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Gene: TTC4 |
Gene summary for TTC4 |
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Gene information | Species | Human | Gene symbol | TTC4 | Gene ID | 7268 |
Gene name | tetratricopeptide repeat domain 4 | |
Gene Alias | CNS1 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | O95801 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7268 | TTC4 | LZE4T | Human | Esophagus | ESCC | 1.20e-04 | 1.59e-01 | 0.0811 |
7268 | TTC4 | LZE7T | Human | Esophagus | ESCC | 2.07e-09 | 2.98e-01 | 0.0667 |
7268 | TTC4 | LZE8T | Human | Esophagus | ESCC | 1.65e-04 | 1.53e-01 | 0.067 |
7268 | TTC4 | LZE20T | Human | Esophagus | ESCC | 7.18e-07 | 2.79e-01 | 0.0662 |
7268 | TTC4 | LZE24T | Human | Esophagus | ESCC | 1.28e-07 | 2.02e-01 | 0.0596 |
7268 | TTC4 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 1.79e-01 | 0.0655 |
7268 | TTC4 | LZE6T | Human | Esophagus | ESCC | 9.61e-05 | 1.85e-01 | 0.0845 |
7268 | TTC4 | P1T-E | Human | Esophagus | ESCC | 1.09e-04 | 2.19e-01 | 0.0875 |
7268 | TTC4 | P2T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.79e-01 | 0.1177 |
7268 | TTC4 | P4T-E | Human | Esophagus | ESCC | 2.81e-07 | 2.00e-01 | 0.1323 |
7268 | TTC4 | P5T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.82e-01 | 0.1327 |
7268 | TTC4 | P8T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.02e-01 | 0.0889 |
7268 | TTC4 | P9T-E | Human | Esophagus | ESCC | 1.45e-04 | 1.46e-01 | 0.1131 |
7268 | TTC4 | P10T-E | Human | Esophagus | ESCC | 2.56e-16 | 2.86e-01 | 0.116 |
7268 | TTC4 | P11T-E | Human | Esophagus | ESCC | 1.20e-09 | 3.33e-01 | 0.1426 |
7268 | TTC4 | P12T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.30e-01 | 0.1122 |
7268 | TTC4 | P15T-E | Human | Esophagus | ESCC | 5.63e-18 | 3.33e-01 | 0.1149 |
7268 | TTC4 | P16T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.57e-01 | 0.1153 |
7268 | TTC4 | P17T-E | Human | Esophagus | ESCC | 9.15e-12 | 3.84e-01 | 0.1278 |
7268 | TTC4 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.42e-01 | 0.1662 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC4 | SNV | Missense_Mutation | c.639G>C | p.Lys213Asn | p.K213N | O95801 | protein_coding | deleterious(0.01) | possibly_damaging(0.859) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TTC4 | SNV | Missense_Mutation | c.668T>C | p.Leu223Pro | p.L223P | O95801 | protein_coding | deleterious(0) | benign(0.024) | TCGA-A8-A09T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
TTC4 | SNV | Missense_Mutation | novel | c.448N>A | p.His150Asn | p.H150N | O95801 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC4 | SNV | Missense_Mutation | c.572G>C | p.Arg191Thr | p.R191T | O95801 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-B6-A0RU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TTC4 | SNV | Missense_Mutation | c.118N>C | p.Glu40Gln | p.E40Q | O95801 | protein_coding | deleterious(0.02) | benign(0.054) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
TTC4 | insertion | Nonsense_Mutation | novel | c.553_554insTATTTTTCTGATAATTCTGATTATTCATT | p.Lys185IlefsTer4 | p.K185Ifs*4 | O95801 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TTC4 | SNV | Missense_Mutation | novel | c.739N>A | p.Gly247Ser | p.G247S | O95801 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TTC4 | SNV | Missense_Mutation | c.251A>G | p.Asp84Gly | p.D84G | O95801 | protein_coding | deleterious(0.03) | benign(0.081) | TCGA-CK-5914-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TTC4 | SNV | Missense_Mutation | novel | c.745N>T | p.Gly249Cys | p.G249C | O95801 | protein_coding | deleterious(0.04) | benign(0.237) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTC4 | SNV | Missense_Mutation | novel | c.190N>A | p.Leu64Ile | p.L64I | O95801 | protein_coding | tolerated(0.21) | benign(0.059) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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