![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TROVE2 |
Gene summary for TROVE2 |
![]() |
Gene information | Species | Human | Gene symbol | TROVE2 | Gene ID | 6738 |
Gene name | Ro60, Y RNA binding protein | |
Gene Alias | RORNP | |
Cytomap | 1q31.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P10155 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6738 | TROVE2 | P1T-E | Human | Esophagus | ESCC | 9.69e-09 | 6.90e-01 | 0.0875 |
6738 | TROVE2 | P2T-E | Human | Esophagus | ESCC | 1.96e-58 | 1.05e+00 | 0.1177 |
6738 | TROVE2 | P4T-E | Human | Esophagus | ESCC | 3.78e-31 | 8.63e-01 | 0.1323 |
6738 | TROVE2 | P5T-E | Human | Esophagus | ESCC | 1.32e-35 | 6.87e-01 | 0.1327 |
6738 | TROVE2 | P8T-E | Human | Esophagus | ESCC | 1.78e-23 | 5.43e-01 | 0.0889 |
6738 | TROVE2 | P9T-E | Human | Esophagus | ESCC | 1.87e-19 | 5.72e-01 | 0.1131 |
6738 | TROVE2 | P10T-E | Human | Esophagus | ESCC | 5.25e-50 | 1.02e+00 | 0.116 |
6738 | TROVE2 | P11T-E | Human | Esophagus | ESCC | 2.55e-20 | 9.35e-01 | 0.1426 |
6738 | TROVE2 | P12T-E | Human | Esophagus | ESCC | 4.24e-37 | 7.51e-01 | 0.1122 |
6738 | TROVE2 | P15T-E | Human | Esophagus | ESCC | 3.56e-31 | 6.96e-01 | 0.1149 |
6738 | TROVE2 | P16T-E | Human | Esophagus | ESCC | 1.15e-65 | 1.28e+00 | 0.1153 |
6738 | TROVE2 | P17T-E | Human | Esophagus | ESCC | 2.86e-05 | 5.43e-01 | 0.1278 |
6738 | TROVE2 | P19T-E | Human | Esophagus | ESCC | 1.68e-10 | 9.82e-01 | 0.1662 |
6738 | TROVE2 | P20T-E | Human | Esophagus | ESCC | 4.84e-29 | 7.83e-01 | 0.1124 |
6738 | TROVE2 | P21T-E | Human | Esophagus | ESCC | 1.16e-40 | 8.60e-01 | 0.1617 |
6738 | TROVE2 | P22T-E | Human | Esophagus | ESCC | 2.65e-40 | 8.58e-01 | 0.1236 |
6738 | TROVE2 | P23T-E | Human | Esophagus | ESCC | 2.97e-35 | 8.76e-01 | 0.108 |
6738 | TROVE2 | P24T-E | Human | Esophagus | ESCC | 1.94e-21 | 5.67e-01 | 0.1287 |
6738 | TROVE2 | P26T-E | Human | Esophagus | ESCC | 5.34e-47 | 9.59e-01 | 0.1276 |
6738 | TROVE2 | P27T-E | Human | Esophagus | ESCC | 8.60e-28 | 6.00e-01 | 0.1055 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TROVE2 | SNV | Missense_Mutation | novel | c.1503N>A | p.Met501Ile | p.M501I | P10155 | protein_coding | deleterious(0.01) | benign(0.393) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TROVE2 | SNV | Missense_Mutation | novel | c.1048T>G | p.Leu350Val | p.L350V | P10155 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TROVE2 | SNV | Missense_Mutation | novel | c.1325N>T | p.Ala442Val | p.A442V | P10155 | protein_coding | tolerated(0.66) | benign(0.003) | TCGA-AO-A0JE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
TROVE2 | SNV | Missense_Mutation | c.445N>T | p.Arg149Trp | p.R149W | P10155 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1F2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TROVE2 | SNV | Missense_Mutation | novel | c.661N>C | p.Glu221Gln | p.E221Q | P10155 | protein_coding | deleterious(0.01) | possibly_damaging(0.861) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
TROVE2 | SNV | Missense_Mutation | c.868N>T | p.Ala290Ser | p.A290S | P10155 | protein_coding | tolerated(0.65) | benign(0.151) | TCGA-E2-A155-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
TROVE2 | insertion | Nonsense_Mutation | novel | c.466_467insG | p.Tyr156Ter | p.Y156* | P10155 | protein_coding | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
TROVE2 | insertion | Nonsense_Mutation | novel | c.467_468insGCCTATGCTCTTTGCACTTGCCATTTGTTCC | p.Tyr156Ter | p.Y156* | P10155 | protein_coding | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
TROVE2 | deletion | Frame_Shift_Del | novel | c.1463delA | p.Lys488ArgfsTer9 | p.K488Rfs*9 | P10155 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TROVE2 | SNV | Missense_Mutation | novel | c.332C>T | p.Ala111Val | p.A111V | P10155 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |