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Gene: TSR3 |
Gene summary for TSR3 |
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Gene information | Species | Human | Gene symbol | TSR3 | Gene ID | 115939 |
Gene name | TSR3 ribosome maturation factor | |
Gene Alias | C16orf42 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | Q9UJK0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115939 | TSR3 | LZE20T | Human | Esophagus | ESCC | 2.11e-05 | 1.45e-01 | 0.0662 |
115939 | TSR3 | LZE22D1 | Human | Esophagus | HGIN | 2.61e-02 | 1.53e-01 | 0.0595 |
115939 | TSR3 | LZE22T | Human | Esophagus | ESCC | 1.01e-02 | 1.96e-01 | 0.068 |
115939 | TSR3 | LZE24T | Human | Esophagus | ESCC | 3.83e-07 | 1.88e-01 | 0.0596 |
115939 | TSR3 | LZE21T | Human | Esophagus | ESCC | 2.02e-03 | 2.81e-01 | 0.0655 |
115939 | TSR3 | P1T-E | Human | Esophagus | ESCC | 4.88e-15 | 6.79e-01 | 0.0875 |
115939 | TSR3 | P2T-E | Human | Esophagus | ESCC | 1.07e-36 | 7.04e-01 | 0.1177 |
115939 | TSR3 | P4T-E | Human | Esophagus | ESCC | 1.43e-50 | 1.12e+00 | 0.1323 |
115939 | TSR3 | P5T-E | Human | Esophagus | ESCC | 7.20e-42 | 8.29e-01 | 0.1327 |
115939 | TSR3 | P8T-E | Human | Esophagus | ESCC | 3.98e-16 | 2.29e-01 | 0.0889 |
115939 | TSR3 | P9T-E | Human | Esophagus | ESCC | 2.78e-12 | 2.30e-01 | 0.1131 |
115939 | TSR3 | P10T-E | Human | Esophagus | ESCC | 1.59e-23 | 1.07e-01 | 0.116 |
115939 | TSR3 | P11T-E | Human | Esophagus | ESCC | 5.72e-07 | 2.78e-01 | 0.1426 |
115939 | TSR3 | P12T-E | Human | Esophagus | ESCC | 4.92e-21 | 2.85e-01 | 0.1122 |
115939 | TSR3 | P15T-E | Human | Esophagus | ESCC | 2.07e-17 | 2.36e-01 | 0.1149 |
115939 | TSR3 | P16T-E | Human | Esophagus | ESCC | 6.30e-10 | 6.34e-02 | 0.1153 |
115939 | TSR3 | P17T-E | Human | Esophagus | ESCC | 5.56e-07 | 2.89e-01 | 0.1278 |
115939 | TSR3 | P19T-E | Human | Esophagus | ESCC | 1.06e-07 | 5.64e-01 | 0.1662 |
115939 | TSR3 | P20T-E | Human | Esophagus | ESCC | 3.82e-13 | 2.63e-01 | 0.1124 |
115939 | TSR3 | P21T-E | Human | Esophagus | ESCC | 3.30e-27 | 5.23e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:004227427 | Esophagus | HGIN | ribosomal small subunit biogenesis | 27/2587 | 73/18723 | 6.26e-07 | 2.72e-05 | 27 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015221 | Esophagus | ESCC | pseudouridine synthesis | 16/8552 | 18/18723 | 1.78e-04 | 1.15e-03 | 16 |
GO:0000154 | Esophagus | ESCC | rRNA modification | 26/8552 | 37/18723 | 2.16e-03 | 9.62e-03 | 26 |
GO:00311182 | Esophagus | ESCC | rRNA pseudouridine synthesis | 9/8552 | 10/18723 | 5.09e-03 | 1.92e-02 | 9 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSR3 | SNV | Missense_Mutation | c.637G>A | p.Glu213Lys | p.E213K | Q9UJK0 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-AR-A1AI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD | |
TSR3 | SNV | Missense_Mutation | rs754994733 | c.397N>T | p.Pro133Ser | p.P133S | Q9UJK0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TSR3 | SNV | Missense_Mutation | c.393G>T | p.Glu131Asp | p.E131D | Q9UJK0 | protein_coding | tolerated(0.12) | benign(0.246) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TSR3 | SNV | Missense_Mutation | rs149957870 | c.925N>T | p.Arg309Trp | p.R309W | Q9UJK0 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.732) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
TSR3 | SNV | Missense_Mutation | rs771962406 | c.523G>A | p.Val175Ile | p.V175I | Q9UJK0 | protein_coding | tolerated(0.06) | benign(0.166) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSR3 | SNV | Missense_Mutation | novel | c.934G>T | p.Asp312Tyr | p.D312Y | Q9UJK0 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.87) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSR3 | SNV | Missense_Mutation | novel | c.667G>A | p.Ala223Thr | p.A223T | Q9UJK0 | protein_coding | tolerated(0.26) | benign(0.034) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSR3 | SNV | Missense_Mutation | novel | c.735N>G | p.Phe245Leu | p.F245L | Q9UJK0 | protein_coding | deleterious(0.03) | possibly_damaging(0.655) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TSR3 | SNV | Missense_Mutation | rs200565292 | c.557N>A | p.Arg186Gln | p.R186Q | Q9UJK0 | protein_coding | tolerated(0.25) | benign(0.022) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TSR3 | SNV | Missense_Mutation | novel | c.916N>G | p.Ile306Val | p.I306V | Q9UJK0 | protein_coding | tolerated_low_confidence(0.36) | benign(0.013) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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