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Gene: TSEN2 |
Gene summary for TSEN2 |
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Gene information | Species | Human | Gene symbol | TSEN2 | Gene ID | 80746 |
Gene name | tRNA splicing endonuclease subunit 2 | |
Gene Alias | PCH2B | |
Cytomap | 3p25.2 | |
Gene Type | protein-coding | GO ID | GO:0000379 | UniProtAcc | A0A024R2H2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80746 | TSEN2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.18e-10 | -4.07e-01 | 0.0155 |
80746 | TSEN2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.72e-05 | -4.21e-01 | -0.1808 |
80746 | TSEN2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.49e-03 | -3.11e-01 | -0.1207 |
80746 | TSEN2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.37e-04 | -3.16e-01 | -0.1464 |
80746 | TSEN2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.14e-08 | -4.21e-01 | 0.096 |
80746 | TSEN2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.87e-05 | -3.59e-01 | 0.0674 |
80746 | TSEN2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.03e-04 | -3.30e-01 | 0.294 |
80746 | TSEN2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.08e-14 | -4.60e-01 | 0.3005 |
80746 | TSEN2 | A002-C-010 | Human | Colorectum | FAP | 1.15e-06 | 2.28e-01 | 0.242 |
80746 | TSEN2 | A015-C-203 | Human | Colorectum | FAP | 3.23e-24 | -4.64e-01 | -0.1294 |
80746 | TSEN2 | A015-C-204 | Human | Colorectum | FAP | 6.31e-04 | -2.08e-01 | -0.0228 |
80746 | TSEN2 | A014-C-040 | Human | Colorectum | FAP | 3.95e-04 | -4.27e-01 | -0.1184 |
80746 | TSEN2 | A002-C-201 | Human | Colorectum | FAP | 2.22e-11 | -2.28e-01 | 0.0324 |
80746 | TSEN2 | A002-C-203 | Human | Colorectum | FAP | 2.30e-04 | 3.09e-02 | 0.2786 |
80746 | TSEN2 | A001-C-119 | Human | Colorectum | FAP | 5.05e-08 | -3.43e-01 | -0.1557 |
80746 | TSEN2 | A001-C-108 | Human | Colorectum | FAP | 9.51e-11 | -7.78e-02 | -0.0272 |
80746 | TSEN2 | A002-C-205 | Human | Colorectum | FAP | 1.34e-16 | -2.13e-01 | -0.1236 |
80746 | TSEN2 | A015-C-005 | Human | Colorectum | FAP | 5.65e-04 | -2.61e-01 | -0.0336 |
80746 | TSEN2 | A015-C-006 | Human | Colorectum | FAP | 1.49e-12 | -3.58e-01 | -0.0994 |
80746 | TSEN2 | A015-C-106 | Human | Colorectum | FAP | 5.54e-09 | -1.54e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00083804 | Colorectum | FAP | RNA splicing | 108/2622 | 434/18723 | 7.90e-10 | 1.86e-07 | 108 |
GO:00083805 | Colorectum | CRC | RNA splicing | 90/2078 | 434/18723 | 2.80e-09 | 7.97e-07 | 90 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSEN2 | SNV | Missense_Mutation | c.109N>C | p.Phe37Leu | p.F37L | Q8NCE0 | protein_coding | tolerated(0.08) | benign(0.247) | TCGA-C8-A134-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
TSEN2 | SNV | Missense_Mutation | c.955N>C | p.Glu319Gln | p.E319Q | Q8NCE0 | protein_coding | tolerated(0.17) | benign(0.086) | TCGA-D8-A13Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TSEN2 | SNV | Missense_Mutation | c.182N>G | p.Tyr61Cys | p.Y61C | Q8NCE0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-E9-A1RG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
TSEN2 | insertion | Nonsense_Mutation | novel | c.919_920insCTTATTAAATATTTAGCTAAGAAAGCATTATTA | p.Leu307delinsSerTyrTerIlePheSerTerGluSerIleIleMet | p.L307delinsSY*IFS*ESIIM | Q8NCE0 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
TSEN2 | insertion | In_Frame_Ins | novel | c.534_542dupAAAGTCAGG | p.Lys179_Gly181dup | p.K179_G181dup | Q8NCE0 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
TSEN2 | insertion | Nonsense_Mutation | novel | c.1268_1269insAGGGTGGCAGGAGCAAGAATGAGAGGATGAGTGAA | p.Ile424GlyfsTer7 | p.I424Gfs*7 | Q8NCE0 | protein_coding | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
TSEN2 | deletion | Frame_Shift_Del | novel | c.1278_1300delNNNNNNNNNNNNNNNNNNNNNNN | p.Ser427GlyfsTer10 | p.S427Gfs*10 | Q8NCE0 | protein_coding | TCGA-E2-A1LE-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | herceptin | PD | ||
TSEN2 | SNV | Missense_Mutation | c.466N>A | p.Gly156Arg | p.G156R | Q8NCE0 | protein_coding | tolerated(0.37) | benign(0.157) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSEN2 | SNV | Missense_Mutation | rs750726691 | c.467N>A | p.Gly156Glu | p.G156E | Q8NCE0 | protein_coding | tolerated(1) | benign(0.001) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TSEN2 | SNV | Missense_Mutation | c.628N>T | p.Val210Leu | p.V210L | Q8NCE0 | protein_coding | tolerated(0.55) | benign(0.003) | TCGA-A6-6651-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Ancillary | leucovorin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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