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Gene: TRMT9B |
Gene summary for TRMT9B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TRMT9B | Gene ID | 57604 |
| Gene name | tRNA methyltransferase 9B (putative) | |
| Gene Alias | C8orf79 | |
| Cytomap | 8p22 | |
| Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q9P272 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57604 | TRMT9B | AEH-subject1 | Human | Endometrium | AEH | 8.23e-05 | 1.41e-01 | -0.3059 |
| 57604 | TRMT9B | AEH-subject2 | Human | Endometrium | AEH | 1.39e-04 | 1.79e-01 | -0.2525 |
| 57604 | TRMT9B | AEH-subject3 | Human | Endometrium | AEH | 1.88e-08 | 2.58e-01 | -0.2576 |
| 57604 | TRMT9B | AEH-subject4 | Human | Endometrium | AEH | 2.39e-08 | 2.66e-01 | -0.2657 |
| 57604 | TRMT9B | AEH-subject5 | Human | Endometrium | AEH | 1.66e-03 | 1.30e-01 | -0.2953 |
| 57604 | TRMT9B | EEC-subject1 | Human | Endometrium | EEC | 7.12e-13 | 3.70e-01 | -0.2682 |
| 57604 | TRMT9B | EEC-subject4 | Human | Endometrium | EEC | 2.24e-16 | 3.81e-01 | -0.2571 |
| 57604 | TRMT9B | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.66e-03 | 1.73e-01 | -0.1934 |
| 57604 | TRMT9B | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.87e-05 | 1.23e-01 | -0.1269 |
| 57604 | TRMT9B | male-WTA | Human | Thyroid | PTC | 4.70e-13 | 1.94e-01 | 0.1037 |
| 57604 | TRMT9B | PTC01 | Human | Thyroid | PTC | 5.96e-08 | 2.05e-01 | 0.1899 |
| 57604 | TRMT9B | PTC03 | Human | Thyroid | PTC | 5.87e-19 | 8.14e-01 | 0.1784 |
| 57604 | TRMT9B | PTC04 | Human | Thyroid | PTC | 4.20e-46 | 7.21e-01 | 0.1927 |
| 57604 | TRMT9B | PTC05 | Human | Thyroid | PTC | 2.87e-07 | 2.90e-01 | 0.2065 |
| 57604 | TRMT9B | PTC06 | Human | Thyroid | PTC | 3.97e-14 | 3.74e-01 | 0.2057 |
| 57604 | TRMT9B | PTC07 | Human | Thyroid | PTC | 2.53e-27 | 4.68e-01 | 0.2044 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00344707 | Endometrium | AEH | ncRNA processing | 62/2100 | 395/18723 | 3.93e-03 | 2.65e-02 | 62 |
| GO:003447012 | Endometrium | EEC | ncRNA processing | 63/2168 | 395/18723 | 5.20e-03 | 3.26e-02 | 63 |
| GO:003447018 | Thyroid | PTC | ncRNA processing | 215/5968 | 395/18723 | 7.14e-21 | 1.22e-18 | 215 |
| GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
| GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
| GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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