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Gene: TSLP |
Gene summary for TSLP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TSLP | Gene ID | 85480 |
| Gene name | thymic stromal lymphopoietin | |
| Gene Alias | TSLP | |
| Cytomap | 5q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q969D9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 85480 | TSLP | LZE4T | Human | Esophagus | ESCC | 3.54e-05 | -2.79e-01 | 0.0811 |
| 85480 | TSLP | LZE7T | Human | Esophagus | ESCC | 4.88e-02 | -3.40e-01 | 0.0667 |
| 85480 | TSLP | LZE20T | Human | Esophagus | ESCC | 4.84e-06 | -2.77e-01 | 0.0662 |
| 85480 | TSLP | LZE6T | Human | Esophagus | ESCC | 8.72e-03 | -3.36e-01 | 0.0845 |
| 85480 | TSLP | P1T-E | Human | Esophagus | ESCC | 1.22e-02 | -3.16e-01 | 0.0875 |
| 85480 | TSLP | P2T-E | Human | Esophagus | ESCC | 1.24e-04 | -3.20e-01 | 0.1177 |
| 85480 | TSLP | P4T-E | Human | Esophagus | ESCC | 2.07e-08 | -2.19e-01 | 0.1323 |
| 85480 | TSLP | P5T-E | Human | Esophagus | ESCC | 4.94e-10 | -3.85e-01 | 0.1327 |
| 85480 | TSLP | P8T-E | Human | Esophagus | ESCC | 6.18e-03 | -2.11e-01 | 0.0889 |
| 85480 | TSLP | P9T-E | Human | Esophagus | ESCC | 2.27e-05 | -4.34e-01 | 0.1131 |
| 85480 | TSLP | P10T-E | Human | Esophagus | ESCC | 6.65e-07 | -2.71e-01 | 0.116 |
| 85480 | TSLP | P11T-E | Human | Esophagus | ESCC | 3.25e-04 | -3.10e-01 | 0.1426 |
| 85480 | TSLP | P12T-E | Human | Esophagus | ESCC | 5.30e-05 | 3.16e-01 | 0.1122 |
| 85480 | TSLP | P15T-E | Human | Esophagus | ESCC | 1.19e-02 | 2.05e-01 | 0.1149 |
| 85480 | TSLP | P16T-E | Human | Esophagus | ESCC | 1.54e-13 | -2.99e-01 | 0.1153 |
| 85480 | TSLP | P20T-E | Human | Esophagus | ESCC | 3.49e-16 | 6.27e-01 | 0.1124 |
| 85480 | TSLP | P22T-E | Human | Esophagus | ESCC | 8.15e-13 | -1.61e-01 | 0.1236 |
| 85480 | TSLP | P27T-E | Human | Esophagus | ESCC | 2.97e-05 | -1.73e-01 | 0.1055 |
| 85480 | TSLP | P31T-E | Human | Esophagus | ESCC | 2.95e-10 | -4.07e-01 | 0.1251 |
| 85480 | TSLP | P32T-E | Human | Esophagus | ESCC | 1.21e-02 | -1.87e-01 | 0.1666 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00607595 | Esophagus | ESCC | regulation of response to cytokine stimulus | 103/8552 | 162/18723 | 3.14e-06 | 3.53e-05 | 103 |
| GO:00019595 | Esophagus | ESCC | regulation of cytokine-mediated signaling pathway | 95/8552 | 150/18723 | 9.48e-06 | 9.04e-05 | 95 |
| GO:00019615 | Esophagus | ESCC | positive regulation of cytokine-mediated signaling pathway | 35/8552 | 50/18723 | 4.33e-04 | 2.44e-03 | 35 |
| GO:00607605 | Esophagus | ESCC | positive regulation of response to cytokine stimulus | 39/8552 | 57/18723 | 4.34e-04 | 2.44e-03 | 39 |
| GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
| GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
| GO:00507303 | Esophagus | ESCC | regulation of peptidyl-tyrosine phosphorylation | 144/8552 | 264/18723 | 2.22e-03 | 9.78e-03 | 144 |
| GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TSLP | SNV | Missense_Mutation | c.412N>A | p.Leu138Met | p.L138M | Q969D9 | protein_coding | deleterious(0.04) | possibly_damaging(0.906) | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TSLP | insertion | Frame_Shift_Ins | novel | c.295_296insT | p.Ala99ValfsTer5 | p.A99Vfs*5 | Q969D9 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
| TSLP | insertion | In_Frame_Ins | novel | c.296_297insCACGTATGTTCCCTTTTGCCTTACTATATGTTCTGT | p.Ala99_Met100insThrTyrValProPheCysLeuThrIleCysSerVal | p.A99_M100insTYVPFCLTICSV | Q969D9 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
| TSLP | SNV | Missense_Mutation | rs765465942 | c.88N>A | p.Asp30Asn | p.D30N | Q969D9 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| TSLP | SNV | Missense_Mutation | novel | c.68N>C | p.Val23Ala | p.V23A | Q969D9 | protein_coding | tolerated(0.09) | benign(0.12) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| TSLP | SNV | Missense_Mutation | rs765465942 | c.88N>A | p.Asp30Asn | p.D30N | Q969D9 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| TSLP | SNV | Missense_Mutation | c.341C>T | p.Ser114Leu | p.S114L | Q969D9 | protein_coding | tolerated(0.14) | benign(0.36) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TSLP | SNV | Missense_Mutation | rs150474294 | c.446N>A | p.Arg149His | p.R149H | Q969D9 | protein_coding | tolerated(0.12) | possibly_damaging(0.784) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TSLP | SNV | Missense_Mutation | rs749099078 | c.445N>T | p.Arg149Cys | p.R149C | Q969D9 | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| TSLP | SNV | Missense_Mutation | novel | c.71G>T | p.Gly24Val | p.G24V | Q969D9 | protein_coding | deleterious(0.03) | probably_damaging(0.936) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 85480 | TSLP | DRUGGABLE GENOME | MEDI9929 |
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