Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TSHR

Gene summary for TSHR

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TSHR

Gene ID

7253

Gene namethyroid stimulating hormone receptor
Gene AliasCHNG1
Cytomap14q31.1
Gene Typeprotein-coding
GO ID

GO:0001659

UniProtAcc

A0A0A0MTJ0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7253TSHRAdj_PTCwithHT_6HumanThyroidHT3.64e-25-9.99e-010.02
7253TSHRAdj_PTCwithHT_8HumanThyroidHT5.93e-03-4.54e-010.0267
7253TSHRPTCwithHT_1HumanThyroidHT2.53e-07-9.04e-010.0238
7253TSHRPTCwithHT_6HumanThyroidHT3.32e-20-9.07e-010.02
7253TSHRPTCwithHT_8HumanThyroidHT1.39e-08-6.41e-010.0351
7253TSHRPTCwithoutHT_2HumanThyroidPTC7.21e-05-4.80e-010.0419
7253TSHRPTCwithoutHT_7HumanThyroidPTC6.98e-03-5.77e-010.0381
7253TSHRmale-WTAHumanThyroidPTC4.03e-608.32e-020.1037
7253TSHRPTC01HumanThyroidPTC5.07e-189.11e-010.1899
7253TSHRPTC03HumanThyroidPTC6.20e-039.62e-010.1784
7253TSHRPTC04HumanThyroidPTC4.90e-076.80e-010.1927
7253TSHRPTC05HumanThyroidPTC1.92e-131.41e+000.2065
7253TSHRPTC06HumanThyroidPTC1.67e-411.72e+000.2057
7253TSHRPTC07HumanThyroidPTC1.16e-531.65e+000.2044
7253TSHRATC08HumanThyroidATC7.40e-19-6.06e-010.0541
7253TSHRATC09HumanThyroidATC6.12e-12-9.82e-010.2871
7253TSHRATC11HumanThyroidATC4.89e-02-1.01e+000.3386
7253TSHRATC12HumanThyroidATC1.89e-29-1.01e+000.34
7253TSHRATC13HumanThyroidATC2.36e-29-1.01e+000.34
7253TSHRATC1HumanThyroidATC2.96e-09-9.94e-010.2878
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190165324ThyroidHTcellular response to peptide46/1272359/187232.46e-055.48e-0446
GO:004343427ThyroidHTresponse to peptide hormone49/1272414/187231.05e-041.75e-0349
GO:19908455ThyroidHTadaptive thermogenesis22/1272157/187239.54e-049.83e-0322
GO:00016595ThyroidHTtemperature homeostasis23/1272174/187231.64e-031.50e-0223
GO:01061067ThyroidHTcold-induced thermogenesis20/1272144/187231.77e-031.59e-0220
GO:01201617ThyroidHTregulation of cold-induced thermogenesis20/1272144/187231.77e-031.59e-0220
GO:007137519ThyroidHTcellular response to peptide hormone stimulus33/1272290/187232.53e-032.12e-0233
GO:1901653111ThyroidPTCcellular response to peptide169/5968359/187239.81e-102.89e-08169
GO:0043434113ThyroidPTCresponse to peptide hormone188/5968414/187234.13e-091.09e-07188
GO:0071375110ThyroidPTCcellular response to peptide hormone stimulus136/5968290/187235.49e-081.17e-06136
GO:000975519ThyroidPTChormone-mediated signaling pathway80/5968190/187231.84e-039.91e-0380
GO:010610613ThyroidPTCcold-induced thermogenesis61/5968144/187235.08e-032.35e-0261
GO:012016113ThyroidPTCregulation of cold-induced thermogenesis61/5968144/187235.08e-032.35e-0261
GO:199084513ThyroidPTCadaptive thermogenesis64/5968157/187231.14e-024.50e-0264
GO:190165325ThyroidATCcellular response to peptide173/6293359/187235.87e-091.28e-07173
GO:004343428ThyroidATCresponse to peptide hormone192/6293414/187233.63e-086.70e-07192
GO:007137524ThyroidATCcellular response to peptide hormone stimulus138/6293290/187234.90e-077.05e-06138
GO:010610621ThyroidATCcold-induced thermogenesis68/6293144/187234.70e-042.76e-0368
GO:012016121ThyroidATCregulation of cold-induced thermogenesis68/6293144/187234.70e-042.76e-0368
GO:199084521ThyroidATCadaptive thermogenesis71/6293157/187231.59e-037.99e-0371
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TSHRSNVMissense_Mutationrs747590314c.739N>Ap.Glu247Lysp.E247Kprotein_codingtolerated(0.07)benign(0.351)TCGA-A2-A0YK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
TSHRSNVMissense_Mutationc.1960A>Gp.Ile654Valp.I654Vprotein_codingdeleterious(0)probably_damaging(0.995)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TSHRSNVMissense_Mutationnovelc.1143T>Ap.Phe381Leup.F381Lprotein_codingdeleterious(0.04)possibly_damaging(0.861)TCGA-BH-A0AY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapySD
TSHRSNVMissense_Mutationc.782N>Tp.Lys261Metp.K261Mprotein_codingdeleterious(0)probably_damaging(0.931)TCGA-BH-A18V-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TSHRSNVMissense_Mutationc.1370N>Ap.Ala457Aspp.A457Dprotein_codingdeleterious(0)probably_damaging(0.999)TCGA-C8-A12O-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TSHRSNVMissense_Mutationnovelc.933G>Cp.Gln311Hisp.Q311Hprotein_codingtolerated(0.22)benign(0.009)TCGA-OL-A5RX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TSHRinsertionFrame_Shift_Insnovelc.152_153insTTTCGGAGGATGGAGAAATAp.Pro52PhefsTer13p.P52Ffs*13protein_codingTCGA-A8-A08C-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapy5-fluorouracilCR
TSHRdeletionFrame_Shift_Delnovelc.595delNp.Thr200GlnfsTer8p.T200Qfs*8protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
TSHRSNVMissense_Mutationnovelc.2206N>Ap.Glu736Lysp.E736Kprotein_codingtolerated(0.08)benign(0)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
TSHRSNVMissense_Mutationrs368452281c.2120N>Ap.Arg707Glnp.R707Qprotein_codingdeleterious(0.03)benign(0.091)TCGA-C5-A1MH-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACESIBUTRAMINE HYDROCHLORIDESIBUTRAMINE HYDROCHLORIDE
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE(S)-FLUOXETINECHEMBL1169388
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACEBERGAMOTTINBERGAMOTTIN
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACETHYROTROPIN ALFA
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACEDECANOIC ACIDDECANOIC ACID
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACE(S)-VERAPAMIL(S)-VERAPAMIL
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACEGNF-PF-2893CHEMBL312032
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACESB-222200SB-222200
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACEDEXPROPRANOLOLDEXPROPRANOLOL
7253TSHRCLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME, CELL SURFACECLOTRIMAZOLECLOTRIMAZOLE
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