|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: TSPAN15 |
Gene summary for TSPAN15 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TSPAN15 | Gene ID | 23555 |
| Gene name | tetraspanin 15 | |
| Gene Alias | 2700063A19Rik | |
| Cytomap | 10q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0006807 | UniProtAcc | O95858 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23555 | TSPAN15 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.12e-08 | 6.27e-01 | -0.0811 |
| 23555 | TSPAN15 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.18e-04 | 4.16e-01 | -0.1088 |
| 23555 | TSPAN15 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.50e-10 | 5.15e-01 | -0.1954 |
| 23555 | TSPAN15 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.26e-05 | 5.96e-01 | -0.1526 |
| 23555 | TSPAN15 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.90e-03 | 3.89e-01 | -0.1464 |
| 23555 | TSPAN15 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.44e-02 | 4.41e-01 | -0.1001 |
| 23555 | TSPAN15 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.91e-09 | 6.13e-01 | -0.059 |
| 23555 | TSPAN15 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.97e-03 | 4.00e-01 | 0.0338 |
| 23555 | TSPAN15 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.61e-02 | 3.51e-01 | 0.0674 |
| 23555 | TSPAN15 | A015-C-203 | Human | Colorectum | FAP | 1.26e-11 | -2.20e-01 | -0.1294 |
| 23555 | TSPAN15 | A001-C-119 | Human | Colorectum | FAP | 6.93e-03 | -2.52e-01 | -0.1557 |
| 23555 | TSPAN15 | A001-C-108 | Human | Colorectum | FAP | 2.71e-05 | -1.99e-01 | -0.0272 |
| 23555 | TSPAN15 | A002-C-205 | Human | Colorectum | FAP | 3.74e-06 | -2.18e-01 | -0.1236 |
| 23555 | TSPAN15 | A015-C-006 | Human | Colorectum | FAP | 5.46e-05 | -2.72e-01 | -0.0994 |
| 23555 | TSPAN15 | A015-C-106 | Human | Colorectum | FAP | 1.45e-04 | -1.75e-01 | -0.0511 |
| 23555 | TSPAN15 | A002-C-114 | Human | Colorectum | FAP | 5.24e-05 | -2.41e-01 | -0.1561 |
| 23555 | TSPAN15 | A015-C-104 | Human | Colorectum | FAP | 7.07e-13 | -2.56e-01 | -0.1899 |
| 23555 | TSPAN15 | A001-C-014 | Human | Colorectum | FAP | 9.32e-06 | -1.61e-01 | 0.0135 |
| 23555 | TSPAN15 | A002-C-016 | Human | Colorectum | FAP | 1.21e-08 | -1.74e-01 | 0.0521 |
| 23555 | TSPAN15 | A015-C-002 | Human | Colorectum | FAP | 2.45e-02 | -2.43e-01 | -0.0763 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
| GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
| GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
| GO:0007219 | Colorectum | AD | Notch signaling pathway | 50/3918 | 172/18723 | 6.92e-03 | 4.26e-02 | 50 |
| GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
| GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
| GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
| GO:00726594 | Colorectum | FAP | protein localization to plasma membrane | 95/2622 | 284/18723 | 4.86e-17 | 9.93e-14 | 95 |
| GO:19907784 | Colorectum | FAP | protein localization to cell periphery | 100/2622 | 333/18723 | 2.19e-14 | 2.68e-11 | 100 |
| GO:00072191 | Colorectum | FAP | Notch signaling pathway | 38/2622 | 172/18723 | 2.56e-03 | 2.01e-02 | 38 |
| GO:00726595 | Colorectum | CRC | protein localization to plasma membrane | 80/2078 | 284/18723 | 1.36e-15 | 4.07e-12 | 80 |
| GO:19907785 | Colorectum | CRC | protein localization to cell periphery | 85/2078 | 333/18723 | 8.75e-14 | 1.05e-10 | 85 |
| GO:00072192 | Colorectum | CRC | Notch signaling pathway | 36/2078 | 172/18723 | 1.26e-04 | 2.42e-03 | 36 |
| GO:0008593 | Colorectum | CRC | regulation of Notch signaling pathway | 21/2078 | 95/18723 | 1.48e-03 | 1.58e-02 | 21 |
| GO:00516044 | Colorectum | CRC | protein maturation | 47/2078 | 294/18723 | 6.52e-03 | 4.70e-02 | 47 |
| GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
| GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
| GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
| GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
| GO:0045746 | Esophagus | ESCC | negative regulation of Notch signaling pathway | 28/8552 | 36/18723 | 8.62e-05 | 6.22e-04 | 28 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TSPAN15 | SNV | Missense_Mutation | c.369N>A | p.Phe123Leu | p.F123L | O95858 | protein_coding | tolerated(1) | benign(0.001) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| TSPAN15 | SNV | Missense_Mutation | novel | c.634N>T | p.Asp212Tyr | p.D212Y | O95858 | protein_coding | deleterious(0.01) | possibly_damaging(0.724) | TCGA-Z7-A8R6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
| TSPAN15 | insertion | In_Frame_Ins | novel | c.220_221insGGGAGTTGCCTGCCAGGCTGCTGGGAGGGTTGGGGTGGCAGC | p.Phe74delinsTrpGluLeuProAlaArgLeuLeuGlyGlyLeuGlyTrpGlnLeu | p.F74delinsWELPARLLGGLGWQL | O95858 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
| TSPAN15 | insertion | Frame_Shift_Ins | novel | c.432_433insTT | p.Met145LeufsTer80 | p.M145Lfs*80 | O95858 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| TSPAN15 | insertion | Nonsense_Mutation | novel | c.434_435insCTCAACTGCATAAGA | p.Met145delinsIleSerThrAlaTerGlu | p.M145delinsISTA*E | O95858 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| TSPAN15 | SNV | Missense_Mutation | c.389N>C | p.Arg130Thr | p.R130T | O95858 | protein_coding | deleterious(0.03) | benign(0.324) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TSPAN15 | SNV | Missense_Mutation | novel | c.83N>T | p.Ser28Phe | p.S28F | O95858 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
| TSPAN15 | SNV | Missense_Mutation | c.704N>T | p.Ala235Val | p.A235V | O95858 | protein_coding | tolerated(0.42) | benign(0.343) | TCGA-AA-3870-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |
| TSPAN15 | SNV | Missense_Mutation | rs772047337 | c.214N>A | p.Val72Ile | p.V72I | O95858 | protein_coding | tolerated(0.73) | benign(0.009) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TSPAN15 | SNV | Missense_Mutation | c.347T>A | p.Phe116Tyr | p.F116Y | O95858 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |