8SNVMissense_Mutationc.452N>Cp.Leu151Prop.L151Pprotein_codingdeleterious(0.02)probably_damaging(0.951)TCGA-A5-A0GB-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
TTC8SNVMissense_Mutationc.168A>Cp.Glu56Aspp.E56Dprotein_codingtolerated(0.74)benign(0.02)TCGA-AP-A056-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
TTC8SNVMissense_Mutationnovelc.1022A>Gp.His341Argp.H341Rprotein_codingdeleterious(0.01)benign(0.355)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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