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Gene: TTC13 |
Gene summary for TTC13 |
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Gene information | Species | Human | Gene symbol | TTC13 | Gene ID | 79573 |
Gene name | tetratricopeptide repeat domain 13 | |
Gene Alias | TTC13 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q8NBP0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79573 | TTC13 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.06e-19 | -6.36e-01 | 0.0155 |
79573 | TTC13 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.70e-08 | -5.67e-01 | -0.1808 |
79573 | TTC13 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.46e-04 | -7.01e-01 | 0.0216 |
79573 | TTC13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.06e-05 | -5.63e-01 | -0.0811 |
79573 | TTC13 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.51e-06 | -5.79e-01 | -0.1207 |
79573 | TTC13 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.39e-03 | -4.83e-01 | -0.1526 |
79573 | TTC13 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.66e-13 | -4.66e-01 | -0.1464 |
79573 | TTC13 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.54e-13 | -4.73e-01 | -0.1001 |
79573 | TTC13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.23e-04 | -4.28e-01 | -0.059 |
79573 | TTC13 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.70e-02 | -7.01e-01 | -0.00410000000000005 |
79573 | TTC13 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.39e-14 | -6.01e-01 | 0.096 |
79573 | TTC13 | HTA11_9408_2000001011 | Human | Colorectum | AD | 8.06e-03 | -7.01e-01 | 0.0451 |
79573 | TTC13 | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.71e-04 | -6.53e-01 | 0.0528 |
79573 | TTC13 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.18e-11 | -6.48e-01 | 0.0338 |
79573 | TTC13 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.92e-20 | -5.76e-01 | 0.0674 |
79573 | TTC13 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.13e-03 | -6.18e-01 | 0.0112 |
79573 | TTC13 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.92e-07 | -6.20e-01 | 0.0588 |
79573 | TTC13 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.30e-22 | -5.33e-01 | 0.294 |
79573 | TTC13 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.58e-21 | -5.73e-01 | 0.3859 |
79573 | TTC13 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.60e-09 | -6.85e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC13 | SNV | Missense_Mutation | novel | c.1027N>A | p.Ala343Thr | p.A343T | Q8NBP0 | protein_coding | tolerated(0.08) | probably_damaging(0.975) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
TTC13 | SNV | Missense_Mutation | c.1880G>A | p.Arg627Lys | p.R627K | Q8NBP0 | protein_coding | tolerated(0.38) | benign(0.444) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TTC13 | SNV | Missense_Mutation | c.1688G>C | p.Arg563Thr | p.R563T | Q8NBP0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TTC13 | SNV | Missense_Mutation | c.1991N>C | p.Asn664Thr | p.N664T | Q8NBP0 | protein_coding | deleterious(0.02) | possibly_damaging(0.573) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TTC13 | SNV | Missense_Mutation | rs777528572 | c.712G>T | p.Asp238Tyr | p.D238Y | Q8NBP0 | protein_coding | tolerated(0.05) | benign(0.287) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
TTC13 | insertion | Nonsense_Mutation | novel | c.1150_1151insCAGGAAGGGCAGGAAACTGACATTCTGTG | p.Asn384ThrfsTer7 | p.N384Tfs*7 | Q8NBP0 | protein_coding | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
TTC13 | deletion | Frame_Shift_Del | novel | c.435delA | p.Glu146SerfsTer2 | p.E146Sfs*2 | Q8NBP0 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TTC13 | SNV | Missense_Mutation | novel | c.2069T>G | p.Phe690Cys | p.F690C | Q8NBP0 | protein_coding | tolerated(0.07) | possibly_damaging(0.894) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TTC13 | SNV | Missense_Mutation | rs577146647 | c.748C>T | p.Arg250Trp | p.R250W | Q8NBP0 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TTC13 | SNV | Missense_Mutation | rs137956454 | c.2564N>A | p.Arg855His | p.R855H | Q8NBP0 | protein_coding | tolerated_low_confidence(0.68) | benign(0) | TCGA-VS-A9UU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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