Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: TTC1

Gene summary for TTC1

Gene summary.

Gene information	Species	Human
	Gene symbol	TTC1
	Gene ID	7265
	Gene name	tetratricopeptide repeat domain 1
	Gene Alias	TPR1
	Cytomap	5q33.3
	Gene Type	protein-coding
	GO ID	GO:0006457
	UniProtAcc	Q99614

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
7265	TTC1	HTA11_1938_2000001011	Human	Colorectum	AD	3.11e-02	4.16e-01	-0.0811
7265	TTC1	HTA11_347_2000001011	Human	Colorectum	AD	1.71e-13	5.78e-01	-0.1954
7265	TTC1	A002-C-010	Human	Colorectum	FAP	3.82e-02	-1.37e-01	0.242
7265	TTC1	A015-C-203	Human	Colorectum	FAP	2.31e-08	-2.41e-01	-0.1294
7265	TTC1	A002-C-201	Human	Colorectum	FAP	2.86e-04	-2.06e-01	0.0324
7265	TTC1	A001-C-108	Human	Colorectum	FAP	4.78e-03	-1.69e-01	-0.0272
7265	TTC1	A002-C-205	Human	Colorectum	FAP	4.40e-08	-1.98e-01	-0.1236
7265	TTC1	A015-C-006	Human	Colorectum	FAP	3.76e-04	-2.41e-01	-0.0994
7265	TTC1	A015-C-106	Human	Colorectum	FAP	8.34e-06	-1.65e-01	-0.0511
7265	TTC1	A002-C-114	Human	Colorectum	FAP	1.26e-06	-2.62e-01	-0.1561
7265	TTC1	A015-C-104	Human	Colorectum	FAP	3.76e-07	-2.47e-01	-0.1899
7265	TTC1	A001-C-014	Human	Colorectum	FAP	3.32e-05	-1.95e-01	0.0135
7265	TTC1	A002-C-016	Human	Colorectum	FAP	7.98e-13	-2.42e-01	0.0521
7265	TTC1	A015-C-002	Human	Colorectum	FAP	1.31e-04	-2.65e-01	-0.0763
7265	TTC1	A001-C-203	Human	Colorectum	FAP	6.81e-05	-1.23e-01	-0.0481
7265	TTC1	A002-C-116	Human	Colorectum	FAP	5.82e-13	-2.46e-01	-0.0452
7265	TTC1	A014-C-008	Human	Colorectum	FAP	3.30e-04	-2.46e-01	-0.191
7265	TTC1	A018-E-020	Human	Colorectum	FAP	1.28e-06	-1.92e-01	-0.2034
7265	TTC1	F034	Human	Colorectum	FAP	2.99e-07	-1.86e-01	-0.0665
7265	TTC1	F072B	Human	Colorectum	FAP	2.20e-02	-1.50e-01	0.257

Page: 1 2 3 4 5 6 7 8

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:000701510	Cervix	CC	actin filament organization	109/2311	442/18723	4.92e-13	2.45e-10	109
GO:005125810	Cervix	CC	protein polymerization	70/2311	297/18723	5.20e-08	3.11e-06	70
GO:00081549	Cervix	CC	actin polymerization or depolymerization	51/2311	218/18723	4.05e-06	1.05e-04	51
GO:00300419	Cervix	CC	actin filament polymerization	45/2311	191/18723	1.20e-05	2.54e-04	45
GO:0007015	Colorectum	AD	actin filament organization	167/3918	442/18723	1.65e-16	7.94e-14	167
GO:0008154	Colorectum	AD	actin polymerization or depolymerization	90/3918	218/18723	6.14e-12	8.23e-10	90
GO:0030041	Colorectum	AD	actin filament polymerization	81/3918	191/18723	1.35e-11	1.69e-09	81
GO:0051258	Colorectum	AD	protein polymerization	112/3918	297/18723	1.85e-11	2.27e-09	112
GO:0033108	Colorectum	AD	mitochondrial respiratory chain complex assembly	46/3918	93/18723	8.95e-10	6.91e-08	46
GO:0006457	Colorectum	AD	protein folding	73/3918	212/18723	3.24e-06	9.10e-05	73
GO:0000910	Colorectum	AD	cytokinesis	59/3918	173/18723	3.74e-05	6.75e-04	59
GO:0061640	Colorectum	AD	cytoskeleton-dependent cytokinesis	37/3918	100/18723	1.58e-04	2.20e-03	37
GO:0000281	Colorectum	AD	mitotic cytokinesis	25/3918	71/18723	3.77e-03	2.65e-02	25
GO:00070151	Colorectum	SER	actin filament organization	134/2897	442/18723	1.39e-15	5.70e-13	134
GO:00081541	Colorectum	SER	actin polymerization or depolymerization	77/2897	218/18723	3.50e-13	1.19e-10	77
GO:00300411	Colorectum	SER	actin filament polymerization	70/2897	191/18723	5.39e-13	1.65e-10	70
GO:00512581	Colorectum	SER	protein polymerization	91/2897	297/18723	2.72e-11	5.06e-09	91
GO:00070152	Colorectum	MSS	actin filament organization	146/3467	442/18723	1.16e-13	2.67e-11	146
GO:00331082	Colorectum	MSS	mitochondrial respiratory chain complex assembly	44/3467	93/18723	2.17e-10	2.09e-08	44
GO:00081542	Colorectum	MSS	actin polymerization or depolymerization	79/3467	218/18723	4.14e-10	3.49e-08	79

Page: 1 2 3 4 5 6 7 8

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

TTC1

SNV

Missense_Mutation

rs368905325

c.430N>A

p.Glu144Lys

p.E144K

Q99614

protein_coding

tolerated(0.38)

benign(0.006)

TCGA-AN-A046-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

TTC1

SNV

Missense_Mutation

c.852C>A

p.Phe284Leu

p.F284L

Q99614

protein_coding

deleterious(0)

probably_damaging(0.952)

TCGA-AG-A002-01

Colorectum

rectum adenocarcinoma

Male

<65

I/II

Unknown

TTC1

SNV

Missense_Mutation

novel

c.137T>C

p.Leu46Pro

p.L46P

Q99614

protein_coding

tolerated_low_confidence(0.16)

benign(0)

TCGA-A5-A1OF-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

TTC1

SNV

Missense_Mutation

novel

c.824C>A

p.Ser275Tyr

p.S275Y

Q99614

protein_coding

deleterious(0)

possibly_damaging(0.854)

TCGA-A5-A1OF-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

TTC1

SNV

Missense_Mutation

rs535766239

c.464C>T

p.Ser155Leu

p.S155L

Q99614

protein_coding

deleterious(0.03)

possibly_damaging(0.821)

TCGA-AP-A0LM-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

III/IV

Chemotherapy

cisplatin

TTC1

SNV

Missense_Mutation

novel

c.101N>A

p.Pro34His

p.P34H

Q99614

protein_coding

tolerated_low_confidence(0.1)

benign(0.319)

TCGA-AX-A1CE-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unspecific

Paclitaxel

TTC1

SNV

Missense_Mutation

c.658N>A

p.Pro220Thr

p.P220T

Q99614

protein_coding

deleterious(0)

probably_damaging(0.996)

TCGA-AX-A1CE-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unspecific

Paclitaxel

TTC1

SNV

Missense_Mutation

novel

c.569N>T

p.Arg190Met

p.R190M

Q99614

protein_coding

deleterious(0)

probably_damaging(0.994)

TCGA-B5-A1MX-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Hormone Therapy

megace

TTC1

SNV

Missense_Mutation

rs751310634

c.422G>A

p.Arg141Gln

p.R141Q

Q99614

protein_coding

tolerated(0.95)

benign(0.003)

TCGA-B5-A3FA-01

Endometrium

uterine corpus endometrioid carcinoma

Female

>=65

I/II

Unknown

TTC1

SNV

Missense_Mutation

novel

c.324N>T

p.Glu108Asp

p.E108D

Q99614

protein_coding

deleterious(0.05)

benign(0.346)

TCGA-E6-A1LX-01

Endometrium

uterine corpus endometrioid carcinoma

Female

<65

I/II

Unknown

Page: 1 2 3

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1