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Gene: TTC7A |
Gene summary for TTC7A |
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Gene information | Species | Human | Gene symbol | TTC7A | Gene ID | 57217 |
Gene name | tetratricopeptide repeat domain 7A | |
Gene Alias | GIDID | |
Cytomap | 2p21 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9ULT0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57217 | TTC7A | CCI_1 | Human | Cervix | CC | 3.65e-06 | 6.64e-01 | 0.528 |
57217 | TTC7A | CCI_2 | Human | Cervix | CC | 2.45e-05 | 7.58e-01 | 0.5249 |
57217 | TTC7A | CCI_3 | Human | Cervix | CC | 7.00e-06 | 6.29e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00550726 | Cervix | CC | iron ion homeostasis | 19/2311 | 85/18723 | 6.88e-03 | 3.74e-02 | 19 |
GO:00550768 | Cervix | CC | transition metal ion homeostasis | 27/2311 | 138/18723 | 9.89e-03 | 4.85e-02 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC7A | SNV | Missense_Mutation | novel | c.1988N>A | p.Gly663Glu | p.G663E | Q9ULT0 | protein_coding | deleterious(0.04) | benign(0) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TTC7A | SNV | Missense_Mutation | novel | c.2024N>T | p.Gly675Val | p.G675V | Q9ULT0 | protein_coding | tolerated(0.39) | benign(0.012) | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
TTC7A | SNV | Missense_Mutation | rs765995326 | c.2099N>A | p.Arg700Gln | p.R700Q | Q9ULT0 | protein_coding | tolerated(0.1) | possibly_damaging(0.559) | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TTC7A | SNV | Missense_Mutation | c.571G>A | p.Glu191Lys | p.E191K | Q9ULT0 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TTC7A | SNV | Missense_Mutation | rs758259662 | c.2113N>A | p.Ala705Thr | p.A705T | Q9ULT0 | protein_coding | deleterious(0.02) | probably_damaging(0.943) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC7A | SNV | Missense_Mutation | rs145006355 | c.1684N>T | p.Arg562Cys | p.R562C | Q9ULT0 | protein_coding | tolerated(0.12) | benign(0) | TCGA-AN-A0AM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTC7A | SNV | Missense_Mutation | rs148317608 | c.1435G>A | p.Gly479Arg | p.G479R | Q9ULT0 | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-AO-A1KT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
TTC7A | SNV | Missense_Mutation | rs544316606 | c.562N>T | p.Arg188Cys | p.R188C | Q9ULT0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AR-A24Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TTC7A | SNV | Missense_Mutation | rs541501653 | c.413N>A | p.Arg138Gln | p.R138Q | Q9ULT0 | protein_coding | tolerated(0.26) | benign(0.375) | TCGA-E9-A226-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
TTC7A | insertion | Frame_Shift_Ins | novel | c.1428_1429insAGCCTCGGAGAGGA | p.Gly483SerfsTer29 | p.G483Sfs*29 | Q9ULT0 | protein_coding | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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