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Gene: TSPAN11 |
Gene summary for TSPAN11 |
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Gene information | Species | Human | Gene symbol | TSPAN11 | Gene ID | 441631 |
Gene name | tetraspanin 11 | |
Gene Alias | VSSW1971 | |
Cytomap | 12p11.21 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | A1L157 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
441631 | TSPAN11 | P11T-E | Human | Esophagus | ESCC | 4.80e-15 | 5.96e-01 | 0.1426 |
441631 | TSPAN11 | P19T-E | Human | Esophagus | ESCC | 1.65e-10 | 8.13e-01 | 0.1662 |
441631 | TSPAN11 | P32T-E | Human | Esophagus | ESCC | 1.96e-05 | 2.40e-01 | 0.1666 |
441631 | TSPAN11 | P61T-E | Human | Esophagus | ESCC | 1.48e-02 | 2.28e-01 | 0.099 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSPAN11 | SNV | Missense_Mutation | rs555750888 | c.329T>C | p.Leu110Pro | p.L110P | A1L157 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSPAN11 | SNV | Missense_Mutation | rs140179345 | c.685G>A | p.Gly229Arg | p.G229R | A1L157 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-BH-A18F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
TSPAN11 | SNV | Missense_Mutation | rs202130566 | c.526N>A | p.Glu176Lys | p.E176K | A1L157 | protein_coding | tolerated(0.48) | benign(0.009) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TSPAN11 | SNV | Missense_Mutation | rs202130566 | c.526N>A | p.Glu176Lys | p.E176K | A1L157 | protein_coding | tolerated(0.48) | benign(0.009) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
TSPAN11 | SNV | Missense_Mutation | rs139552987 | c.175N>A | p.Ala59Thr | p.A59T | A1L157 | protein_coding | tolerated(0.24) | benign(0.013) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
TSPAN11 | insertion | Frame_Shift_Ins | novel | c.45_46insTTATTACCAGGCACAGTAGGCCCTCTCTGCCTGTATCACCACCA | p.Lys17LeufsTer15 | p.K17Lfs*15 | A1L157 | protein_coding | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TSPAN11 | deletion | Frame_Shift_Del | novel | c.523_547delNNNNNNNNNNNNNNNNNNNNNNNNN | p.Glu176AlafsTer123 | p.E176Afs*123 | A1L157 | protein_coding | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
TSPAN11 | SNV | Missense_Mutation | rs750835880 | c.100N>A | p.Val34Ile | p.V34I | A1L157 | protein_coding | deleterious(0.03) | benign(0.127) | TCGA-C5-A7CL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
TSPAN11 | SNV | Missense_Mutation | rs200929072 | c.571N>T | p.Arg191Cys | p.R191C | A1L157 | protein_coding | tolerated(0.2) | possibly_damaging(0.67) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TSPAN11 | SNV | Missense_Mutation | rs371115078 | c.238N>A | p.Gly80Ser | p.G80S | A1L157 | protein_coding | tolerated(0.18) | benign(0.013) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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