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Gene: TSPAN18 |
Gene summary for TSPAN18 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TSPAN18 | Gene ID | 90139 |
| Gene name | tetraspanin 18 | |
| Gene Alias | TSPAN | |
| Cytomap | 11p11.2 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96SJ8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 90139 | TSPAN18 | P9T-E | Human | Esophagus | ESCC | 1.44e-05 | 1.80e-01 | 0.1131 |
| 90139 | TSPAN18 | P10T-E | Human | Esophagus | ESCC | 2.55e-28 | 6.26e-01 | 0.116 |
| 90139 | TSPAN18 | P12T-E | Human | Esophagus | ESCC | 8.75e-06 | 1.32e-01 | 0.1122 |
| 90139 | TSPAN18 | P15T-E | Human | Esophagus | ESCC | 3.64e-07 | 1.60e-01 | 0.1149 |
| 90139 | TSPAN18 | P16T-E | Human | Esophagus | ESCC | 1.82e-03 | 4.29e-02 | 0.1153 |
| 90139 | TSPAN18 | P26T-E | Human | Esophagus | ESCC | 3.78e-03 | 7.15e-02 | 0.1276 |
| 90139 | TSPAN18 | P28T-E | Human | Esophagus | ESCC | 8.33e-21 | 4.12e-01 | 0.1149 |
| 90139 | TSPAN18 | P30T-E | Human | Esophagus | ESCC | 1.82e-15 | 5.54e-01 | 0.137 |
| 90139 | TSPAN18 | P31T-E | Human | Esophagus | ESCC | 5.44e-20 | 3.34e-01 | 0.1251 |
| 90139 | TSPAN18 | P42T-E | Human | Esophagus | ESCC | 1.70e-03 | 1.45e-01 | 0.1175 |
| 90139 | TSPAN18 | P49T-E | Human | Esophagus | ESCC | 3.92e-04 | 2.99e-01 | 0.1768 |
| 90139 | TSPAN18 | P52T-E | Human | Esophagus | ESCC | 1.98e-08 | 2.66e-01 | 0.1555 |
| 90139 | TSPAN18 | P56T-E | Human | Esophagus | ESCC | 3.28e-06 | 4.78e-01 | 0.1613 |
| 90139 | TSPAN18 | P107T-E | Human | Esophagus | ESCC | 3.38e-02 | 1.00e-01 | 0.171 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TSPAN18 | deletion | Frame_Shift_Del | c.684_685delGG | p.Val229ThrfsTer25 | p.V229Tfs*25 | Q96SJ8 | protein_coding | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |||
| TSPAN18 | insertion | Frame_Shift_Ins | novel | c.229_230insGTGACCTTCAGCAAGTTGTTGGTTCCCTCTGTATGGAA | p.Val77GlyfsTer29 | p.V77Gfs*29 | Q96SJ8 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
| TSPAN18 | SNV | Missense_Mutation | novel | c.137N>T | p.Ala46Val | p.A46V | Q96SJ8 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TSPAN18 | SNV | Missense_Mutation | rs201625013 | c.388N>A | p.Asp130Asn | p.D130N | Q96SJ8 | protein_coding | tolerated(0.84) | benign(0) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TSPAN18 | SNV | Missense_Mutation | c.54C>A | p.Phe18Leu | p.F18L | Q96SJ8 | protein_coding | tolerated(0.63) | possibly_damaging(0.758) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| TSPAN18 | SNV | Missense_Mutation | rs778653685 | c.518N>T | p.Pro173Leu | p.P173L | Q96SJ8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
| TSPAN18 | SNV | Missense_Mutation | rs148562544 | c.233N>A | p.Arg78His | p.R78H | Q96SJ8 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-CA-6719-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| TSPAN18 | SNV | Missense_Mutation | novel | c.157N>G | p.Thr53Ala | p.T53A | Q96SJ8 | protein_coding | tolerated(0.39) | benign(0.099) | TCGA-G4-6307-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
| TSPAN18 | SNV | Missense_Mutation | novel | c.151N>A | p.Leu51Ile | p.L51I | Q96SJ8 | protein_coding | tolerated(0.23) | probably_damaging(0.927) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| TSPAN18 | SNV | Missense_Mutation | rs377733819 | c.419N>T | p.Ser140Leu | p.S140L | Q96SJ8 | protein_coding | deleterious(0) | possibly_damaging(0.558) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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