Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TRPV2

Gene summary for TRPV2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TRPV2

Gene ID

51393

Gene nametransient receptor potential cation channel subfamily V member 2
Gene AliasVRL
Cytomap17p11.2
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q9Y5S1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51393TRPV2ATC2HumanThyroidATC1.28e-231.19e+000.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001604927ThyroidATCcell growth241/6293482/187234.27e-142.35e-12241
GO:003134623ThyroidATCpositive regulation of cell projection organization186/6293353/187237.99e-144.23e-12186
GO:003253526ThyroidATCregulation of cellular component size191/6293383/187232.51e-118.69e-10191
GO:000155826ThyroidATCregulation of cell growth201/6293414/187231.57e-104.76e-09201
GO:001097523ThyroidATCregulation of neuron projection development212/6293445/187234.16e-101.14e-08212
GO:006156423ThyroidATCaxon development220/6293467/187236.85e-101.80e-08220
GO:000740919ThyroidATCaxonogenesis197/6293418/187235.09e-091.13e-07197
GO:001072022ThyroidATCpositive regulation of cell development146/6293298/187232.36e-084.56e-07146
GO:004867522ThyroidATCaxon extension68/6293120/187231.73e-072.75e-0668
GO:005076922ThyroidATCpositive regulation of neurogenesis112/6293225/187233.53e-075.21e-06112
GO:005076723ThyroidATCregulation of neurogenesis168/6293364/187233.73e-075.48e-06168
GO:004577314ThyroidATCpositive regulation of axon extension30/629342/187236.06e-078.44e-0630
GO:199013824ThyroidATCneuron projection extension89/6293172/187236.63e-079.13e-0689
GO:005077213ThyroidATCpositive regulation of axonogenesis48/629379/187236.89e-079.35e-0648
GO:004858823ThyroidATCdevelopmental cell growth114/6293234/187231.11e-061.44e-05114
GO:006056019ThyroidATCdevelopmental growth involved in morphogenesis114/6293234/187231.11e-061.44e-05114
GO:005077011ThyroidATCregulation of axonogenesis80/6293154/187231.95e-062.34e-0580
GO:005196014ThyroidATCregulation of nervous system development195/6293443/187232.62e-063.06e-05195
GO:000940832ThyroidATCresponse to heat60/6293110/187234.89e-065.32e-0560
GO:005196221ThyroidATCpositive regulation of nervous system development126/6293272/187238.17e-068.27e-05126
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TRPV2SNVMissense_Mutationnovelc.355N>Cp.Cys119Argp.C119RQ9Y5S1protein_codingdeleterious(0)probably_damaging(0.964)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TRPV2SNVMissense_Mutationc.833N>Ap.Ala278Aspp.A278DQ9Y5S1protein_codingdeleterious(0.03)benign(0.101)TCGA-AN-A0AL-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
TRPV2SNVMissense_Mutationc.947N>Ap.Arg316Glnp.R316QQ9Y5S1protein_codingdeleterious(0)probably_damaging(0.995)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TRPV2SNVMissense_Mutationnovelc.1322N>Gp.Leu441Argp.L441RQ9Y5S1protein_codingdeleterious(0.01)possibly_damaging(0.786)TCGA-E2-A1B0-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
TRPV2SNVMissense_Mutationc.670N>Ap.Val224Metp.V224MQ9Y5S1protein_codingtolerated(0.17)benign(0.219)TCGA-E9-A243-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilPD
TRPV2insertionFrame_Shift_Insnovelc.1495_1496insAp.Leu499HisfsTer157p.L499Hfs*157Q9Y5S1protein_codingTCGA-AO-A0JM-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
TRPV2insertionFrame_Shift_Insnovelc.1497_1498insATAATTATATATAp.Val500IlefsTer160p.V500Ifs*160Q9Y5S1protein_codingTCGA-AO-A0JM-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
TRPV2insertionIn_Frame_Insnovelc.2032_2033insTAACCGGATGTTGGAGCCAGATTCGAATCCp.Cys678delinsLeuThrGlyCysTrpSerGlnIleArgIleArgp.C678delinsLTGCWSQIRIRQ9Y5S1protein_codingTCGA-BH-A0AY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapySD
TRPV2insertionFrame_Shift_Insnovelc.1218_1219insCTCAGCCTCCCAAGTAp.Ala407LeufsTer70p.A407Lfs*70Q9Y5S1protein_codingTCGA-BH-A0BD-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
TRPV2SNVMissense_Mutationc.1375N>Ap.Val459Metp.V459MQ9Y5S1protein_codingtolerated(0.2)benign(0.205)TCGA-EA-A3QD-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
51393TRPV2DRUGGABLE GENOME, ION CHANNEL, CELL SURFACEblocker135652740
51393TRPV2DRUGGABLE GENOME, ION CHANNEL, CELL SURFACEactivator178100971CANNABIDIOL
51393TRPV2DRUGGABLE GENOME, ION CHANNEL, CELL SURFACEblocker135652746
51393TRPV2DRUGGABLE GENOME, ION CHANNEL, CELL SURFACEblocker135649936AMILORIDE
51393TRPV2DRUGGABLE GENOME, ION CHANNEL, CELL SURFACEblocker135651058
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