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Gene: TTC39C |
Gene summary for TTC39C |
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Gene information | Species | Human | Gene symbol | TTC39C | Gene ID | 125488 |
Gene name | tetratricopeptide repeat domain 39C | |
Gene Alias | C18orf17 | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q8N584 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
125488 | TTC39C | LZE24T | Human | Esophagus | ESCC | 6.37e-07 | 2.44e-01 | 0.0596 |
125488 | TTC39C | LZE21T | Human | Esophagus | ESCC | 7.08e-04 | 3.22e-01 | 0.0655 |
125488 | TTC39C | P1T-E | Human | Esophagus | ESCC | 2.61e-17 | 5.92e-01 | 0.0875 |
125488 | TTC39C | P2T-E | Human | Esophagus | ESCC | 6.94e-40 | 6.75e-01 | 0.1177 |
125488 | TTC39C | P4T-E | Human | Esophagus | ESCC | 1.02e-27 | 6.12e-01 | 0.1323 |
125488 | TTC39C | P5T-E | Human | Esophagus | ESCC | 2.69e-33 | 6.27e-01 | 0.1327 |
125488 | TTC39C | P8T-E | Human | Esophagus | ESCC | 2.62e-06 | 1.70e-01 | 0.0889 |
125488 | TTC39C | P9T-E | Human | Esophagus | ESCC | 3.46e-58 | 1.24e+00 | 0.1131 |
125488 | TTC39C | P10T-E | Human | Esophagus | ESCC | 4.63e-19 | 4.58e-01 | 0.116 |
125488 | TTC39C | P11T-E | Human | Esophagus | ESCC | 2.04e-08 | 3.41e-01 | 0.1426 |
125488 | TTC39C | P12T-E | Human | Esophagus | ESCC | 7.29e-38 | 6.95e-01 | 0.1122 |
125488 | TTC39C | P15T-E | Human | Esophagus | ESCC | 8.87e-30 | 6.76e-01 | 0.1149 |
125488 | TTC39C | P16T-E | Human | Esophagus | ESCC | 1.19e-38 | 6.68e-01 | 0.1153 |
125488 | TTC39C | P17T-E | Human | Esophagus | ESCC | 7.72e-14 | 5.87e-01 | 0.1278 |
125488 | TTC39C | P19T-E | Human | Esophagus | ESCC | 8.21e-03 | 3.23e-01 | 0.1662 |
125488 | TTC39C | P20T-E | Human | Esophagus | ESCC | 2.62e-28 | 6.40e-01 | 0.1124 |
125488 | TTC39C | P21T-E | Human | Esophagus | ESCC | 4.40e-60 | 1.08e+00 | 0.1617 |
125488 | TTC39C | P22T-E | Human | Esophagus | ESCC | 5.88e-31 | 5.80e-01 | 0.1236 |
125488 | TTC39C | P23T-E | Human | Esophagus | ESCC | 4.56e-26 | 7.41e-01 | 0.108 |
125488 | TTC39C | P24T-E | Human | Esophagus | ESCC | 4.96e-13 | 3.70e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:00485686 | Oral cavity | NEOLP | embryonic organ development | 71/2005 | 427/18723 | 1.12e-04 | 1.34e-03 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC39C | SNV | Missense_Mutation | c.1079N>A | p.Gly360Asp | p.G360D | Q8N584 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EW-A1J6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
TTC39C | SNV | Missense_Mutation | c.1254N>G | p.Phe418Leu | p.F418L | Q8N584 | protein_coding | tolerated(0.42) | benign(0.023) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
TTC39C | SNV | Missense_Mutation | novel | c.1628N>A | p.Val543Glu | p.V543E | Q8N584 | protein_coding | tolerated(0.2) | benign(0.009) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
TTC39C | SNV | Missense_Mutation | c.1681N>A | p.Asp561Asn | p.D561N | Q8N584 | protein_coding | deleterious(0) | benign(0.125) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TTC39C | SNV | Missense_Mutation | c.1304N>A | p.Arg435Gln | p.R435Q | Q8N584 | protein_coding | tolerated(0.18) | benign(0.014) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TTC39C | SNV | Missense_Mutation | rs762192075 | c.784N>A | p.Glu262Lys | p.E262K | Q8N584 | protein_coding | tolerated(1) | benign(0.045) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TTC39C | SNV | Missense_Mutation | c.1348N>C | p.Ser450Pro | p.S450P | Q8N584 | protein_coding | tolerated(0.11) | benign(0.215) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
TTC39C | SNV | Missense_Mutation | c.1439N>G | p.Asp480Gly | p.D480G | Q8N584 | protein_coding | deleterious(0.01) | benign(0.055) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TTC39C | SNV | Missense_Mutation | c.456N>T | p.Leu152Phe | p.L152F | Q8N584 | protein_coding | deleterious(0.03) | probably_damaging(0.951) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
TTC39C | SNV | Missense_Mutation | rs879697019 | c.748C>T | p.Arg250Cys | p.R250C | Q8N584 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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